Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals.

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  • Additional Information
    • Affiliation:
      Faculty of Veterinary and Animal Sciences, Department of Livestock Production, Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Pakistan
      Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China
      Department of Animal Health, Faculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture Peshawar, Pakistan
      Department of Animal Breeding and Genetics, Sindh Agriculture University, Tandojam, Pakistan
      Department of Forestry and Wildlife Management, The University of Haripur, Khyber Pakhtunkhwa, Pakistan
      Institute of Biological Sciences, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan
      Livestock and Dairy Development, Khyber Pakhtunkhwa, Pakistan
      Department of CMS (FVAS), Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Balochistan, Pakistan
      Adaptive Research Program, Quetta, Pakistan
      Guangdong Provincial Key Laboratory of Plant Molecular Breeding, Guangdong Subcenter of National Center for Soybean Improvement, College of Agriculture, South China Agricultural University, Guangzhou 510642, Guangdong, China
      Animal Science, School of Agriculture and Environment, Massey University, Palmerston North, New Zealand
      Key Laboratory of Henan Province for Drug Quality and Evaluation, Ministry of Education of China, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      The V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) gene is of the serine/threonine-protein kinase family and influences the production of milk fats and cholesterol by acting on the sterol administrative area restricting protein (SREBP). The AKT3 gene is highly preserved in animals, and during lactation in cattle, its expression increases. The AKT3 gene is expressed in the digestive system, mammary gland, and immune cells. A phylogenetic investigation was performed to clarify the evolutionary role of AKT3, by maximum probability. The AKT3 gene sequence data of various mammalian species was evident even with animals undergoing breeding selection. From 39 mammalian species studied, there was a signal of positive diversifying selection with Hominidae at 13Q, 16G, 23R, 24P, 121P, 294K, 327V, 376L, 397K, 445T, and 471F among other codon sites of the AKT3 gene. These sites were codes for amino acids such as arginine, proline, lysine, and leucine indicating major roles for the function of immunological proteins, and in particular, the study highlighted the importance of changes in gene expression of AKT3 on immunity.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200523
    • Publication Date:
      20200523
    • DOI:
      http://dx.doi.org/10.1155/2020/2584627
    • Accession Number:
      143347082
  • Citations
    • ABNT:
      FARMANULLAH et al. Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals. BioMed Research International, [s. l.], p. 1–13, 2020. DOI 10.1155/2020/2584627. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143347082. Acesso em: 13 ago. 2020.
    • AMA:
      Farmanullah, Hosseini SM, Liang A, et al. Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals. BioMed Research International. May 2020:1-13. doi:10.1155/2020/2584627
    • APA:
      Farmanullah, Hosseini, S. M., Liang, A., Hua, G., Rehman, Z. ur, Talpur, H. S., Salim, M., Ahmad, S., Abulaiti, A., Khan, M., Safdar, M., Kakar, I. U., Ahmad, Z., Ahmad, M. Z., Tingzhu, Y., Schreurs, N. M., Bano, I., & Yang, L. (2020). Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals. BioMed Research International, 1–13. https://doi.org/10.1155/2020/2584627
    • Chicago/Turabian: Author-Date:
      Farmanullah, Seyed Mahdi Hosseini, Aixin Liang, Guohua Hua, Zia ur Rehman, Hira Sajjad Talpur, Mohammad Salim, et al. 2020. “Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals.” BioMed Research International, May, 1–13. doi:10.1155/2020/2584627.
    • Harvard:
      Farmanullah et al. (2020) ‘Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals’, BioMed Research International, pp. 1–13. doi: 10.1155/2020/2584627.
    • Harvard: Australian:
      Farmanullah, Hosseini, SM, Liang, A, Hua, G, Rehman, Z ur, Talpur, HS, Salim, M, Ahmad, S, Abulaiti, A, Khan, M, Safdar, M, Kakar, IU, Ahmad, Z, Ahmad, MZ, Tingzhu, Y, Schreurs, NM, Bano, I & Yang, L 2020, ‘Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals’, BioMed Research International, pp. 1–13, viewed 13 August 2020, .
    • MLA:
      Farmanullah, et al. “Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals.” BioMed Research International, May 2020, pp. 1–13. EBSCOhost, doi:10.1155/2020/2584627.
    • Chicago/Turabian: Humanities:
      Farmanullah, Seyed Mahdi Hosseini, Aixin Liang, Guohua Hua, Zia ur Rehman, Hira Sajjad Talpur, Mohammad Salim, et al. “Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals.” BioMed Research International, May 20, 2020, 1–13. doi:10.1155/2020/2584627.
    • Vancouver/ICMJE:
      Farmanullah, Hosseini SM, Liang A, Hua G, Rehman Z ur, Talpur HS, et al. Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals. BioMed Research International [Internet]. 2020 May 20 [cited 2020 Aug 13];1–13. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143347082