Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Affiliation:
      VA RR&D National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System, OR
      Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, Portland
      Department of Communication Sciences and Disorders, Syracuse University, NY
      Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Purpose: Complaints of auditory perceptual deficits, such as tinnitus and difficulty understanding speech in background noise, among individuals with clinically normal audiograms present a perplexing problem for audiologists. One potential explanation for these "hidden" auditory deficits is loss of the synaptic connections between the inner hair cells and their afferent auditory nerve fiber targets, a condition that has been termed cochlear synaptopathy. In animal models, cochlear synaptopathy can occur due to aging or exposure to noise or ototoxic drugs and is associated with reduced auditory brainstem response (ABR) wave I amplitudes. Decreased ABR wave I amplitudes have been demonstrated among young military Veterans and non-Veterans with a history of firearm use, suggesting that humans may also experience noise-induced synaptopathy. However, the downstream consequences of synaptopathy are unclear. Method: To investigate how noise-induced reductions in wave I amplitude impact the central auditory system, the ABR, the middle latency response (MLR), and the late latency response (LLR) were measured in 65 young Veterans and non-Veterans with normal audiograms. Results: In response to a click stimulus, the MLR was weaker for Veterans compared to non-Veterans, but the LLR was not reduced. In addition, low ABR wave I amplitudes were associated with a reduced MLR, but with an increased LLR. Notably, Veterans reporting tinnitus showed the largest mean LLRs. Conclusions: These findings indicate that decreased peripheral auditory input leads to compensatory gain in the central auditory system, even among individuals with normal audiograms, and may impact auditory perception. This pattern of reduced MLR, but not LLR, was observed among Veterans even after statistical adjustment for sex and distortion product otoacoustic emission differences, suggesting that synaptic loss plays a role in the observed central gain.
    • Journal Subset:
      Allied Health; Peer Reviewed; USA
    • Instrumentation:
      Lifetime Exposure to Noise and Solvents-Questionnaire (LENS-Q)
    • ISSN:
      1059-0889
    • MEDLINE Info:
      NLM UID: 9114917
    • Grant Information:
      This study was funded by the Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service Awards C2104-W; and C9230-C; and by National Institute on Deafness and Other Communication Disorders Grant R01DC015240.
    • Publication Date:
      20200611
    • Publication Date:
      20200617
    • DOI:
      http://dx.doi.org/10.1044/2019_AJA-19-00060
    • Accession Number:
      143637992
  • Citations
    • ABNT:
      BRAMHALL, N. F. et al. Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms. American Journal of Audiology, [s. l.], v. 29, n. 2, p. 152–164, 2020. DOI 10.1044/2019_AJA-19-00060. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143637992. Acesso em: 12 ago. 2020.
    • AMA:
      Bramhall NF, Niemczak CE, Kampel SD, Billings CJ, McMillan GP. Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms. American Journal of Audiology. 2020;29(2):152-164. doi:10.1044/2019_AJA-19-00060
    • APA:
      Bramhall, N. F., Niemczak, C. E., Kampel, S. D., Billings, C. J., & McMillan, G. P. (2020). Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms. American Journal of Audiology, 29(2), 152–164. https://doi.org/10.1044/2019_AJA-19-00060
    • Chicago/Turabian: Author-Date:
      Bramhall, Naomi F., Christopher E. Niemczak, Sean D. Kampel, Curtis J. Billings, and Garnett P. McMillan. 2020. “Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms.” American Journal of Audiology 29 (2): 152–64. doi:10.1044/2019_AJA-19-00060.
    • Harvard:
      Bramhall, N. F. et al. (2020) ‘Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms’, American Journal of Audiology, 29(2), pp. 152–164. doi: 10.1044/2019_AJA-19-00060.
    • Harvard: Australian:
      Bramhall, NF, Niemczak, CE, Kampel, SD, Billings, CJ & McMillan, GP 2020, ‘Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms’, American Journal of Audiology, vol. 29, no. 2, pp. 152–164, viewed 12 August 2020, .
    • MLA:
      Bramhall, Naomi F., et al. “Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms.” American Journal of Audiology, vol. 29, no. 2, June 2020, pp. 152–164. EBSCOhost, doi:10.1044/2019_AJA-19-00060.
    • Chicago/Turabian: Humanities:
      Bramhall, Naomi F., Christopher E. Niemczak, Sean D. Kampel, Curtis J. Billings, and Garnett P. McMillan. “Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms.” American Journal of Audiology 29, no. 2 (June 2020): 152–64. doi:10.1044/2019_AJA-19-00060.
    • Vancouver/ICMJE:
      Bramhall NF, Niemczak CE, Kampel SD, Billings CJ, McMillan GP. Evoked Potentials Reveal Noise Exposure--Related Central Auditory Changes Despite Normal Audiograms. American Journal of Audiology [Internet]. 2020 Jun [cited 2020 Aug 12];29(2):152–64. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143637992