Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA meeting.

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  • Additional Information
    • Affiliation:
      Department of Oncology, Binzhou Medical University Hospital, The Yellow River Two Road No. 661, Binzhou, 256603 Shandong, China
      Department of Radiation Oncology, Gustave Roussy Cancer Campus, 94800 Villejuif, France
      Department of Radiology, Binzhou Medical University Hospital, The Yellow River Two Road No. 661, Binzhou, 256603 Shandong, China
      Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated to Nanjing Medical University, The Xinglong Xiang, No. 29, Changzhou, 213000 Jiangsu, China
      Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Jiyan Road No. 440, Jinan, 250117 Shandong, China
      Shandong Cancer Hospital and Institute-Shandong Cancer Hospital Affiliated to Shandong University, Jiyan Road No. 440, Jinan, 250117 Shandong, China
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background. Concurrent chemoradiotherapy (CCRT) is the main treatment for esophageal cancer, but the response to treatment varies from individual to individual. MR imaging methods, such as diffusion-weighted (DW) MRI and the use of dynamic contrast-enhanced (DCE) MRI, have the potential to provide additional biomarkers that could evaluate the effect of CCRT in patients with esophageal carcinoma. Materials and Methods. Fifty-six patients with esophageal carcinoma, verified by histopathology, underwent MRI examination before and at midtreatment (4th week, radiotherapy 30–40 Gy) using the Siemens 3.0 T MR System. Parameter maps of apparent diffusion coefficient (ADC), and DCE maps of volume transfer constant ( K rans ), rate contrast ( k ep ), and extracellular fluid space ( v e ), were computed using a Siemens Company Multimodality Workplace (MMWP) model. Comparison of histogram parameters and their diagnostic performance was determined using the Mann–Whitney U test and receiver operating characteristic (ROC) analysis. Results. 56 patient MRI scans were available for analysis at baseline and at the third week, respectively. Pretreatment K rans , pretreatment k ep , pretreatment ADC (P < 0.05), and during-treatment K rans (P < 0.05) and Δ K rans and ΔADC (P < 0.05) were significantly different after CCRT. Based on the binary logistic model, the ROC analysis demonstrated that the combined predictors demonstrated a high diagnostic performance with an AUC of 0.939. The sensitivity and specificity were 98.6% and 73.8%, respectively. Conclusion. The combination of DCE and DWI can be used as an early biomarker in the prediction of the effect of CCRT three weeks after treatment in esophageal carcinoma.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200619
    • Publication Date:
      20200619
    • DOI:
      http://dx.doi.org/10.1155/2020/2576563
    • Accession Number:
      143804539
  • Citations
    • ABNT:
      LIU, C. et al. Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA meeting. BioMed Research International, [s. l.], p. 1–9, 2020. DOI 10.1155/2020/2576563. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143804539. Acesso em: 15 ago. 2020.
    • AMA:
      Liu C, Sun R, Wang J, et al. Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA meeting. BioMed Research International. June 2020:1-9. doi:10.1155/2020/2576563
    • APA:
      Liu, C., Sun, R., Wang, J., Ning, F., Wang, Z., Luo, J., Chen, S., & Yuan, S. (2020). Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA meeting. BioMed Research International, 1–9. https://doi.org/10.1155/2020/2576563
    • Chicago/Turabian: Author-Date:
      Liu, Changmin, Roger Sun, Jing Wang, Fangling Ning, Zhenbo Wang, Judong Luo, Shaoshui Chen, and Shuanghu Yuan. 2020. “Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA Meeting.” BioMed Research International, June, 1–9. doi:10.1155/2020/2576563.
    • Harvard:
      Liu, C. et al. (2020) ‘Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA meeting’, BioMed Research International, pp. 1–9. doi: 10.1155/2020/2576563.
    • Harvard: Australian:
      Liu, C, Sun, R, Wang, J, Ning, F, Wang, Z, Luo, J, Chen, S & Yuan, S 2020, ‘Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA meeting’, BioMed Research International, pp. 1–9, viewed 15 August 2020, .
    • MLA:
      Liu, Changmin, et al. “Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA Meeting.” BioMed Research International, June 2020, pp. 1–9. EBSCOhost, doi:10.1155/2020/2576563.
    • Chicago/Turabian: Humanities:
      Liu, Changmin, Roger Sun, Jing Wang, Fangling Ning, Zhenbo Wang, Judong Luo, Shaoshui Chen, and Shuanghu Yuan. “Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA Meeting.” BioMed Research International, June 16, 2020, 1–9. doi:10.1155/2020/2576563.
    • Vancouver/ICMJE:
      Liu C, Sun R, Wang J, Ning F, Wang Z, Luo J, et al. Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma...RSNA meeting. BioMed Research International [Internet]. 2020 Jun 16 [cited 2020 Aug 15];1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143804539