Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation.

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  • Additional Information
    • Affiliation:
      Department of Pediatrics, Neonatology Division, University of Arkansas for Medical Sciences, Little Rock, Arkansas
      Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio
      Equilibrated Bio Systems, Smithtown, New York
      Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada
      Department of Medicine and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
      Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
      Institute for Biomedical Engineering and Science Technology, Ryerson University and St. Michael's Hospital, Toronto, Ontario, Canada
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      BACKGROUND: We tested whether work of breathing in premature newborns estimated by phase angle (h) by using respiratory inductance plethysmography is decreased during neurally-adjusted ventilatory assist (NAVA) noninvasive ventilation (NIV) versus NIV alone. METHODS: NAVA NIV and NIV were applied in random order while using respiratory inductance plethysmography to measure the phase angle. RESULTS: Patient-ventilator asynchrony was decreased during NAVA NIV; however, the phase angle was not different between the modes. A large number of repeated assists with switches to backup were found when using NAVA NIV. Results of the analysis indicated these were due to the apnea alarm limit set during NAVA NIV. CONCLUSIONS: The improvement in patient-ventilator synchrony supports the hypothesis that work of breathing may be decreased with NAVA NIV; however, we were unable to demonstrate this with our study design. Short apnea time settings with NAVA NIV led to a large number of switches to backup and repeated assists during the same neural effort. (ClinicalTrials.gov registration NCT02788110.)
    • Journal Subset:
      Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA
    • ISSN:
      0020-1324
    • MEDLINE Info:
      NLM UID: 7510357
    • Publication Date:
      20200626
    • Publication Date:
      20200630
    • DOI:
      http://dx.doi.org/10.4187/respcare.07257
    • Accession Number:
      144207922
  • Citations
    • ABNT:
      MATLOCK, D. N. et al. Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation. Respiratory Care, [s. l.], v. 65, n. 7, p. 946–953, 2020. DOI 10.4187/respcare.07257. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144207922. Acesso em: 10 ago. 2020.
    • AMA:
      Matlock DN, Bai S, Weisner MD, et al. Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation. Respiratory Care. 2020;65(7):946-953. doi:10.4187/respcare.07257
    • APA:
      Matlock, D. N., Bai, S., Weisner, M. D., Comtois, N., Beck, J., Sinderby, C., & Courtney, S. E. (2020). Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation. Respiratory Care, 65(7), 946–953. https://doi.org/10.4187/respcare.07257
    • Chicago/Turabian: Author-Date:
      Matlock, David N., Shasha Bai, Michael D. Weisner, Norman Comtois, Jennifer Beck, Christer Sinderby, and Sherry E. Courtney. 2020. “Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation.” Respiratory Care 65 (7): 946–53. doi:10.4187/respcare.07257.
    • Harvard:
      Matlock, D. N. et al. (2020) ‘Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation’, Respiratory Care, 65(7), pp. 946–953. doi: 10.4187/respcare.07257.
    • Harvard: Australian:
      Matlock, DN, Bai, S, Weisner, MD, Comtois, N, Beck, J, Sinderby, C & Courtney, SE 2020, ‘Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation’, Respiratory Care, vol. 65, no. 7, pp. 946–953, viewed 10 August 2020, .
    • MLA:
      Matlock, David N., et al. “Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation.” Respiratory Care, vol. 65, no. 7, July 2020, pp. 946–953. EBSCOhost, doi:10.4187/respcare.07257.
    • Chicago/Turabian: Humanities:
      Matlock, David N., Shasha Bai, Michael D. Weisner, Norman Comtois, Jennifer Beck, Christer Sinderby, and Sherry E. Courtney. “Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation.” Respiratory Care 65, no. 7 (July 2020): 946–53. doi:10.4187/respcare.07257.
    • Vancouver/ICMJE:
      Matlock DN, Bai S, Weisner MD, Comtois N, Beck J, Sinderby C, et al. Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation. Respiratory Care [Internet]. 2020 Jul [cited 2020 Aug 10];65(7):946–53. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=144207922