Pluchea indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice.

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  • Additional Information
    • Affiliation:
      School of Preclinic, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhon Ratchasima 30000, Thailand
      School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, UK
      Institute of Medicine, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhon Ratchasima 30000, Thailand
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Pluchea indica (L.) Less. (P. indica) tea has been used for a health-promoting drink, especially in Southeast Asia. The effect of P. indica tea (PIT) on amelioration of hyperglycemia; dyslipidemia that was total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and triglyceride (TG); and obesity in high fat diet-induced (HFD) mice was investigated. Oral glucose tolerance test (OGTT) displayed that PIT at 400 and 600 mg/kg orally ameliorated hyperglycemia with a dose-dependent manner compared to the untreated group. Moreover, PIT at these dosages exhibited significantly lower TC, LDL-C, TG, and perigonadal fat weight in HFD treated mice compared to HFD mice (P < 0.05) with a dose-dependent manner. In contrast, HDL-C was higher than in the HFD group, but not a significant difference (P > 0.05). The PIT chemical analysis results demonstrated that PIT contained total phenolic content (TPC), total flavonoid content (TFC), 4-O-caffeoylquinic acid (4-CQ), 5-O-caffeoylquinic acid (5-CQ), 3,4-O-dicaffeoylquinic acid (3,4-CQ), 3,5-O-dicaffeoylquinic acid (3,5-CQ), 4,5-O-dicaffeoylquinic acid (4,5-CQ), beta-caryophyllene, and gamma-gurjunene that may play an important role in inhibiting hyperlipidemia and hyperglycemia. Also, histological analysis expressed that the mean area and amount of perigonadal fat adipocytes of PIT treated groups were significantly lower and higher than the HFD group (P < 0.05), respectively. The toxicity test of PIT at 600 mg/kg/day in mice showed that serum creatinine, alanine transaminase (ALT), alkaline phosphatase (ALP), and complete blood count (CBC) levels of HFD and PIT treated groups were not significantly different compared to the normal control diet group (NCD) (P > 0.05). These results suggest that PIT does not become toxic to the kidney, liver, and blood. In conclusion, PIT has the potential to develop into healthy food supplement or medicine for the prevention and treatment of hyperglycemic, hyperlipidemic, and obese patients.
    • Journal Subset:
      Alternative/Complementary Therapies; Biomedical; Europe; Peer Reviewed; UK & Ireland
    • ISSN:
      1741-427X
    • MEDLINE Info:
      NLM UID: 101215021
    • Publication Date:
      20200606
    • Publication Date:
      20200609
    • DOI:
      10.1155/2020/8746137
    • Accession Number:
      143577855
  • Citations
    • ABNT:
      SIRICHAIWETCHAKOON, K. et al. Pluchea indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice. Evidence-based Complementary & Alternative Medicine (eCAM), [s. l.], p. 1–12, 2020. DOI 10.1155/2020/8746137. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143577855. Acesso em: 29 out. 2020.
    • AMA:
      Sirichaiwetchakoon K, Lowe GM, Kupittayanant S, Churproong S, Eumkeb G. Pluchea indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice. Evidence-based Complementary & Alternative Medicine (eCAM). June 2020:1-12. doi:10.1155/2020/8746137
    • APA:
      Sirichaiwetchakoon, K., Lowe, G. M., Kupittayanant, S., Churproong, S., & Eumkeb, G. (2020). Pluchea indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice. Evidence-Based Complementary & Alternative Medicine (ECAM), 1–12. https://doi.org/10.1155/2020/8746137
    • Chicago/Turabian: Author-Date:
      Sirichaiwetchakoon, Kittipot, Gordon Matthew Lowe, Sajeera Kupittayanant, Seekaow Churproong, and Griangsak Eumkeb. 2020. “Pluchea Indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice.” Evidence-Based Complementary & Alternative Medicine (ECAM), June, 1–12. doi:10.1155/2020/8746137.
    • Harvard:
      Sirichaiwetchakoon, K. et al. (2020) ‘Pluchea indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice’, Evidence-based Complementary & Alternative Medicine (eCAM), pp. 1–12. doi: 10.1155/2020/8746137.
    • Harvard: Australian:
      Sirichaiwetchakoon, K, Lowe, GM, Kupittayanant, S, Churproong, S & Eumkeb, G 2020, ‘Pluchea indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice’, Evidence-based Complementary & Alternative Medicine (eCAM), pp. 1–12, viewed 29 October 2020, .
    • MLA:
      Sirichaiwetchakoon, Kittipot, et al. “Pluchea Indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice.” Evidence-Based Complementary & Alternative Medicine (ECAM), June 2020, pp. 1–12. EBSCOhost, doi:10.1155/2020/8746137.
    • Chicago/Turabian: Humanities:
      Sirichaiwetchakoon, Kittipot, Gordon Matthew Lowe, Sajeera Kupittayanant, Seekaow Churproong, and Griangsak Eumkeb. “Pluchea Indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice.” Evidence-Based Complementary & Alternative Medicine (ECAM), June 3, 2020, 1–12. doi:10.1155/2020/8746137.
    • Vancouver/ICMJE:
      Sirichaiwetchakoon K, Lowe GM, Kupittayanant S, Churproong S, Eumkeb G. Pluchea indica (L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice. Evidence-based Complementary & Alternative Medicine (eCAM) [Internet]. 2020 Jun 3 [cited 2020 Oct 29];1–12. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143577855