Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch.

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  • Additional Information
    • Affiliation:
      Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
      Institute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan
      Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus 22060, Pakistan
      Institute of Fundamental Medicine and Biology, Department of Genetics, Kazan Federal University, 420008 Kazan, Russia
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      The objective of this study was to authenticate the ethnobotanical claims of the Nepeta ruderalis Buch.-Ham. (N. ruderalis) extract in the traditional system of medicine. Crude extract was prepared via a simple maceration process. DPPH free radical scavenging and carrageenan-induced rat paw edema models were used to monitor antioxidant and anti-inflammatory responses of the N. ruderalis extract. Furthermore, it was tested for antiplatelet aggregation, cardioprotective, and calcium channel antagonistic activities via standard documented protocols. The N. ruderalis extract exhibited 80.82% antioxidant activity (I C 50 = 207.51 ± 4.36 μ g) while the anti-inflammatory response was significant (p < 0.05 to p < 0.01) at 50 mg/kg (45.58%) and 100 mg/kg (60.90%) doses. Moreover, it was found to inhibit platelet aggregation (I C 50 = 1.06 and 0.91 mg/mL) and, in addition, to increase the force of contraction at the concentration of 3.0-10 mg/mL with a decrease in the heart rate on isolated paired atria (E C 50 = 11.78 mg / mL). Relaxant activity was observed on the isolated rabbit jejunum (E C 50 = 0.96 mg / mL) and trachea (E C 50 = 0.89 mg / mL). However, in a cumulative way, an 80-millimolar potassium-induced contraction was evaluated (E C 50 = 1.31 mg / mL). The N. ruderalis extract exhibited antioxidant, anti-inflammatory, platelet aggregating, cardiotonic, and calcium channel antagonistic activities, therefore proving scientifically its effectiveness in the traditional system of medicine.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200604
    • Publication Date:
      20200604
    • DOI:
      http://dx.doi.org/10.1155/2020/2096947
    • Accession Number:
      143523655
  • Citations
    • ABNT:
      ALEEM, A. et al. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International, [s. l.], p. 1–9, 2020. DOI 10.1155/2020/2096947. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143523655. Acesso em: 11 ago. 2020.
    • AMA:
      Aleem A, Janbaz KH, Imran I, et al. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International. June 2020:1-9. doi:10.1155/2020/2096947
    • APA:
      Aleem, A., Janbaz, K. H., Imran, I., Wahid, M., Bibi, S., Afzal, K., & Asad, M. H. H. B. (2020). Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International, 1–9. https://doi.org/10.1155/2020/2096947
    • Chicago/Turabian: Author-Date:
      Aleem, Ambreen, Khalid Hussain Janbaz, Imran Imran, Muqeet Wahid, Sumbal Bibi, Khurram Afzal, and Muhammad Hassham Hassan Bin Asad. 2020. “Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta Ruderalis Buch.” BioMed Research International, June, 1–9. doi:10.1155/2020/2096947.
    • Harvard:
      Aleem, A. et al. (2020) ‘Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch’, BioMed Research International, pp. 1–9. doi: 10.1155/2020/2096947.
    • Harvard: Australian:
      Aleem, A, Janbaz, KH, Imran, I, Wahid, M, Bibi, S, Afzal, K & Asad, MHHB 2020, ‘Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch’, BioMed Research International, pp. 1–9, viewed 11 August 2020, .
    • MLA:
      Aleem, Ambreen, et al. “Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta Ruderalis Buch.” BioMed Research International, June 2020, pp. 1–9. EBSCOhost, doi:10.1155/2020/2096947.
    • Chicago/Turabian: Humanities:
      Aleem, Ambreen, Khalid Hussain Janbaz, Imran Imran, Muqeet Wahid, Sumbal Bibi, Khurram Afzal, and Muhammad Hassham Hassan Bin Asad. “Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta Ruderalis Buch.” BioMed Research International, June 2020, 1–9. doi:10.1155/2020/2096947.
    • Vancouver/ICMJE:
      Aleem A, Janbaz KH, Imran I, Wahid M, Bibi S, Afzal K, et al. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International [Internet]. 2020 Jun [cited 2020 Aug 11];1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143523655