Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Affiliation:
      Centro de Ciências da Saúde, Departamento de Neuropsiquiatria, Universidade Federal de Santa Maria, RS, Brazil
      Centro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, RS, Brazil
      Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
      Centro de Educação Física e Desportos, Laboratório de Bioquímica do Exercício (BIOEX), Universidade Federal de Santa Maria, RS, Brazil
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      The MnSOD Ala16Val single nucleotide polymorphism (SNP) has been associated with different diseases. However, there are scarcely studies relating this SNP in epilepsy, a neurologic disease that involves some interacting pathways, such as apoptotic and inflammatory factors. In this sense, we decided to investigate the relationship of MnSOD Ala16Val SNP with apoptotic markers in epilepsy and its relation with inflammatory pathway and seizure type. Ninety subjects were evaluated (47 epilepsies; 43 controls) by questionnaires and laboratorial exams. We observed a higher percentage of VV genotype in the epilepsy group when compared to the control group. IL-1β, IL-6, caspase-1, and caspase-3 levels were increased in the epilepsy group (VV genotype). Furthermore, an important correlation between IL-1β vs. caspase-1 and IL-6 vs. caspase-3 was observed in the epilepsy group (VV genotype). The epilepsy group which presented generalized seizures also demonstrated a positive correlation between IL-1β vs. CASP1 and IL-6 vs. CASP3. Thus, it is a plausible propose that epilepsy patients with VV genotype and generalized seizures present a worse inflammatory and apoptotic status. Our findings suggest that the knowledge of MnSOD Ala16Val polymorphism existence is important to evaluate molecular mechanisms associated to seizure and improve the treatment of these patients.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      2314-6133
    • MEDLINE Info:
      NLM UID: 101600173
    • Publication Date:
      20200318
    • Publication Date:
      20200318
    • DOI:
      http://dx.doi.org/10.1155/2020/6250429
    • Accession Number:
      142252600
  • Citations
    • ABNT:
      KEGLER, A. et al. Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways. BioMed Research International, [s. l.], p. 1–9, 2020. DOI 10.1155/2020/6250429. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=142252600. Acesso em: 10 ago. 2020.
    • AMA:
      Kegler A, Caprara ALF, Pascotini ET, et al. Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways. BioMed Research International. March 2020:1-9. doi:10.1155/2020/6250429
    • APA:
      Kegler, A., Caprara, A. L. F., Pascotini, E. T., Arend, J., Gabbi, P., Duarte, M. M. M. F., Furian, A. F., Oliveira, M. S., Royes, L. F. F., & Fighera, M. R. (2020). Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways. BioMed Research International, 1–9. https://doi.org/10.1155/2020/6250429
    • Chicago/Turabian: Author-Date:
      Kegler, Aline, Ana Letícia Fornari Caprara, Eduardo Tanuri Pascotini, Josi Arend, Patricia Gabbi, Marta M. M. F. Duarte, Ana Flavia Furian, Mauro Schneider Oliveira, Luiz Fernando Freire Royes, and Michele Rechia Fighera. 2020. “Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways.” BioMed Research International, March, 1–9. doi:10.1155/2020/6250429.
    • Harvard:
      Kegler, A. et al. (2020) ‘Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways’, BioMed Research International, pp. 1–9. doi: 10.1155/2020/6250429.
    • Harvard: Australian:
      Kegler, A, Caprara, ALF, Pascotini, ET, Arend, J, Gabbi, P, Duarte, MMMF, Furian, AF, Oliveira, MS, Royes, LFF & Fighera, MR 2020, ‘Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways’, BioMed Research International, pp. 1–9, viewed 10 August 2020, .
    • MLA:
      Kegler, Aline, et al. “Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways.” BioMed Research International, Mar. 2020, pp. 1–9. EBSCOhost, doi:10.1155/2020/6250429.
    • Chicago/Turabian: Humanities:
      Kegler, Aline, Ana Letícia Fornari Caprara, Eduardo Tanuri Pascotini, Josi Arend, Patricia Gabbi, Marta M. M. F. Duarte, Ana Flavia Furian, Mauro Schneider Oliveira, Luiz Fernando Freire Royes, and Michele Rechia Fighera. “Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways.” BioMed Research International, March 6, 2020, 1–9. doi:10.1155/2020/6250429.
    • Vancouver/ICMJE:
      Kegler A, Caprara ALF, Pascotini ET, Arend J, Gabbi P, Duarte MMMF, et al. Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways. BioMed Research International [Internet]. 2020 Mar 6 [cited 2020 Aug 10];1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=142252600