Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus.

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  • Additional Information
    • Affiliation:
      Department of Chemistry, University of Swabi, Swabi-Anbar-, 23430 KPK, Pakistan
      Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University of Science and Technology, Al Ain Campus, UAE
      Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan
      Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia
      Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 42, Saudi Arabia
      University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan
      Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia
      Department of Laboratory Sciences, College of Sciences and Arts at Al-Rass, Qassim University, Saudi Arabia
      Department of Biological Sciences, Al-Hussein Bin Talal University, Maan, Jordan
      Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, 61421, Saudi Arabia
      Research Center for Advanced Materials Sciences (RCAMS), King Khalid University, 61413-Abha, 6113, Saudi Arabia
      Laboratory of Biocontrol and Antimicrobial Resistance, Orel State University Named after I.S. Turgenev, 302026 Orel, Russia
      European Society of Clinical Microbiology and Infectious Diseases, Basel 4051, Switzerland
      All Russian Research Institute of Phytopathology, Moscow Region 143050, Russia
      Department of Pharmacy, Southeast University, Dhaka, Bangladesh
      Pharmakon Neuroscience Research Network, Dhaka, Bangladesh
      Department of Plant Biology, Faculty of Science, University of Yaounde 1 & Institute of Agricultural Research for Development (IRAD), Cameroon
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Diospyros lotus, also known as date-plum, belongs to the Ebenaceae family and is mostly recognized as a rootstock for D. kaki. Similar classes of naphthoquinones in D. lotus are investigated against cancer and inflammation and have antimicrobial, sedative, and analgesic properties. Six chemical constituents (1-6) were isolated from Diospyros lotus and tested for anti-inflammatory effects at the dose of 2.5 and 5 mg/kg, i.p., using carrageenan (1%, 0.05 ml)-induced paw edema. The maximum protection against carrageenan-induced edema was observed for compounds 1 and 2. Both studied compounds demonstrated significant anti-inflammatory effect after the 3rd hour of posttreatment. The maximum anti-inflammatory effect of compound 1 was 85.96%, while that of compound 2 was 81.44%, followed by compounds 5 and 6, which exhibited 80.11% and 82.45% effect, respectively. Similarly, histamine-induced inflammation was significantly antagonized by 1, 2, 5, and 6 with 87.99%, 82.18 ± 1.8 , 80.40 ± 1.59 , and 77.44% effects, respectively, at 5 mg/kg after the 2nd hour of posttreatment. The rest of the tested compounds did not show any significant effect as compared to the negative control. Interestingly, no toxicity was observed at higher doses. Moreover, the extracted compounds showed remarkable antibacterial activity against the Gram-positive bacteria and no effect against the Gram-negative bacteria. Docking studies on target cyclooxygenases showed that all the compounds established interactions with the key amino acid residues present in the additional pocket of COX-2. Hence, these compounds may act as selective COX-2 inhibitors. In conclusion, the findings of the current study suggest that the roots of Diospyros lotus may contain some anti-inflammatory and antibacterial agents with minimal toxicological effects and accordingly this plant product is recommended for further investigations.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200611
    • Publication Date:
      20200611
    • DOI:
      http://dx.doi.org/10.1155/2020/7942549
    • Accession Number:
      143635481
  • Citations
    • ABNT:
      RAUF, A. et al. Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus. BioMed Research International, [s. l.], p. 1–10, 2020. DOI 10.1155/2020/7942549. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143635481. Acesso em: 15 ago. 2020.
    • AMA:
      Rauf A, Abu-Izneid T, Rashid U, et al. Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus. BioMed Research International. June 2020:1-10. doi:10.1155/2020/7942549
    • APA:
      Rauf, A., Abu-Izneid, T., Rashid, U., Alhumaydhi, F. A., Bawazeer, S., Khalil, A. A., Aljohani, A. S. M., Abdallah, E. M., Al-Tawaha, A. R., Mabkhot, Y. N., Shariati, M. A., Plygun, S., Uddin, M. S., & Ntsefong, G. N. (2020). Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus. BioMed Research International, 1–10. https://doi.org/10.1155/2020/7942549
    • Chicago/Turabian: Author-Date:
      Rauf, Abdur, Tareq Abu-Izneid, Umer Rashid, Fahad A. Alhumaydhi, Saud Bawazeer, Anees Ahmed Khalil, Abdullah S. M. Aljohani, et al. 2020. “Anti-Inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros Lotus.” BioMed Research International, June, 1–10. doi:10.1155/2020/7942549.
    • Harvard:
      Rauf, A. et al. (2020) ‘Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus’, BioMed Research International, pp. 1–10. doi: 10.1155/2020/7942549.
    • Harvard: Australian:
      Rauf, A, Abu-Izneid, T, Rashid, U, Alhumaydhi, FA, Bawazeer, S, Khalil, AA, Aljohani, ASM, Abdallah, EM, Al-Tawaha, AR, Mabkhot, YN, Shariati, MA, Plygun, S, Uddin, MS & Ntsefong, GN 2020, ‘Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus’, BioMed Research International, pp. 1–10, viewed 15 August 2020, .
    • MLA:
      Rauf, Abdur, et al. “Anti-Inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros Lotus.” BioMed Research International, June 2020, pp. 1–10. EBSCOhost, doi:10.1155/2020/7942549.
    • Chicago/Turabian: Humanities:
      Rauf, Abdur, Tareq Abu-Izneid, Umer Rashid, Fahad A. Alhumaydhi, Saud Bawazeer, Anees Ahmed Khalil, Abdullah S. M. Aljohani, et al. “Anti-Inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros Lotus.” BioMed Research International, June 7, 2020, 1–10. doi:10.1155/2020/7942549.
    • Vancouver/ICMJE:
      Rauf A, Abu-Izneid T, Rashid U, Alhumaydhi FA, Bawazeer S, Khalil AA, et al. Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus. BioMed Research International [Internet]. 2020 Jun 7 [cited 2020 Aug 15];1–10. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143635481