Rare genital malformations in women's health research: sociodemographic, regional, and disease-related characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome.

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  • Additional Information
    • Affiliation:
      University Hospital Tübingen, Department of Women's Health, Tübingen, Germany
      University Hospital Tübingen, Department of Women's Health, Research Institute for Women's Health, Tübingen, Germany
      University Hospital Tübingen, Institute for Health Sciences, Section of Midwifery Science, Tübingen, Germany
      Department for Psychiatry and Psychotherapy, University Hospital Tübingen, Tübingen, Germany
      University Hospital Tübingen, Internal Medicine, Department of Psychosomatic Medicine and Psychotherapy, Tübingen, Germany
      University of Tübingen, Department of Sociology, Tübingen, Germany
      University Hospital Tübingen, Institute of Occupational and Social Medicine and Health Services Research, Tübingen, Germany
      University Hospital Tübingen, Staff Section Social Medicine, Tübingen, Germany
    • Abstract:
      Background: The Mayer-Rokitansky-Küster-Hauser syndrome, MRKHS, is a rare (orphan) disease characterized by the aplasia or hypoplasia of the uterus and the vagina. In women's health research, little is known as to how much care provision for patients with MRKHS takes into account their socio-demographic together with their clinical characteristics. This work examines the patients' socio-demographic characteristics, highlighting issues of inappropriate and deficient provision of care.Methods: The study was carried out as part of the larger TransCareO project and included a group of N=129 MRKHS patients who underwent surgery between 2008 and 2012. Using a specially developed questionnaire, we analyzed MRKHS patients' data found both in the clinical documentation of the Department for Women's Health, University Hospital of Tübingen and the patient surveys of the Center for Rare Genital Malformations (CRGM/ ZSGF). Patients who took part in interviews were compared with non-respondents.Results: Patient respondents and non-respondents did not differ as to the parameters of interest. In most cases, primary amenorrhea was reported as an admission reason. In 24% of patients, a medical intervention (hymenal incision or hormone treatment) already occurred before admission to the Center in Tübingen and proper diagnosis of MRKHS. About one third received in advance inappropriate treatment. During the therapy, more than half of the patients were in a solid partnership. 10% of the family anamneses documented the occurrence of urogenital malformations.Conclusions: Care provision for MRKHS patients is largely characterized by delayed proper diagnosis and in part, by inappropriate treatment attempts; there are also indications of regional differences. Anamnestic clues such as an asymptomatic amenorrhea or renal abnormalities of unclear origin still fail to result early enough in referral to a center on the basis of suspected MRKHS diagnosis. Urogenital malformations in the family are more common in patients than in the general population. For patients, a wide range of burdens are associated with the diagnosis. Abnormalities compared to their female peers occur, for instance, in the partnership status: MRKHS patients have more rarely a partner.
    • Journal Subset:
      Biomedical; Europe; UK & Ireland
    • ISSN:
      1472-6874
    • MEDLINE Info:
      PMID: NLM32600323 NLM UID: 101088690
    • Grant Information:
      01GY1125//German Federal Ministry of Education and Research/
    • Publication Date:
      In Process
    • Publication Date:
      20200703
    • DOI:
      10.1186/s12905-020-00969-9
    • Accession Number:
      144295983
  • Citations
    • ABNT:
      BRUCKER, S. Y. et al. Rare genital malformations in women’s health research: sociodemographic, regional, and disease-related characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome. BMC Women’s Health, [s. l.], v. 20, n. 1, p. 1–10, 2020. DOI 10.1186/s12905-020-00969-9. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144295983. Acesso em: 25 set. 2020.
    • AMA:
      Brucker SY, Pösch L-S, Graf J, et al. Rare genital malformations in women’s health research: sociodemographic, regional, and disease-related characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome. BMC Women’s Health. 2020;20(1):1-10. doi:10.1186/s12905-020-00969-9
    • APA:
      Brucker, S. Y., Pösch, L.-S., Graf, J., Sokolov, A. N., Schaeffeler, N., Kronenthaler, A., Hiltner, H., Wagner, A., Ueding, E., Rieger, M. A., Schöller, D., Stefanescu, D., Rall, K. K., Wallwiener, D., & Simoes, E. (2020). Rare genital malformations in women’s health research: sociodemographic, regional, and disease-related characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome. BMC Women’s Health, 20(1), 1–10. https://doi.org/10.1186/s12905-020-00969-9
    • Chicago/Turabian: Author-Date:
      Brucker, Sara Yvonne, Leonie-Sophia Pösch, Joachim Graf, Alexander N. Sokolov, Norbert Schaeffeler, Andrea Kronenthaler, Hanna Hiltner, et al. 2020. “Rare Genital Malformations in Women’s Health Research: Sociodemographic, Regional, and Disease-Related Characteristics of Patients with Mayer-Rokitansky-Küster-Hauser Syndrome.” BMC Women’s Health 20 (1): 1–10. doi:10.1186/s12905-020-00969-9.
    • Harvard:
      Brucker, S. Y. et al. (2020) ‘Rare genital malformations in women’s health research: sociodemographic, regional, and disease-related characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome’, BMC Women’s Health, 20(1), pp. 1–10. doi: 10.1186/s12905-020-00969-9.
    • Harvard: Australian:
      Brucker, SY, Pösch, L-S, Graf, J, Sokolov, AN, Schaeffeler, N, Kronenthaler, A, Hiltner, H, Wagner, A, Ueding, E, Rieger, MA, Schöller, D, Stefanescu, D, Rall, KK, Wallwiener, D & Simoes, E 2020, ‘Rare genital malformations in women’s health research: sociodemographic, regional, and disease-related characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome’, BMC Women’s Health, vol. 20, no. 1, pp. 1–10, viewed 25 September 2020, .
    • MLA:
      Brucker, Sara Yvonne, et al. “Rare Genital Malformations in Women’s Health Research: Sociodemographic, Regional, and Disease-Related Characteristics of Patients with Mayer-Rokitansky-Küster-Hauser Syndrome.” BMC Women’s Health, vol. 20, no. 1, June 2020, pp. 1–10. EBSCOhost, doi:10.1186/s12905-020-00969-9.
    • Chicago/Turabian: Humanities:
      Brucker, Sara Yvonne, Leonie-Sophia Pösch, Joachim Graf, Alexander N. Sokolov, Norbert Schaeffeler, Andrea Kronenthaler, Hanna Hiltner, et al. “Rare Genital Malformations in Women’s Health Research: Sociodemographic, Regional, and Disease-Related Characteristics of Patients with Mayer-Rokitansky-Küster-Hauser Syndrome.” BMC Women’s Health 20, no. 1 (June 29, 2020): 1–10. doi:10.1186/s12905-020-00969-9.
    • Vancouver/ICMJE:
      Brucker SY, Pösch L-S, Graf J, Sokolov AN, Schaeffeler N, Kronenthaler A, et al. Rare genital malformations in women’s health research: sociodemographic, regional, and disease-related characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome. BMC Women’s Health [Internet]. 2020 Jun 29 [cited 2020 Sep 25];20(1):1–10. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144295983