Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila.

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  • Additional Information
    • Affiliation:
      Tangshan Key Laboratory of Traditional Chinese Medicine Pharmacology, College of Traditional Chinese Medicine, North China University of Science and Technology, 21 Bohai Road, Tangshan 063210, China
      School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China
      Department of Neuroscience, Scripps Research Institute, 130 Scripps Way Jupiter, Florida 33458, USA
      College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Xuefu Zhuyu Decoction (XFZYD), a Traditional Chinese Medicine (TCM) decoction mainly for treating blood stasis syndrome, has been widely investigated and applied in clinic and in laboratory. XFZYD contains 11 herbs and has been identified to promoting blood circulation to remove blood stasis for cardiovascular disease. Meanwhile, blood stasis is directly related to malignant tumor according to TCM basic theory. However, the effects of XFZYD on tumor metastasis and the underlying mechanisms are still largely unknown. Here, we employed well-established Drosophila cell migration and tumor invasion models to explore whether XFZYD has the anticancer activity on tumor metastasis in vivo. Our work has demonstrated that XFZYD could suppress cell migration and tumor invasion at the moderate concentrations. In addition, XFZYD altered the expression of MMP1, β-integrin, and E-cadherin to impede cell migration. Moreover, XFZYD inhibited ocular tumor invasion presumably by reducing the activity of Notch signaling. Together, these evidences reveal a positive role of XFZYD in suppressing cell migration and tumor metastasis, providing the potential drug targets and key clues for cancer clinical treatment strategies.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200512
    • Publication Date:
      20200514
    • DOI:
      10.1155/2020/5463652
    • Accession Number:
      143118691
  • Citations
    • ABNT:
      WANG, S. et al. Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila. BioMed Research International, [s. l.], p. 1–13, 2020. DOI 10.1155/2020/5463652. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143118691. Acesso em: 24 nov. 2020.
    • AMA:
      Wang S, Wu F, Ye B, et al. Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila. BioMed Research International. May 2020:1-13. doi:10.1155/2020/5463652
    • APA:
      Wang, S., Wu, F., Ye, B., Zhang, S., Wang, X., Xu, Q., Li, G., Zhang, M., Wang, S., Jia, Y., Jiang, C., La, X., Chang, H., Zhao, Z., Li, P., Li, J., & Wu, C. (2020). Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila. BioMed Research International, 1–13. https://doi.org/10.1155/2020/5463652
    • Chicago/Turabian: Author-Date:
      Wang, Sitong, Fanwu Wu, Bin Ye, Shiping Zhang, Xingjun Wang, Qian Xu, Guowang Li, et al. 2020. “Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila.” BioMed Research International, May, 1–13. doi:10.1155/2020/5463652.
    • Harvard:
      Wang, Sitong et al. (2020) ‘Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila’, BioMed Research International, pp. 1–13. doi: 10.1155/2020/5463652.
    • Harvard: Australian:
      Wang, Sitong, Wu, F, Ye, B, Zhang, S, Wang, X, Xu, Q, Li, G, Zhang, M, Wang, Shuai, Jia, Y, Jiang, C, La, X, Chang, H, Zhao, Z, Li, P, Li, J & Wu, C 2020, ‘Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila’, BioMed Research International, pp. 1–13, viewed 24 November 2020, .
    • MLA:
      Wang, Sitong, et al. “Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila.” BioMed Research International, May 2020, pp. 1–13. EBSCOhost, doi:10.1155/2020/5463652.
    • Chicago/Turabian: Humanities:
      Wang, Sitong, Fanwu Wu, Bin Ye, Shiping Zhang, Xingjun Wang, Qian Xu, Guowang Li, et al. “Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila.” BioMed Research International, May 8, 2020, 1–13. doi:10.1155/2020/5463652.
    • Vancouver/ICMJE:
      Wang S, Wu F, Ye B, Zhang S, Wang X, Xu Q, et al. Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila. BioMed Research International [Internet]. 2020 May 8 [cited 2020 Nov 24];1–13. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=143118691