Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review.

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  • Additional Information
    • Affiliation:
      Division of Infectious Diseases, Departments of Pediatrics, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence
      Division of Rheumatology, Department of Pediatrics, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence
      Division of Infectious Diseases, Departments of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence
      Division of Infectious Diseases, Departments of Pathology and Laboratory Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Cryptococcus albidus , synonymous with Naganishia albida, rarely causes opportunistic infection in immunocompromised individuals. Its clinical features, particularly in children, are not well defined. Here, we report a case of C albidus fungemia in an immunosuppressed child; we also present results of a systematic review, for which we searched PubMed, Embase, and Web of Science using the keywords "cryptococcus" and "albidus." Our goal was to describe the spectrum of disease, diagnostic approaches, therapies, and outcomes. We identified 20 cases of invasive infection, only 2 of which involved children, and 7 cases of noninvasive infection. The reports originated in the Americas, Europe, and Asia. Of those with invasive infection, 16 (80%) patients had an underlying chronic disorder or had received immunosuppressive therapy, 8 (40%) had fungemia, and 6 (30%) had a central nervous system infection. The attributable case fatality rate was 40%. C albidus is an opportunistic yeast that can rarely cause life-threatening fungemia and central nervous system infection in individuals of any age, especially those who are immunocompromised.
    • Journal Subset:
      Biomedical
    • Special Interest:
      Evidence-Based Practice
    • ISSN:
      2048-7193
    • Publication Date:
      20200311
    • Publication Date:
      20200708
    • DOI:
      http://dx.doi.org/10.1093/jpids/piz039
    • Accession Number:
      142126406
  • Citations
    • ABNT:
      CHOE, Y. J. et al. Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review. Journal of the Pediatric Infectious Diseases Society, [s. l.], v. 9, n. 1, p. 100–105, 2020. DOI 10.1093/jpids/piz039. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=142126406. Acesso em: 7 ago. 2020.
    • AMA:
      Choe YJ, Blatt DB, Yalcindag A, Geffert SF, Bobenchik AM, Michelow IC. Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review. Journal of the Pediatric Infectious Diseases Society. 2020;9(1):100-105. doi:10.1093/jpids/piz039
    • APA:
      Choe, Y. J., Blatt, D. B., Yalcindag, A., Geffert, S. F., Bobenchik, A. M., & Michelow, I. C. (2020). Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review. Journal of the Pediatric Infectious Diseases Society, 9(1), 100–105. https://doi.org/10.1093/jpids/piz039
    • Chicago/Turabian: Author-Date:
      Choe, Young June, Daniel B Blatt, Ali Yalcindag, Sara F Geffert, April M Bobenchik, and Ian C Michelow. 2020. “Cryptococcus Albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review.” Journal of the Pediatric Infectious Diseases Society 9 (1): 100–105. doi:10.1093/jpids/piz039.
    • Harvard:
      Choe, Y. J. et al. (2020) ‘Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review’, Journal of the Pediatric Infectious Diseases Society, 9(1), pp. 100–105. doi: 10.1093/jpids/piz039.
    • Harvard: Australian:
      Choe, YJ, Blatt, DB, Yalcindag, A, Geffert, SF, Bobenchik, AM & Michelow, IC 2020, ‘Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review’, Journal of the Pediatric Infectious Diseases Society, vol. 9, no. 1, pp. 100–105, viewed 7 August 2020, .
    • MLA:
      Choe, Young June, et al. “Cryptococcus Albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review.” Journal of the Pediatric Infectious Diseases Society, vol. 9, no. 1, Mar. 2020, pp. 100–105. EBSCOhost, doi:10.1093/jpids/piz039.
    • Chicago/Turabian: Humanities:
      Choe, Young June, Daniel B Blatt, Ali Yalcindag, Sara F Geffert, April M Bobenchik, and Ian C Michelow. “Cryptococcus Albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review.” Journal of the Pediatric Infectious Diseases Society 9, no. 1 (March 2020): 100–105. doi:10.1093/jpids/piz039.
    • Vancouver/ICMJE:
      Choe YJ, Blatt DB, Yalcindag A, Geffert SF, Bobenchik AM, Michelow IC. Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review. Journal of the Pediatric Infectious Diseases Society [Internet]. 2020 Mar [cited 2020 Aug 7];9(1):100–5. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=142126406