Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection.

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  • Additional Information
    • Affiliation:
      Lung Transplantation Research Unit, Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
      Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
      Laboratory of Morphology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
      Subdirection of Surgery, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
      Department of Otolaryngology-Head and Neck Surgery, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
      Department of Surgery, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City, Mexico
      External Consultation Service, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Treatment of tracheal stenosis is occasionally performed in combination with wound healing modulators to manipulate new extracellular matrix (ECM) formation and prevent fibrosis. Hyaluronic acid (HA) and collagen-polyvinylpyrrolidone (collagen-PVP) decrease fibrosis in experimental tracheal healing. However, they have not been used clinically as their effect on ECM components, which modify tracheal scarring, has not been described. Objective. To evaluate the effect of the application of HA, collagen-PVP, a mixture of HA and collagen-PVP (HA+collagen-PVP), and mitomycin C on the expression of decorin, matrix metalloproteinase 1 (MMP1), and MMP9, as well as the type of collagen and deposits formed in the scar after resection and end-to-end anastomosis (REEA) of the cervical trachea using an experimental model. Materials and Methods. Thirty dogs underwent REEA of the cervical trachea and were treated with different wound healing modulators: group I (n = 6), control; group II (n = 6), HA; group III (n = 6), collagen-PVP; group IV (n = 6), HA+collagen-PVP; and group V (n = 6), mitomycin C. The dogs were evaluated clinically and endoscopically for 4 weeks. Subsequently, macroscopic and microscopic changes, expression of ECM proteins, and collagen deposition in tracheal scars were analysed. Results. Groups II, III, and IV showed reduced endoscopic, macroscopic, and microscopic inflammation, improved neovascularization, high decorin expression (p < 0.01 , analysis of variance (ANOVA)), and moderate expression of MMP1 (p < 0.003 , ANOVA) and type I and III collagen (p < 0.05 , Kruskal–Wallis). Groups IV and V developed fewer collagen deposits (p < 0.001 , ANOVA). Conclusion. Treatment with HA and collagen-PVP improved post-REEA healing by increasing neovascularization, stimulating the expression of decorin, and regulating the expression of MMP1, as well as type I and III collagen and their deposition.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200902
    • Publication Date:
      20200902
    • DOI:
      10.1155/2020/3964518
    • Accession Number:
      145340380
  • Citations
    • ABNT:
      OLMOS-ZUÑIGA, J. R. et al. Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. BioMed Research International, [s. l.], p. 1–15, 2020. DOI 10.1155/2020/3964518. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=145340380. Acesso em: 29 out. 2020.
    • AMA:
      Olmos-Zuñiga JR, Baltazares-Lipp M, Hernández-Jiménez C, et al. Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. BioMed Research International. August 2020:1-15. doi:10.1155/2020/3964518
    • APA:
      Olmos-Zuñiga, J. R., Baltazares-Lipp, M., Hernández-Jiménez, C., Jasso-Victoria, R., Gaxiola-Gaxiola, M., Silva-Martínez, M., Iñiguez-García, M. A., González-González, A. I., Vázquez-Minero, J. C., Luna-Flores, A., Solis-Alanis, N., & Baltazares-Lipp, M. E. (2020). Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. BioMed Research International, 1–15. https://doi.org/10.1155/2020/3964518
    • Chicago/Turabian: Author-Date:
      Olmos-Zuñiga, J. Raúl, Matilde Baltazares-Lipp, Claudia Hernández-Jiménez, Rogelio Jasso-Victoria, Miguel Gaxiola-Gaxiola, Mariana Silva-Martínez, Marco Antonio Iñiguez-García, et al. 2020. “Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection.” BioMed Research International, August, 1–15. doi:10.1155/2020/3964518.
    • Harvard:
      Olmos-Zuñiga, J. R. et al. (2020) ‘Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection’, BioMed Research International, pp. 1–15. doi: 10.1155/2020/3964518.
    • Harvard: Australian:
      Olmos-Zuñiga, JR, Baltazares-Lipp, M, Hernández-Jiménez, C, Jasso-Victoria, R, Gaxiola-Gaxiola, M, Silva-Martínez, M, Iñiguez-García, MA, González-González, AI, Vázquez-Minero, JC, Luna-Flores, A, Solis-Alanis, N & Baltazares-Lipp, ME 2020, ‘Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection’, BioMed Research International, pp. 1–15, viewed 29 October 2020, .
    • MLA:
      Olmos-Zuñiga, J.Raúl, et al. “Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection.” BioMed Research International, Aug. 2020, pp. 1–15. EBSCOhost, doi:10.1155/2020/3964518.
    • Chicago/Turabian: Humanities:
      Olmos-Zuñiga, J. Raúl, Matilde Baltazares-Lipp, Claudia Hernández-Jiménez, Rogelio Jasso-Victoria, Miguel Gaxiola-Gaxiola, Mariana Silva-Martínez, Marco Antonio Iñiguez-García, et al. “Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection.” BioMed Research International, August 27, 2020, 1–15. doi:10.1155/2020/3964518.
    • Vancouver/ICMJE:
      Olmos-Zuñiga JR, Baltazares-Lipp M, Hernández-Jiménez C, Jasso-Victoria R, Gaxiola-Gaxiola M, Silva-Martínez M, et al. Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. BioMed Research International [Internet]. 2020 Aug 27 [cited 2020 Oct 29];1–15. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=145340380