Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults.

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  • Additional Information
    • Affiliation:
      Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago Illinois
      Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada
      Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois
    • Abstract:
      Chronic use of methamphetamine impairs frontostriatal structure and function, which may result in increased incentive-motivational responses to drug cues and decreased regulation of drug-seeking behavior. However, less is known regarding how the drug affects these circuits after acute administration. The current study examined the effects of a single dose of methamphetamine on resting state frontostriatal functional connectivity in healthy volunteers. Participants (n = 22, 12 female) completed two sessions in which they received methamphetamine (20 mg) and placebo before a resting state scan during functional magnetic resonance imaging. Participants also provided self-report measures of euphoria and stimulation at regular intervals. We conducted seed-based voxelwise functional connectivity analyses using three bilateral striatal seed regions: nucleus accumbens (NAcc), caudate, and putamen and compared connectivity following methamphetamine versus placebo administration. Additionally, we conducted correlational analyses to assess if drug-induced changes in functional connectivity were related to changes in subjective response. Methamphetamine increased NAcc functional connectivity with medial frontal regions (ie, orbitofrontal cortex, medial frontal gyrus, and superior frontal gyrus) and decreased NAcc functional connectivity with subgenual anterior cingulate cortex (ACC). Methamphetamine also increased functional connectivity between putamen and left inferior frontal gyrus (IFG), and individuals who displayed greater drug-induced increase in connectivity reported less euphoria and stimulation. These findings provide important information regarding the effects of methamphetamine on brain function in nonaddicted individuals. Further studies will reveal whether such effects contribute to the abuse potential of the drug and whether they are related to the frontostriatal impairments observed after chronic methamphetamine use.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      1355-6215
    • MEDLINE Info:
      PMID: NLM31099141 NLM UID: 9604935
    • Grant Information:
      R01 DA037011//National Institute on Drug Abuse/; S10 OD018448/OD/NIH HHS/United States; R01 DA037011/DA/NIDA NIH HHS/United States; T32MH020065/MH/NIMH NIH HHS/United States; K01 AA024519/AA/NIAAA NIH HHS/United States; T32 MH020065/MH/NIMH NIH HHS/United States; K01 AA024519//National Institute on Alcohol Abuse and Alcoholism/
    • Publication Date:
      In Process
    • Publication Date:
      20200428
    • DOI:
      http://dx.doi.org/10.1111/adb.12775
    • Accession Number:
      142767775
  • Citations
    • ABNT:
      WEAFER, J. et al. Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults. Addiction Biology, [s. l.], v. 25, n. 3, p. 1–9, 2020. DOI 10.1111/adb.12775. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=142767775. Acesso em: 10 ago. 2020.
    • AMA:
      Weafer J, Van Hedger K, Keedy SK, Nwaokolo N, Wit H, de Wit H. Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults. Addiction Biology. 2020;25(3):1-9. doi:10.1111/adb.12775
    • APA:
      Weafer, J., Van Hedger, K., Keedy, S. K., Nwaokolo, N., Wit, H., & de Wit, H. (2020). Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults. Addiction Biology, 25(3), 1–9. https://doi.org/10.1111/adb.12775
    • Chicago/Turabian: Author-Date:
      Weafer, Jessica, Kathryne Van Hedger, Sarah K. Keedy, Nkemdilim Nwaokolo, Harriet Wit, and Harriet de Wit. 2020. “Methamphetamine Acutely Alters Frontostriatal Resting State Functional Connectivity in Healthy Young Adults.” Addiction Biology 25 (3): 1–9. doi:10.1111/adb.12775.
    • Harvard:
      Weafer, J. et al. (2020) ‘Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults’, Addiction Biology, 25(3), pp. 1–9. doi: 10.1111/adb.12775.
    • Harvard: Australian:
      Weafer, J, Van Hedger, K, Keedy, SK, Nwaokolo, N, Wit, H & de Wit, H 2020, ‘Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults’, Addiction Biology, vol. 25, no. 3, pp. 1–9, viewed 10 August 2020, .
    • MLA:
      Weafer, Jessica, et al. “Methamphetamine Acutely Alters Frontostriatal Resting State Functional Connectivity in Healthy Young Adults.” Addiction Biology, vol. 25, no. 3, May 2020, pp. 1–9. EBSCOhost, doi:10.1111/adb.12775.
    • Chicago/Turabian: Humanities:
      Weafer, Jessica, Kathryne Van Hedger, Sarah K. Keedy, Nkemdilim Nwaokolo, Harriet Wit, and Harriet de Wit. “Methamphetamine Acutely Alters Frontostriatal Resting State Functional Connectivity in Healthy Young Adults.” Addiction Biology 25, no. 3 (May 2020): 1–9. doi:10.1111/adb.12775.
    • Vancouver/ICMJE:
      Weafer J, Van Hedger K, Keedy SK, Nwaokolo N, Wit H, de Wit H. Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults. Addiction Biology [Internet]. 2020 May [cited 2020 Aug 10];25(3):1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=142767775