Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women.

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  • Additional Information
    • Affiliation:
      Department of Big Data and Health Science, School of Public Health, Zhejiang University School of Medicine , Hangzhou, Zhejiang, China
      Department of Nutrition, Harvard T.H. Chan School of Public Health , Boston, MA, USA
      Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, MA, USA
      Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA, USA
      Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School , Boston, MA, USA
      Department of Epidemiology, Erasmus MC University Medical Center , Rotterdam, Netherlands
    • Abstract:
      Background: A protective association of dietary carotenoids with cognitive function has been suggested, but most studies have been relatively small with limited periods of follow-up.Objectives: We examined prospectively long-term intakes of carotenoids in relation to subjective cognitive function (SCF), a self-reported, validated indicator of cognitive dysfunction.Methods: Among 49,493 female registered nurses with a mean age of 48 y in 1984, we used multinomial logistic regression to estimate the ORs and 95% CIs relating intakes of carotenoids to self-reported SCF in 2012 and 2014. Mean intakes of carotenoids were calculated from 7 repeated FFQs collected in 1984, 1986, and every 4 y afterwards until 2006. Self-reported SCF was assessed by a 7-item questionnaire on changes in memory and cognition; validity was supported by strong associations with Apolipoprotein E (APOE) ε4 genotype and concurrent cognitive function and cognitive decline measured by telephone-based neuropsychological tests. The mean values of scores assessed in 2012 and 2014 were categorized as "good" (0 points, 40.8%), "moderate" (0.5-2.5 points, 46.9%), and "poor" (3-7 points, 12.3%).Results: Higher intake of total carotenoids was associated with substantially lower odds of moderate or poor cognitive function after controlling for other dietary and nondietary risk factors and total energy intake. Comparing the top with the bottom quintile of total carotenoids, the multivariable ORs were 0.86 (95% CI: 0.80, 0.93; P-trend < 0.001) for moderate SCF and 0.67 (95% CI: 0.60, 0.75; P-trend < 0.001) for poor SCF. This lower OR was also seen for carotenoids consumed 28 y before SCF assessment. Similar associations were found for total β-carotene, dietary β-carotene, α-carotene, lycopene, lutein + zeaxanthin, and β-cryptoxanthin. The significant associations for β-cryptoxanthin, lycopene, and lutein + zeaxanthin persisted after mutual adjustment for each other.Conclusions: Our findings support a long-term beneficial role of carotenoid consumption on cognitive function in women.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      0022-3166
    • MEDLINE Info:
      PMID: NLM32386230 NLM UID: 0404243
    • Grant Information:
      P30 DK040561/DK/NIDDK NIH HHS/United States
    • Publication Date:
      In Process
    • Publication Date:
      20200717
    • DOI:
      http://dx.doi.org/10.1093/jn/nxaa087
    • Accession Number:
      144429009
  • Citations
    • ABNT:
      YUAN, C. et al. Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women. Journal of Nutrition, [s. l.], v. 150, n. 7, p. 1871–1879, 2020. DOI 10.1093/jn/nxaa087. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144429009. Acesso em: 15 ago. 2020.
    • AMA:
      Yuan C, Fondell E, Ascherio A, et al. Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women. Journal of Nutrition. 2020;150(7):1871-1879. doi:10.1093/jn/nxaa087
    • APA:
      Yuan, C., Fondell, E., Ascherio, A., Okereke, O. I., Grodstein, F., Hofman, A., & Willett, W. C. (2020). Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women. Journal of Nutrition, 150(7), 1871–1879. https://doi.org/10.1093/jn/nxaa087
    • Chicago/Turabian: Author-Date:
      Yuan, Changzheng, Elinor Fondell, Alberto Ascherio, Olivia I Okereke, Francine Grodstein, Albert Hofman, and Walter C Willett. 2020. “Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women.” Journal of Nutrition 150 (7): 1871–79. doi:10.1093/jn/nxaa087.
    • Harvard:
      Yuan, C. et al. (2020) ‘Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women’, Journal of Nutrition, 150(7), pp. 1871–1879. doi: 10.1093/jn/nxaa087.
    • Harvard: Australian:
      Yuan, C, Fondell, E, Ascherio, A, Okereke, OI, Grodstein, F, Hofman, A & Willett, WC 2020, ‘Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women’, Journal of Nutrition, vol. 150, no. 7, pp. 1871–1879, viewed 15 August 2020, .
    • MLA:
      Yuan, Changzheng, et al. “Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women.” Journal of Nutrition, vol. 150, no. 7, July 2020, pp. 1871–1879. EBSCOhost, doi:10.1093/jn/nxaa087.
    • Chicago/Turabian: Humanities:
      Yuan, Changzheng, Elinor Fondell, Alberto Ascherio, Olivia I Okereke, Francine Grodstein, Albert Hofman, and Walter C Willett. “Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women.” Journal of Nutrition 150, no. 7 (July 2020): 1871–79. doi:10.1093/jn/nxaa087.
    • Vancouver/ICMJE:
      Yuan C, Fondell E, Ascherio A, Okereke OI, Grodstein F, Hofman A, et al. Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women. Journal of Nutrition [Internet]. 2020 Jul [cited 2020 Aug 15];150(7):1871–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144429009