A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer's Disease.

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  • Additional Information
    • Affiliation:
      NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada
      Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal, QC, Canada
      Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada
      Groupe de Recherche sur le Système Nerveux Central (GRSNC), Université de Montréal, Montreal, QC, Canada
      Centre interdisciplinaire de recherche sur le cerveau et l'apprentissage (CIRCA), Université de Montréal, Montreal, QC, Canada
      Department of Biomedical Sciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada
      Montreal Heart Institute, Montreal, QC, Canada
      PERFORM Centre, Concordia University, Montreal, QC, Canada
      Department of Psychology, Faculty of Arts and Sciences, Université de Montréal, Montreal, QC, Canada
      Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada
      Institut de Recherches Cliniques de Montréal, Université de Montréal, Montreal, QC, Canada
      Physics Department, Concordia University, Montreal, QC, Canada
      Functional Neuroimaging Unit, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Université de Montréal, Montreal, QC, Canada
      Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada
    • Abstract:
      Background: Vascular risk factors such as arterial stiffness play an important role in the etiology of Alzheimer's disease (AD), presumably due to the emergence of white matter lesions. However, the impact of arterial stiffness to white matter structure involved in the etiology of AD, including the corpus callosum remains poorly understood.Objective: The aims of the study are to better understand the relationship between arterial stiffness, white matter microstructure, and perfusion of the corpus callosum in older adults.Methods: Arterial stiffness was estimated using the gold standard measure of carotid-femoral pulse wave velocity (cfPWV). Cognitive performance was evaluated with the Trail Making Test part B-A. Neurite orientation dispersion and density imaging was used to obtain microstructural information such as neurite density and extracellular water diffusion. The cerebral blood flow was estimated using arterial spin labelling.Results: cfPWV better predicts the microstructural integrity of the corpus callosum when compared with other index of vascular aging (the augmentation index, the systolic blood pressure, and the pulse pressure). In particular, significant associations were found between the cfPWV, an alteration of the extracellular water diffusion, and a neuronal density increase in the body of the corpus callosum which was also correlated with the performance in cognitive flexibility.Conclusion: Our results suggest that arterial stiffness is associated with an alteration of brain integrity which impacts cognitive function in older adults.
    • Journal Subset:
      Biomedical; Blind Peer Reviewed; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed
    • ISSN:
      1387-2877
    • MEDLINE Info:
      PMID: NLM32741837 NLM UID: 9814863
    • Publication Date:
      In Process
    • Publication Date:
      20200927
    • DOI:
      10.3233/JAD-200668
    • Accession Number:
      145990560
  • Citations
    • ABNT:
      BADJI, A. et al. A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease. Journal of Alzheimer’s Disease, [s. l.], v. 77, n. 2, p. 591–605, 2020. DOI 10.3233/JAD-200668. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=145990560. Acesso em: 24 nov. 2020.
    • AMA:
      Badji A, de la Colina AN, Boshkovski T, et al. A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease. Journal of Alzheimer’s Disease. 2020;77(2):591-605. doi:10.3233/JAD-200668
    • APA:
      Badji, A., de la Colina, A. N., Boshkovski, T., Sabra, D., Karakuzu, A., Robitaille-Grou, M.-C., Gros, C., Joubert, S., Bherer, L., Lamarre-cliche, M., Stikov, N., Gauthier, C. J., Cohen-Adad, J., & Girouard, H. (2020). A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease. Journal of Alzheimer’s Disease, 77(2), 591–605. https://doi.org/10.3233/JAD-200668
    • Chicago/Turabian: Author-Date:
      Badji, Atef, Adrián Noriega de la Colina, Tommy Boshkovski, Dalia Sabra, Agah Karakuzu, Marie-Christine Robitaille-Grou, Charley Gros, et al. 2020. “A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease.” Journal of Alzheimer’s Disease 77 (2): 591–605. doi:10.3233/JAD-200668.
    • Harvard:
      Badji, A. et al. (2020) ‘A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease’, Journal of Alzheimer’s Disease, 77(2), pp. 591–605. doi: 10.3233/JAD-200668.
    • Harvard: Australian:
      Badji, A, de la Colina, AN, Boshkovski, T, Sabra, D, Karakuzu, A, Robitaille-Grou, M-C, Gros, C, Joubert, S, Bherer, L, Lamarre-cliche, M, Stikov, N, Gauthier, CJ, Cohen-Adad, J & Girouard, H 2020, ‘A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease’, Journal of Alzheimer’s Disease, vol. 77, no. 2, pp. 591–605, viewed 24 November 2020, .
    • MLA:
      Badji, Atef, et al. “A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease.” Journal of Alzheimer’s Disease, vol. 77, no. 2, Sept. 2020, pp. 591–605. EBSCOhost, doi:10.3233/JAD-200668.
    • Chicago/Turabian: Humanities:
      Badji, Atef, Adrián Noriega de la Colina, Tommy Boshkovski, Dalia Sabra, Agah Karakuzu, Marie-Christine Robitaille-Grou, Charley Gros, et al. “A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease.” Journal of Alzheimer’s Disease 77, no. 2 (September 15, 2020): 591–605. doi:10.3233/JAD-200668.
    • Vancouver/ICMJE:
      Badji A, de la Colina AN, Boshkovski T, Sabra D, Karakuzu A, Robitaille-Grou M-C, et al. A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer’s Disease. Journal of Alzheimer’s Disease [Internet]. 2020 Sep 15 [cited 2020 Nov 24];77(2):591–605. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=145990560