Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam.

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  • Additional Information
    • Affiliation:
      School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
      London School of Hygiene and Tropical Medicine, London, UK.
      Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
      Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
      Swedish Environmental Protection Agency, Stockholm, Sweden.
      Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      BACKGROUND: Firefighting foam-contaminated ground water, which contains high levels of perfluoroalkyl substances (PFAS), is frequently found around airports. In 2018 it was detected that employees at a municipal airport in northern Sweden had been exposed to high levels of short-chain PFAS along with legacy PFAS (i.e., PFOA, PFHxS, and PFOS) through drinking water. OBJECTIVES: In this study, we aimed to describe the PFAS profile in drinking water and biological samples (paired serum and urine) and to estimate serum half-lives of the short-chain PFAS together with legacy PFAS. METHODS: Within 2 weeks after provision of clean water, blood sampling was performed in all 26 airport employees. Seventeen of them were then followed up monthly for 5 months. PFHxA, PFHpA, PFBS, PFPeS, and PFHpS together with legacy PFAS in water and biological samples were quantified using LC/MS/MS. Half-lives were estimated by assuming one compartment, first-order elimination kinetics. RESULTS: The proportions of PFHxA, PFHpA, and PFBS were higher in drinking water than in serum. The opposite was found for PFHxS and PFOS. The legacy PFAS accounted for about 50% of total PFAS in drinking water and 90% in serum. Urinary PFAS levels were very low compared with serum. PFBS showed the shortest half-life {average 44 d [95% confidence interval (CI): 37, 55 d]}, followed by PFHpA [62 d (95% CI: 51, 80d)]. PFPeS and PFHpS showed average half-lives as 0.63 and 1.46 y, respectively. Branched PFOS isomers had average half-lives ranging from 1.05 to 1.26 y for different isomers. PFOA, PFHxS, and linear PFOS isomers showed average half-lives of 1.77, 2.87, and 2.93 y, respectively. DISCUSSION: A general pattern of increasing half-lives with increasing chain length was observed. Branched PFOS isomers had shorter half-lives than linear PFOS isomers.
    • Journal Subset:
      Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA
    • ISSN:
      0091-6765
    • MEDLINE Info:
      NLM UID: 0330411
    • Grant Information:
      The study was funded by the Swedish Environmental Protection Agency and Swedish Research Council FORMAS grant 2017-00875.
    • Publication Date:
      20200821
    • Publication Date:
      20200827
    • DOI:
      10.1289/EHP6785
    • Accession Number:
      145196647
  • Citations
    • ABNT:
      YIYI XU et al. Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam. Environmental Health Perspectives, [s. l.], v. 128, n. 7, p. 077004-1-077004-11, 2020. DOI 10.1289/EHP6785. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=145196647. Acesso em: 1 dez. 2020.
    • AMA:
      Yiyi Xu, Fletcher T, Pineda D, et al. Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam. Environmental Health Perspectives. 2020;128(7):077004-1-077004-11. doi:10.1289/EHP6785
    • APA:
      Yiyi Xu, Fletcher, T., Pineda, D., Lindh, C. H., Nilsson, C., Glynn, A., Vogs, C., Lilja, K., Jakobsson, K., & Ying Li. (2020). Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam. Environmental Health Perspectives, 128(7), 077004-1-077004-11. https://doi.org/10.1289/EHP6785
    • Chicago/Turabian: Author-Date:
      Yiyi Xu, Tony Fletcher, Daniela Pineda, Christian H. Lindh, Carina Nilsson, Anders Glynn, Carolina Vogs, Karl Lilja, Kristina Jakobsson, and Ying Li. 2020. “Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam.” Environmental Health Perspectives 128 (7): 077004-1-077004-11. doi:10.1289/EHP6785.
    • Harvard:
      Yiyi Xu et al. (2020) ‘Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam’, Environmental Health Perspectives, 128(7), pp. 077004-1-077004-11. doi: 10.1289/EHP6785.
    • Harvard: Australian:
      Yiyi Xu, Fletcher, T, Pineda, D, Lindh, CH, Nilsson, C, Glynn, A, Vogs, C, Lilja, K, Jakobsson, K & Ying Li 2020, ‘Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam’, Environmental Health Perspectives, vol. 128, no. 7, pp. 077004-1-077004-11, viewed 1 December 2020, .
    • MLA:
      Yiyi Xu, et al. “Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam.” Environmental Health Perspectives, vol. 128, no. 7, July 2020, pp. 077004-1-077004-11. EBSCOhost, doi:10.1289/EHP6785.
    • Chicago/Turabian: Humanities:
      Yiyi Xu, Tony Fletcher, Daniela Pineda, Christian H. Lindh, Carina Nilsson, Anders Glynn, Carolina Vogs, Karl Lilja, Kristina Jakobsson, and Ying Li. “Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam.” Environmental Health Perspectives 128, no. 7 (July 2020): 077004-1-077004-11. doi:10.1289/EHP6785.
    • Vancouver/ICMJE:
      Yiyi Xu, Fletcher T, Pineda D, Lindh CH, Nilsson C, Glynn A, et al. Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam. Environmental Health Perspectives [Internet]. 2020 Jul [cited 2020 Dec 1];128(7):077004-1-077004-11. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=145196647