Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study.

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  • Additional Information
    • Affiliation:
      Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
      Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Taiwan
      Graduate Institute of Clinical Medicine, Department of Environmental Health, Kaohsiung Medical University, Kaohsiung, Taiwan
      National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Taiwan
      Digestive Disease Center, Show Chwan Memorial Hospital, Changhua, Taiwan
      Research Assistant Center, Show Chwan Health Care System, Changhua, Taiwan
      Department of Medical Research and Development, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan
      Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
      Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
      Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
      Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Gout is the most prevalent inflammatory arthritis in adults. Although the link between gout and type 2 diabetes mellitus (T2DM) has been documented, our understanding of the association between urate-lowering therapy (ULT) among gout patients and T2DM development remains poor. We included 69,326 patients with new-onset gout in 2000-2011. Each case was matched randomly with 1 patient without gout during the study period, and 69,326 patients were recognized as the comparison cohort. A Cox proportional hazard regression model was used to analyze differences in the risk of T2DM development between patients with and without gout after considering related comorbidities. After adjusting for potential confounders, the case group had a higher risk of T2DM than the control cohort (adjusted hazard ratio aHR = 1.30 , 95 % confidence interval CI = 1.24 -1.38; P < 0.001). Gout patients without appropriate ULT had significantly higher risk of T2DM development than the control cohort (aHR = 1.39 ; 95 % CI = 1.30 -1.48; P < 0.001). Among gout patients, those receiving ULT excluding probenecid (aHR = 0.80 ; 95 % CI = 0.64 -1.00), all had significantly lower risk of T2DM than gout patients without ULT (all aHR < 0.90 ; all P < 0.001). In this study, we found that gout increased the risk of T2DM; however, patients with any ULT exhibited a lower risk of T2DM than gout patients without any ULT (all aHR < 0.90 , P < 0.001 ; excluding probenecid).
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200731
    • Publication Date:
      20200731
    • DOI:
      10.1155/2020/6358954
    • Accession Number:
      144798078
  • Citations
    • ABNT:
      FANG, Y.-J. et al. Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study. BioMed Research International, [s. l.], p. 1–7, 2020. DOI 10.1155/2020/6358954. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144798078. Acesso em: 25 set. 2020.
    • AMA:
      Fang Y-J, Chung Y-L, Lin C-L, Lim Y-P. Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study. BioMed Research International. July 2020:1-7. doi:10.1155/2020/6358954
    • APA:
      Fang, Y.-J., Chung, Y.-L., Lin, C.-L., & Lim, Y.-P. (2020). Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study. BioMed Research International, 1–7. https://doi.org/10.1155/2020/6358954
    • Chicago/Turabian: Author-Date:
      Fang, Yi-Jen, Yun-Lung Chung, Cheng-Li Lin, and Yun-Ping Lim. 2020. “Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study.” BioMed Research International, July, 1–7. doi:10.1155/2020/6358954.
    • Harvard:
      Fang, Y.-J. et al. (2020) ‘Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study’, BioMed Research International, pp. 1–7. doi: 10.1155/2020/6358954.
    • Harvard: Australian:
      Fang, Y-J, Chung, Y-L, Lin, C-L & Lim, Y-P 2020, ‘Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study’, BioMed Research International, pp. 1–7, viewed 25 September 2020, .
    • MLA:
      Fang, Yi-Jen, et al. “Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study.” BioMed Research International, July 2020, pp. 1–7. EBSCOhost, doi:10.1155/2020/6358954.
    • Chicago/Turabian: Humanities:
      Fang, Yi-Jen, Yun-Lung Chung, Cheng-Li Lin, and Yun-Ping Lim. “Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study.” BioMed Research International, July 28, 2020, 1–7. doi:10.1155/2020/6358954.
    • Vancouver/ICMJE:
      Fang Y-J, Chung Y-L, Lin C-L, Lim Y-P. Association between Gout, Urate-Lowering Therapy, and Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study. BioMed Research International [Internet]. 2020 Jul 28 [cited 2020 Sep 25];1–7. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144798078