Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings.

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  • Additional Information
    • Affiliation:
      Vitalant, Pittsburgh, Pennsylvania
      Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania
      Department of Pediatrics, Division of Critical Care Medicine, Washington University in St Louis, St Louis, Missouri
      Department of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, Ontario, Canada
      Canadian Field Hospital, Canadian Armed Forces, Ottawa, Ontario, Canada
      Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts
      Wing-Kwai and Alice Lee-Tsing Chung Transfusion Service, Department of Pathology and Laboratory Medicine, UCLA Health, Los Angeles, California
      Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington
      Hemorio, Rio de Janeiro, Brazil
      Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland
      Institute of Transfusion Medicine, University of Cologne, University Hospital, Cologne, Germany
      Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia
      Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina
      Department of Pathology, University of New Mexico, Albuquerque, New Mexico
      Vancouver Coastal Health Authority, Vancouver, British Columbia, Canada
      Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
      Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
      Departments of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
      National Health Service Blood and Transplant, and Oxford Biomedical Research Centre, Oxford, United Kingdom
    • Corporate Authors:
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background: Group O erythrocytes and/or whole blood are used for urgent transfusions in patients of unknown blood type. This study investigated the impact of transfusing increasing numbers of uncrossmatched type O products on the recipient's first in-hospital ABO type.Methods: This was a retrospective cohort study. Results of the first ABO type obtained in adult, non-type O recipients (i.e., types A, B, AB) after receiving at least one unit of uncrossmatched type O erythrocyte-containing product(s) for any bleeding etiology were analyzed along with the number of uncrossmatched type O erythrocyte-containing products administered in the prehospital and/or in hospital setting before the first type and screen sample was drawn.Results: There were 10 institutions that contributed a total of 695 patient records. Among patients who received up to 10 uncrossmatched type O erythrocyte-containing products, the median A antigen agglutination strength in A and AB individuals on forward typing (i.e., testing the recipient's erythrocytes for A and/or B antigens) was the maximum (4+), whereas the median B antigen agglutination strength among B and AB recipients of up to 10 units was 3 to 4+. The median agglutination strength on the reverse type (i.e., testing the recipient's plasma for corresponding anti-A and -B antibodies) was very strong, between 3 and 4+, for recipients of up to 10 units of uncrossmatched erythrocyte-containing products. Overall, the ABO type of 665 of 695 (95.7%; 95% CI, 93.9 to 97.0%) of these patients could be accurately determined on the first type and screen sample obtained after transfusion of uncrossmatched type O erythrocyte-containing products.Conclusions: The transfusion of smaller quantities of uncrossmatched type O erythrocyte-containing products, in particular up to 10 units, does not usually interfere with determining the recipient's ABO type. The early collection of a type and screen sample is important.
    • Journal Subset:
      Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA
    • Instrumentation:
      Screen for Caregiver Burden (SCB)
      Bleeding Index
      Impact of Events Scale (IES)
    • ISSN:
      0003-3022
    • MEDLINE Info:
      PMID: NLM31789634 NLM UID: 1300217
    • Publication Date:
      20200619
    • Publication Date:
      20200625
    • DOI:
      10.1097/ALN.0000000000003069
    • Accession Number:
      141891775
  • Citations
    • ABNT:
      YAZER, M. H. et al. Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings. Anesthesiology, [s. l.], v. 132, n. 3, p. 525–534, 2020. DOI 10.1097/ALN.0000000000003069. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=141891775. Acesso em: 25 set. 2020.
    • AMA:
      Yazer MH, Spinella PC, Doyle L, et al. Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings. Anesthesiology. 2020;132(3):525-534. doi:10.1097/ALN.0000000000003069
    • APA:
      Yazer, M. H., Spinella, P. C., Doyle, L., Kaufman, R. M., Dunn, R., Hess, J. R., Filho, L. A., Fontaine, M., Gathof, B., Jackson, B., Murphy, M. F., Pasion, J., Raval, J. S., Rosinski, K., Seheult, J., Shih, A. W., Sperry, J., Staves, J., Tuott, E. E., & Ziman, A. (2020). Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings. Anesthesiology, 132(3), 525–534. https://doi.org/10.1097/ALN.0000000000003069
    • Chicago/Turabian: Author-Date:
      Yazer, Mark H., Philip C. Spinella, Leilani Doyle, Richard M. Kaufman, Robyn Dunn, John R. Hess, Luiz Amorim Filho, et al. 2020. “Transfusion of Uncrossmatched Group O Erythrocyte-Containing Products Does Not Interfere with Most ABO Typings.” Anesthesiology 132 (3): 525–34. doi:10.1097/ALN.0000000000003069.
    • Harvard:
      Yazer, M. H. et al. (2020) ‘Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings’, Anesthesiology, 132(3), pp. 525–534. doi: 10.1097/ALN.0000000000003069.
    • Harvard: Australian:
      Yazer, MH, Spinella, PC, Doyle, L, Kaufman, RM, Dunn, R, Hess, JR, Filho, LA, Fontaine, M, Gathof, B, Jackson, B, Murphy, MF, Pasion, J, Raval, JS, Rosinski, K, Seheult, J, Shih, AW, Sperry, J, Staves, J, Tuott, EE & Ziman, A 2020, ‘Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings’, Anesthesiology, vol. 132, no. 3, pp. 525–534, viewed 25 September 2020, .
    • MLA:
      Yazer, Mark H., et al. “Transfusion of Uncrossmatched Group O Erythrocyte-Containing Products Does Not Interfere with Most ABO Typings.” Anesthesiology, vol. 132, no. 3, Mar. 2020, pp. 525–534. EBSCOhost, doi:10.1097/ALN.0000000000003069.
    • Chicago/Turabian: Humanities:
      Yazer, Mark H., Philip C. Spinella, Leilani Doyle, Richard M. Kaufman, Robyn Dunn, John R. Hess, Luiz Amorim Filho, et al. “Transfusion of Uncrossmatched Group O Erythrocyte-Containing Products Does Not Interfere with Most ABO Typings.” Anesthesiology 132, no. 3 (March 2020): 525–34. doi:10.1097/ALN.0000000000003069.
    • Vancouver/ICMJE:
      Yazer MH, Spinella PC, Doyle L, Kaufman RM, Dunn R, Hess JR, et al. Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings. Anesthesiology [Internet]. 2020 Mar [cited 2020 Sep 25];132(3):525–34. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=141891775