Neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Affiliation:
      Department of Emergency Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 1021 Tongil-Ro, Eunpyeong-gu, 03312, Seoul, Republic of Korea
      Department of Emergency Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271, Cheonbo-Ro, Uijeongbu-si, 11765, Gyeonggi-do, Republic of Korea
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background: Paricalcitol is known to attenuate ischemic-reperfusion injury of various organs. However, it is not known whether paricalcitol prevents neuronal injury after global cerebral ischemia. The purpose of this study is to investigate the neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia. Methods: This is a prospective, randomized experimental study. Male Sprague-Dawley rats that survived 10 min of four-vessel occlusion were randomly assigned to two treatment groups: one group was treated with paricalcitol 1 μg/kg IP, and the other was given an equivalent volume of normal saline IP. Drugs were administered at 5 min, 1 day, 2 days, and 3 days after ischemia. Neurologic function was assessed at 2 h, 1 day, 2 days, 3 days, and 4 days after ischemia. We tested motor function 3 days after ischemia using the rotarod test. Also, we tested memory function 4 days after ischemia using the passive avoidance test. We assessed neuronal degeneration in the hippocampus of surviving rats 4 days after ischemia. Results: Eight rats were allocated to each group. No significant differences were found between the groups in terms of survival rate, motor coordination, or memory function. The neurological function score 2-h post-ischemia was significantly higher in the paricalcitol group (p = 0.04). Neuronal degeneration was significantly less in the paricalcitol group compared with the control group (p = 0.01). Conclusions: Paricalcitol significantly attenuated neuronal injury in the hippocampus. Although motor coordination, memory function, and survival rate were not significantly improved by paricalcitol treatment in this study, paricalcitol remains a potential neuroprotective drug after global cerebral ischemia.
    • Journal Subset:
      Biomedical; Europe; UK & Ireland
    • ISSN:
      1865-1372
    • Publication Date:
      20200618
    • Publication Date:
      20200618
    • DOI:
      10.1186/s12245-020-00289-7
    • Accession Number:
      143699567
  • Citations
    • ABNT:
      KIM, S. W. et al. Neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia. International Journal of Emergency Medicine, [s. l.], v. 13, n. 1, p. 1–8, 2020. DOI 10.1186/s12245-020-00289-7. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143699567. Acesso em: 1 dez. 2020.
    • AMA:
      Kim SW, Oh JS, Park J, et al. Neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia. International Journal of Emergency Medicine. 2020;13(1):1-8. doi:10.1186/s12245-020-00289-7
    • APA:
      Kim, S. W., Oh, J. S., Park, J., Jeong, H. H., Oh, Y. M., Choi, S., & Choi, K. H. (2020). Neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia. International Journal of Emergency Medicine, 13(1), 1–8. https://doi.org/10.1186/s12245-020-00289-7
    • Chicago/Turabian: Author-Date:
      Kim, Sung Wook, Joo Suk Oh, Jungtaek Park, Hyun Ho Jeong, Young Min Oh, Semin Choi, and Kyoung Ho Choi. 2020. “Neuroprotective Effect of Paricalcitol in a Rat Model of Transient Global Cerebral Ischemia.” International Journal of Emergency Medicine 13 (1): 1–8. doi:10.1186/s12245-020-00289-7.
    • Harvard:
      Kim, S. W. et al. (2020) ‘Neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia’, International Journal of Emergency Medicine, 13(1), pp. 1–8. doi: 10.1186/s12245-020-00289-7.
    • Harvard: Australian:
      Kim, SW, Oh, JS, Park, J, Jeong, HH, Oh, YM, Choi, S & Choi, KH 2020, ‘Neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia’, International Journal of Emergency Medicine, vol. 13, no. 1, pp. 1–8, viewed 1 December 2020, .
    • MLA:
      Kim, Sung Wook, et al. “Neuroprotective Effect of Paricalcitol in a Rat Model of Transient Global Cerebral Ischemia.” International Journal of Emergency Medicine, vol. 13, no. 1, June 2020, pp. 1–8. EBSCOhost, doi:10.1186/s12245-020-00289-7.
    • Chicago/Turabian: Humanities:
      Kim, Sung Wook, Joo Suk Oh, Jungtaek Park, Hyun Ho Jeong, Young Min Oh, Semin Choi, and Kyoung Ho Choi. “Neuroprotective Effect of Paricalcitol in a Rat Model of Transient Global Cerebral Ischemia.” International Journal of Emergency Medicine 13, no. 1 (June 10, 2020): 1–8. doi:10.1186/s12245-020-00289-7.
    • Vancouver/ICMJE:
      Kim SW, Oh JS, Park J, Jeong HH, Oh YM, Choi S, et al. Neuroprotective effect of paricalcitol in a rat model of transient global cerebral ischemia. International Journal of Emergency Medicine [Internet]. 2020 Jun 10 [cited 2020 Dec 1];13(1):1–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143699567