Effects of parental mental illness on children's physical health: systematic review and meta-analysis.

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  • Additional Information
    • Affiliation:
      Research Fellow, Centre for Women's Mental Health, Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, UK
      Research Associate, Centre for Women's Mental Health, Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, UK
      Research Assistant, Centre for Women's Mental Health, Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, UK
      PhD Student, Centre for Women's Mental Health, Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, UK
      Clinical Research Fellow, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, UK
      Senior Consultant, Department of Public Health Sciences, Division Public Health Epidemiology, Karolinska Institutet, Stockholm
      Professor of Psychiatric Epidemiology and Research Group Leader, Department of Public Health Sciences, Division Public Health Epidemiology, Karolinska Institutet, Stockholm
      Winthrop Professor and Head, Neuropsychiatric Epidemiology Research Unit, Division of Psychiatry, University of Western Australia, Australia
      Research Fellow, Neuropsychiatric Epidemiology Research Unit, Division of Psychiatry, University of Western Australia, Australia
      Professor of Psychological Medicine and Director, Centre for Women's Mental Health, Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, UK
    • Abstract:
      Background: Children of parents with mental disorder face multiple challenges.Aims: To summarise evidence about parental mental disorder and child physical health.Method: We searched seven databases for cohort or case-control studies quantifying associations between parental mental disorders (substance use, psychotic, mood, anxiety, obsessive-compulsive, post-traumatic stress and eating) and offspring physical health. Studies were excluded if: they reported perinatal outcomes only (<28 days) or outcomes after age 18; they measured outcome prior to exposure; or the sample was drawn from diseased children. A meta-analysis was conducted. The protocol was registered on the PROSPERO database (CRD42017072620).Results: Searches revealed 15 945 non-duplicated studies. Forty-one studies met our inclusion criteria: ten investigated accidents/injuries; eight asthma; three other atopic diseases; ten overweight/obesity; ten studied other illnesses (eight from low-and middle-income countries (LMICs)). Half of the studies investigated maternal perinatal mental health, 17% investigated paternal mental disorder and 87% examined maternal depression. Meta-analysis revealed significantly higher rates of injuries (OR = 1.15, 95% CI 1.04-1.26), asthma (OR = 1.26, 95% CI 1.12-1.41) and outcomes recorded in LMICs (malnutrition: OR = 2.55, 95% CI 1.74-3.73; diarrhoea: OR = 2.16, 95% CI 1.65-2.84). Evidence was inconclusive for obesity and other atopic disorders.Conclusions: Children of parents with mental disorder have health disadvantages; however, the evidence base is limited to risks for offspring following postnatal depression in mothers and there is little focus on fathers in the literature. Understanding the physical health risks of these vulnerable children is vital to improving lives. Future work should focus on discovering mechanisms linking physical and mental health across generations.Declaration Of Interest: None.
    • Journal Subset:
      Biomedical; Europe; Peer Reviewed; UK & Ireland
    • ISSN:
      0007-1250
    • MEDLINE Info:
      PMID: NLM31610824 NLM UID: 0342367
    • Publication Date:
      In Process
    • Publication Date:
      20200703
    • DOI:
      10.1192/bjp.2019.216
    • Accession Number:
      144299106
  • Citations
    • ABNT:
      PIERCE, M. et al. Effects of parental mental illness on children’s physical health: systematic review and meta-analysis. British Journal of Psychiatry, [s. l.], v. 217, n. 1, p. 354–363, 2020. DOI 10.1192/bjp.2019.216. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144299106. Acesso em: 29 set. 2020.
    • AMA:
      Pierce M, Hope HF, Kolade A, et al. Effects of parental mental illness on children’s physical health: systematic review and meta-analysis. British Journal of Psychiatry. 2020;217(1):354-363. doi:10.1192/bjp.2019.216
    • APA:
      Pierce, M., Hope, H. F., Kolade, A., Gellatly, J., Osam, C. S., Perchard, R., Kosidou, K., Dalman, C., Morgan, V., Di Prinzio, P., & Abel, K. M. (2020). Effects of parental mental illness on children’s physical health: systematic review and meta-analysis. British Journal of Psychiatry, 217(1), 354–363. https://doi.org/10.1192/bjp.2019.216
    • Chicago/Turabian: Author-Date:
      Pierce, Matthias, Holly F. Hope, Adekeye Kolade, Judith Gellatly, Cemre Su Osam, Reena Perchard, Kyriaki Kosidou, et al. 2020. “Effects of Parental Mental Illness on Children’s Physical Health: Systematic Review and Meta-Analysis.” British Journal of Psychiatry 217 (1): 354–63. doi:10.1192/bjp.2019.216.
    • Harvard:
      Pierce, M. et al. (2020) ‘Effects of parental mental illness on children’s physical health: systematic review and meta-analysis’, British Journal of Psychiatry, 217(1), pp. 354–363. doi: 10.1192/bjp.2019.216.
    • Harvard: Australian:
      Pierce, M, Hope, HF, Kolade, A, Gellatly, J, Osam, CS, Perchard, R, Kosidou, K, Dalman, C, Morgan, V, Di Prinzio, P & Abel, KM 2020, ‘Effects of parental mental illness on children’s physical health: systematic review and meta-analysis’, British Journal of Psychiatry, vol. 217, no. 1, pp. 354–363, viewed 29 September 2020, .
    • MLA:
      Pierce, Matthias, et al. “Effects of Parental Mental Illness on Children’s Physical Health: Systematic Review and Meta-Analysis.” British Journal of Psychiatry, vol. 217, no. 1, July 2020, pp. 354–363. EBSCOhost, doi:10.1192/bjp.2019.216.
    • Chicago/Turabian: Humanities:
      Pierce, Matthias, Holly F. Hope, Adekeye Kolade, Judith Gellatly, Cemre Su Osam, Reena Perchard, Kyriaki Kosidou, et al. “Effects of Parental Mental Illness on Children’s Physical Health: Systematic Review and Meta-Analysis.” British Journal of Psychiatry 217, no. 1 (July 2020): 354–63. doi:10.1192/bjp.2019.216.
    • Vancouver/ICMJE:
      Pierce M, Hope HF, Kolade A, Gellatly J, Osam CS, Perchard R, et al. Effects of parental mental illness on children’s physical health: systematic review and meta-analysis. British Journal of Psychiatry [Internet]. 2020 Jul [cited 2020 Sep 29];217(1):354–63. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144299106