Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Affiliation:
      Department of Oriental Neuropsychiatry, Dong-eui University College of Korean Medicine, 62 Yangjeong-ro, Busanjin-gu, Busan 47227, Republic of Korea
      Clinical Medicine Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea
      Guideline Center for Korean Medicine, National Institute for Korean Medicine Development, 173 Toegye-ro, Jung-gu, Seoul 04554, Republic of Korea
      Department of Ophthalmology and Otolaryngology and Dermatology, School of Korean Medicine, Pusan National University, 20 Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, Republic of Korea
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Objectives. Herbal medicine (HM) is attracting attention for treating atopic dermatitis (AD). This overview was conducted to summarize and critically evaluate the current systematic reviews (SRs) on HM for the treatment of AD. Methods. Through comprehensive searches, all relevant SRs on HM for AD published until May 2020 were included. The quality of included SRs was assessed using the AMSTAR-2 tool. Moreover, original randomized controlled trials (RCTs) included in the SRs were resynthesized to investigate the efficacy and safety of oral HM for AD. The quality of evidence for the main findings was evaluated using the GRADE approach. Results. Nine SRs were included in this overview. HM showed significantly better efficacy in terms of total effective rate (TER), itching and sleep symptom scores, quality of life, and the dose of topical treatment used compared with placebo. HM as a monotherapy and/or an adjunctive therapy to conventional medication (CM) showed significantly better results on the efficacy, symptom relief, and some laboratory parameters related to the inflammatory response. The methodological quality was generally low. When 58 original RCTs were reanalyzed, HM showed significantly lower SCORing Atopic Dermatitis (SCORAD) score and higher TER than the placebo or CM. In terms of the safety profile, HM was not significantly different from the placebo and was better than CM. The quality of evidence ranged from "moderate" to "very low." Conclusion. The results suggested that HM as a monotherapy or an adjunctive therapy is promising for the treatment of AD. However, due to low methodological quality and low quality of evidence, further rigorous, well-designed, high-quality SRs, and RCTs are needed to make clinical recommendations on HM use.
    • Journal Subset:
      Alternative/Complementary Therapies; Biomedical; Europe; Peer Reviewed; UK & Ireland
    • Special Interest:
      Evidence-Based Practice
    • ISSN:
      1741-427X
    • MEDLINE Info:
      NLM UID: 101215021
    • Publication Date:
      20200724
    • Publication Date:
      20200724
    • DOI:
      http://dx.doi.org/10.1155/2020/4140692
    • Accession Number:
      144613699
  • Citations
    • ABNT:
      KWON, C.-Y. et al. Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews. Evidence-based Complementary & Alternative Medicine (eCAM), [s. l.], p. 1–15, 2020. DOI 10.1155/2020/4140692. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144613699. Acesso em: 23 set. 2020.
    • AMA:
      Kwon C-Y, Lee B, Kim S, Lee J, Park M, Kim N. Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews. Evidence-based Complementary & Alternative Medicine (eCAM). July 2020:1-15. doi:10.1155/2020/4140692
    • APA:
      Kwon, C.-Y., Lee, B., Kim, S., Lee, J., Park, M., & Kim, N. (2020). Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews. Evidence-Based Complementary & Alternative Medicine (ECAM), 1–15. https://doi.org/10.1155/2020/4140692
    • Chicago/Turabian: Author-Date:
      Kwon, Chan-Young, Boram Lee, Suran Kim, Jaesuk Lee, Minjung Park, and Namkwen Kim. 2020. “Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews.” Evidence-Based Complementary & Alternative Medicine (ECAM), July, 1–15. doi:10.1155/2020/4140692.
    • Harvard:
      Kwon, C.-Y. et al. (2020) ‘Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews’, Evidence-based Complementary & Alternative Medicine (eCAM), pp. 1–15. doi: 10.1155/2020/4140692.
    • Harvard: Australian:
      Kwon, C-Y, Lee, B, Kim, S, Lee, J, Park, M & Kim, N 2020, ‘Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews’, Evidence-based Complementary & Alternative Medicine (eCAM), pp. 1–15, viewed 23 September 2020, .
    • MLA:
      Kwon, Chan-Young, et al. “Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews.” Evidence-Based Complementary & Alternative Medicine (ECAM), July 2020, pp. 1–15. EBSCOhost, doi:10.1155/2020/4140692.
    • Chicago/Turabian: Humanities:
      Kwon, Chan-Young, Boram Lee, Suran Kim, Jaesuk Lee, Minjung Park, and Namkwen Kim. “Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews.” Evidence-Based Complementary & Alternative Medicine (ECAM), July 17, 2020, 1–15. doi:10.1155/2020/4140692.
    • Vancouver/ICMJE:
      Kwon C-Y, Lee B, Kim S, Lee J, Park M, Kim N. Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews. Evidence-based Complementary & Alternative Medicine (eCAM) [Internet]. 2020 Jul 17 [cited 2020 Sep 23];1–15. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144613699