Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma.

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  • Additional Information
    • Affiliation:
      Department of Pathology and IBSAL, University Hospital of Salamanca, Salamanca, Spain
      Department of Pathology, University Hospital of Salamanca, Salamanca, Spain
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Ewing sarcomas are an uncommon group of malignant neoplasms. A multidisciplinary approach is highly recommended to reach a correct diagnosis, considering the clinical, radiological, and histopathological aspects. Since in up to 90% of cases, the translocation t (11; 22) (q24; q12) occurs resulting in a chimeric fusion transcript EWSR1-FLI-1. The pathologist has several tools in addition to conventional techniques (hematoxylin and eosin), such as immunohistochemistry, which plays a very important role in the differential diagnosis. We present a series of 15 cases of molecularly confirmed ES, in which we found a sensitivity of 100% for CD99 and 80% for PAX8 by immunohistochemistry. This indicates a high sensitivity; however, it is known that both CD99 and PAX8 are also expressed in other tumours. Therefore, molecular confirmation should be performed in all cases.
    • Journal Subset:
      Biomedical; Europe; Peer Reviewed; UK & Ireland
    • ISSN:
      1357-714X
    • MEDLINE Info:
      NLM UID: 9709257
    • Publication Date:
      20200703
    • Publication Date:
      20200703
    • DOI:
      10.1155/2020/3180798
    • Accession Number:
      144303622
  • Citations
    • ABNT:
      CHINCHILLA-TÁBORA, L. et al. Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma. Sarcoma, [s. l.], p. 1–6, 2020. DOI 10.1155/2020/3180798. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144303622. Acesso em: 3 dez. 2020.
    • AMA:
      Chinchilla-Tábora L, Ortiz Rodríguez-Parets J, González Morais I, Sayagués JM, Ludeña de la Cruz MD. Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma. Sarcoma. June 2020:1-6. doi:10.1155/2020/3180798
    • APA:
      Chinchilla-Tábora, L., Ortiz Rodríguez-Parets, J., González Morais, I., Sayagués, J. M., & Ludeña de la Cruz, M. D. (2020). Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma. Sarcoma, 1–6. https://doi.org/10.1155/2020/3180798
    • Chicago/Turabian: Author-Date:
      Chinchilla-Tábora, LM., J. Ortiz Rodríguez-Parets, I. González Morais, J. M. Sayagués, and M. D. Ludeña de la Cruz. 2020. “Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma.” Sarcoma, June, 1–6. doi:10.1155/2020/3180798.
    • Harvard:
      Chinchilla-Tábora, L. et al. (2020) ‘Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma’, Sarcoma, pp. 1–6. doi: 10.1155/2020/3180798.
    • Harvard: Australian:
      Chinchilla-Tábora, L, Ortiz Rodríguez-Parets, J, González Morais, I, Sayagués, JM & Ludeña de la Cruz, MD 2020, ‘Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma’, Sarcoma, pp. 1–6, viewed 3 December 2020, .
    • MLA:
      Chinchilla-Tábora, LM., et al. “Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma.” Sarcoma, June 2020, pp. 1–6. EBSCOhost, doi:10.1155/2020/3180798.
    • Chicago/Turabian: Humanities:
      Chinchilla-Tábora, LM., J. Ortiz Rodríguez-Parets, I. González Morais, J. M. Sayagués, and M. D. Ludeña de la Cruz. “Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma.” Sarcoma, June 29, 2020, 1–6. doi:10.1155/2020/3180798.
    • Vancouver/ICMJE:
      Chinchilla-Tábora L, Ortiz Rodríguez-Parets J, González Morais I, Sayagués JM, Ludeña de la Cruz MD. Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma. Sarcoma [Internet]. 2020 Jun 29 [cited 2020 Dec 3];1–6. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144303622