Latent infection, inflammatory markers and suicide attempt history in depressive disorders.

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  • Additional Information
    • Affiliation:
      Psychiatry Research, University of Iowa Carver College of Medicine, 500 Newton Road, 2-205 MEB, Iowa City, IA, 52242-1000, USA
      Johns Hopkins University, USA
      University of Michigan, USA
      University of Illinois at Chicago, USA
      Stanley Division of Developmental Neurovirology, USA
    • Abstract:
      Background: Numerous reports have described increased rates of exposure to Toxoplasma gondii levels in individuals with a history of suicide attempts in comparison with well controls, or psychiatrically ill individuals, with no suicide attempt history. Such findings suggest that the behavioral effects this parasite exerts on rodent hosts extends to humans though few studies have searched for underlying mechanisms.Methods: The present study compared 96 patients with an active depressive disorder and a history of at least two suicide attempts to 126 depressed patients with no history of suicide attempts by IgG and IgM levels of Toxoplasma gondii and cytomegalovirus (CMV). The groups were also compared by IL_1b, TNF-alpha, CRP, IL_6, and IL_1ra titers.Results: Toxoplasma gondii IgM levels were higher, and seropositivity more likely, in the suicide attempt group. CMV IgG levels were also higher among suicide attempters. Several of these immunoglobulin measures were more robustly associated with the number of suicide attempts than with the dichotomy of suicide attempter and non-attempter. These two antibody levels were also additive in their association with suicide attempter status. IL_1a levels were lower in suicide attempters and correlated negatively with levels of antibodies to Toxoplasma gondii and CMV.Limitations: These include a sample size insufficient to explore differences across mood disorder diagnoses or demographic groupings.Conclusions: These results indicate that exposure to common infectious agents such as Toxoplasma gondii and CMV are associated with increased risk of suicide attempts but the mechanism of association does not appear to involve the activation of cytokines. Elucidation of the mechanisms which define the relationship between infections and suicide attempts may lead to new methods for the prediction and prevention of suicide attempts.
    • Journal Subset:
      Biomedical; Blind Peer Reviewed; Continental Europe; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed
    • ISSN:
      0165-0327
    • MEDLINE Info:
      PMID: NLM32339111 NLM UID: 7906073
    • Publication Date:
      In Process
    • Publication Date:
      20200429
    • DOI:
      10.1016/j.jad.2020.03.057
    • Accession Number:
      142888317
  • Citations
    • ABNT:
      CORYELL, W. et al. Latent infection, inflammatory markers and suicide attempt history in depressive disorders. Journal of Affective Disorders, [s. l.], v. 270, p. 97–101, 2020. DOI 10.1016/j.jad.2020.03.057. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=142888317. Acesso em: 30 set. 2020.
    • AMA:
      Coryell W, Wilcox H, Evans SJ, et al. Latent infection, inflammatory markers and suicide attempt history in depressive disorders. Journal of Affective Disorders. 2020;270:97-101. doi:10.1016/j.jad.2020.03.057
    • APA:
      Coryell, W., Wilcox, H., Evans, S. J., Pandey, G. N., Jones-Brando, L., Dickerson, F., & Yolken, R. (2020). Latent infection, inflammatory markers and suicide attempt history in depressive disorders. Journal of Affective Disorders, 270, 97–101. https://doi.org/10.1016/j.jad.2020.03.057
    • Chicago/Turabian: Author-Date:
      Coryell, William, Holly Wilcox, Simon J Evans, Ghanshyam N. Pandey, Lorraine Jones-Brando, Faith Dickerson, and Robert Yolken. 2020. “Latent Infection, Inflammatory Markers and Suicide Attempt History in Depressive Disorders.” Journal of Affective Disorders 270 (June): 97–101. doi:10.1016/j.jad.2020.03.057.
    • Harvard:
      Coryell, W. et al. (2020) ‘Latent infection, inflammatory markers and suicide attempt history in depressive disorders’, Journal of Affective Disorders, 270, pp. 97–101. doi: 10.1016/j.jad.2020.03.057.
    • Harvard: Australian:
      Coryell, W, Wilcox, H, Evans, SJ, Pandey, GN, Jones-Brando, L, Dickerson, F & Yolken, R 2020, ‘Latent infection, inflammatory markers and suicide attempt history in depressive disorders’, Journal of Affective Disorders, vol. 270, pp. 97–101, viewed 30 September 2020, .
    • MLA:
      Coryell, William, et al. “Latent Infection, Inflammatory Markers and Suicide Attempt History in Depressive Disorders.” Journal of Affective Disorders, vol. 270, June 2020, pp. 97–101. EBSCOhost, doi:10.1016/j.jad.2020.03.057.
    • Chicago/Turabian: Humanities:
      Coryell, William, Holly Wilcox, Simon J Evans, Ghanshyam N. Pandey, Lorraine Jones-Brando, Faith Dickerson, and Robert Yolken. “Latent Infection, Inflammatory Markers and Suicide Attempt History in Depressive Disorders.” Journal of Affective Disorders 270 (June 2020): 97–101. doi:10.1016/j.jad.2020.03.057.
    • Vancouver/ICMJE:
      Coryell W, Wilcox H, Evans SJ, Pandey GN, Jones-Brando L, Dickerson F, et al. Latent infection, inflammatory markers and suicide attempt history in depressive disorders. Journal of Affective Disorders [Internet]. 2020 Jun [cited 2020 Sep 30];270:97–101. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=142888317