Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes.

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  • Additional Information
    • Affiliation:
      Risk Analysis Research Center, Sookmyung Women's University, Seoul 04310, Republic of Korea
      Food Standard Research Center, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea
      Department of Food & Nutrition, Dong-eui University, Busan 47340, Republic of Korea
      Department of Food and Nutrition, Sookmyung Women's University, Seoul 04310, Republic of Korea
      Department of Oral Microbiology, College of Dentistry, Wonkwang University, Iksan, Jeollabuk-do 54538, Republic of Korea
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      This study investigated if intestinal Clostridioides difficile (CD) causes liver injury. Four-week-old male C3H/HeN mice were treated with phosphate-buffered solution (control), CD, diethylnitrosamine (DEN) to induce liver injury with PBS (DEN+PBS), and DEN with CD (DEN+CD) for nine weeks. After sacrifice, livers and mesenteric lymph nodes (MLNs) were removed and bacterial translocation, transcriptomes, and proteins were analysed. CD was found in 20% of MLNs from the control and DEN+PBS groups, in 30% of MLNs from the CD group, and in 75% of MLNs from the DEN+CD groups, which had injured livers. Also, CD was detected in 50% of the livers in the DEN+CD group with CD-positive MLNs. Elevated IL-1β, HB-EGF, EGFR, TGF-α, PCNA, DES, HMGB1, and CRP expressions were observed in the CD and DEN+CD groups as compared to the control and DEN+PBS groups. Protein levels of IL-6 and HMGB1 were higher in the CD and DEN+CD groups than in the control and DEN+PBS groups. These results indicate that intestinal CD can initiate and aggravate liver injury, and the mechanism of pathogenesis for liver injury should be investigated in further studies.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200918
    • Publication Date:
      20200918
    • DOI:
      10.1155/2020/7929610
    • Accession Number:
      145717738
  • Citations
    • ABNT:
      LEE, S. et al. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International, [s. l.], p. 1–11, 2020. DOI 10.1155/2020/7929610. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=145717738. Acesso em: 1 dez. 2020.
    • AMA:
      Lee S, Lee H, Kim S, et al. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International. September 2020:1-11. doi:10.1155/2020/7929610
    • APA:
      Lee, S., Lee, H., Kim, S., Lee, J., Ha, J., Choi, Y., Oh, H., Kim, Y., Lee, Y., Choi, K.-H., & Yoon, Y. (2020). Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International, 1–11. https://doi.org/10.1155/2020/7929610
    • Chicago/Turabian: Author-Date:
      Lee, Soomin, Heeyoung Lee, Sejeong Kim, Jeeyeon Lee, Jimyeong Ha, Yukyung Choi, Hyemin Oh, et al. 2020. “Intestinal Clostridioides Difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes.” BioMed Research International, September, 1–11. doi:10.1155/2020/7929610.
    • Harvard:
      Lee, S. et al. (2020) ‘Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes’, BioMed Research International, pp. 1–11. doi: 10.1155/2020/7929610.
    • Harvard: Australian:
      Lee, S, Lee, H, Kim, S, Lee, J, Ha, J, Choi, Y, Oh, H, Kim, Y, Lee, Y, Choi, K-H & Yoon, Y 2020, ‘Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes’, BioMed Research International, pp. 1–11, viewed 1 December 2020, .
    • MLA:
      Lee, Soomin, et al. “Intestinal Clostridioides Difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes.” BioMed Research International, Sept. 2020, pp. 1–11. EBSCOhost, doi:10.1155/2020/7929610.
    • Chicago/Turabian: Humanities:
      Lee, Soomin, Heeyoung Lee, Sejeong Kim, Jeeyeon Lee, Jimyeong Ha, Yukyung Choi, Hyemin Oh, et al. “Intestinal Clostridioides Difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes.” BioMed Research International, September 12, 2020, 1–11. doi:10.1155/2020/7929610.
    • Vancouver/ICMJE:
      Lee S, Lee H, Kim S, Lee J, Ha J, Choi Y, et al. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International [Internet]. 2020 Sep 12 [cited 2020 Dec 1];1–11. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=145717738