Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats.

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  • Additional Information
    • Affiliation:
      Department of Dynamic Sciences, Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
      Laboratory of Physiology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
      Laboratory of Biochemistry, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
      Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, Peru
      Department of Chemistry and Exact Sciences, Technical Particular University of Loja, Loja, Ecuador
      Instituto Regional de Enfermedades Neoplásicas, Trujillo, Peru
      Department of Physiology, Faculty of Medicine, Universidad Nacional de Trujillo, Trujillo, Peru
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      The objective of this study was to evaluate the chemopreventive effect of the ethanolic extract of Cordia lutea flowers (EECL) on N-methyl-N-nitrosourea- (MNU), cyproterone-, and testosterone-induced prostate cancer in rats. 40 Holtzman male rats were used and assigned to 5 groups (n = 8). In Group I, rats received normal saline (10 mL/Kg); Group II: rats were induced for prostate cancer with cyproterone, testosterone, and NMU; Groups III, IV, and V: rats received EECL daily, at doses of 50, 250, and 500 mg/kg body weight, respectively. After the period of treatment, animals were sacrificed by an overdose of pentobarbital and blood samples were collected for determination of prostate-specific antigen (PSA). The prostate was dissected and weighed accurately. The ventral lobe of the prostate was processed for histopathology analysis. The somatic prostate index decreased with EECL at dependent dose, from 0.34 ± 0.04 to 0.23 ± 0.05 (P < 0.05). The PSA levels also decreased significantly at doses of 250 and 500 mg/kg. Histopathological analysis showed a decrease in the number of prostatic layers with high-grade prostatic intraepithelial neoplasia (HG-PIN) and low-grade prostatic intraepithelial neoplasia (LG-PIN) at the dose of 500 mg/kg. The ethanolic extract of Cordia lutea flowers had a chemopreventive effect on induced prostate cancer in rats.
    • Journal Subset:
      Alternative/Complementary Therapies; Biomedical; Europe; Peer Reviewed; UK & Ireland
    • ISSN:
      1741-427X
    • MEDLINE Info:
      NLM UID: 101215021
    • Publication Date:
      20200529
    • Publication Date:
      20200601
    • DOI:
      http://dx.doi.org/10.1155/2020/5062942
    • Accession Number:
      143441800
  • Citations
    • ABNT:
      ROJAS-ARMAS, J. P. et al. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-based Complementary & Alternative Medicine (eCAM), [s. l.], p. 1–8, 2020. DOI 10.1155/2020/5062942. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143441800. Acesso em: 8 jul. 2020.
    • AMA:
      Rojas-Armas JP, Arroyo-Acevedo JL, Ortiz-Sánchez JM, et al. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-based Complementary & Alternative Medicine (eCAM). May 2020:1-8. doi:10.1155/2020/5062942.
    • AMA11:
      Rojas-Armas JP, Arroyo-Acevedo JL, Ortiz-Sánchez JM, et al. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-based Complementary & Alternative Medicine (eCAM). Published online May 26, 2020:1-8. doi:10.1155/2020/5062942
    • APA:
      Rojas-Armas, J. P., Arroyo-Acevedo, J. L., Ortiz-Sánchez, J. M., Palomino-Pacheco, M., Herrera-Calderón, O., Calva, J., Rojas-Armas, A., Justil-Guerrero, H. J., Castro-Luna, A., & Hilario-Vargas, J. (2020). Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-Based Complementary & Alternative Medicine (ECAM), 1–8. https://doi.org/10.1155/2020/5062942
    • Chicago/Turabian: Author-Date:
      Rojas-Armas, Juan Pedro, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, Miriam Palomino-Pacheco, Oscar Herrera-Calderón, James Calva, Agustín Rojas-Armas, Hugo Jesús Justil-Guerrero, Américo Castro-Luna, and Julio Hilario-Vargas. 2020. “Cordia Lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats.” Evidence-Based Complementary & Alternative Medicine (ECAM), May, 1–8. doi:10.1155/2020/5062942.
    • Harvard:
      Rojas-Armas, J. P. et al. (2020) ‘Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats’, Evidence-based Complementary & Alternative Medicine (eCAM), pp. 1–8. doi: 10.1155/2020/5062942.
    • Harvard: Australian:
      Rojas-Armas, JP, Arroyo-Acevedo, JL, Ortiz-Sánchez, JM, Palomino-Pacheco, M, Herrera-Calderón, O, Calva, J, Rojas-Armas, A, Justil-Guerrero, HJ, Castro-Luna, A & Hilario-Vargas, J 2020, ‘Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats’, Evidence-based Complementary & Alternative Medicine (eCAM), pp. 1–8, viewed 8 July 2020, .
    • MLA:
      Rojas-Armas, Juan Pedro, et al. “Cordia Lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats.” Evidence-Based Complementary & Alternative Medicine (ECAM), May 2020, pp. 1–8. EBSCOhost, doi:10.1155/2020/5062942.
    • Chicago/Turabian: Humanities:
      Rojas-Armas, Juan Pedro, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, Miriam Palomino-Pacheco, Oscar Herrera-Calderón, James Calva, Agustín Rojas-Armas, Hugo Jesús Justil-Guerrero, Américo Castro-Luna, and Julio Hilario-Vargas. “Cordia Lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats.” Evidence-Based Complementary & Alternative Medicine (ECAM), May 26, 2020, 1–8. doi:10.1155/2020/5062942.
    • Vancouver/ICMJE:
      Rojas-Armas JP, Arroyo-Acevedo JL, Ortiz-Sánchez JM, Palomino-Pacheco M, Herrera-Calderón O, Calva J, et al. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-based Complementary & Alternative Medicine (eCAM) [Internet]. 2020 May 26 [cited 2020 Jul 8];1–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143441800