Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study.

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  • Additional Information
    • Affiliation:
      Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China
      Your Health & Wellness International Medical Clinic, Beijing, China
      Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
      Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, China
      Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
      Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
      Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Major depressive disorder (MDD), especially combined with anxiety, has a high incidence and low detection rate in China. Literature has shown that patients under major depression with anxiety (MDA) are more likely to nominate a somatic, rather than psychological, symptom as their presenting complaint. In the theory of Traditional Chinese Medicine (TCM), clinical symptoms of MDD patients are mainly categorized into two different syndrome patterns: Deficiency and Excess. We intend to use resting-state functional magnetic resonance imaging (rs-fMRI) to investigate their brain functional differences and hopefully to find their brain function mechanism. For our research, 42 drug-naive MDA patients were divided into two groups (21 for Deficiency and 21 for Excess), with an additional 19 unaffected participants in the normal control (NC) group. We took Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA), and brain fMRI scan for each group and analyzed the data. We first used Degree Centrality (DC) to map the functional differences in brain regions, utilized these regions as seed points, and used a seed-based functional connectivity (FC) analysis to identify the specific functional connection between groups. The Deficiency group was found to have higher HAMD scores, HAMA scores, and HAMD somatic factor than the Excess group. In the DC analysis, significant decreases were found in the right precuneus of both the Deficiency and Excess groups compared to the NC group. In the FC analysis, the right precuneus showed significant decreased network connectivity with the bilateral cuneus, as well as the right lingual gyrus in the Deficiency group when compared to the NC group and the Excess group. Through our research, it was found that precuneus dysfunction may have a relationship with MDA and Deficiency patients have more severe physical and emotional symptoms, and we realized that a larger sample size and multiple brain mode observations were needed in further research.
    • Journal Subset:
      Alternative/Complementary Therapies; Biomedical; Europe; Peer Reviewed; UK & Ireland
    • Instrumentation:
      Hamilton Rating Scale for Depression (HRSD)
      Hamilton Anxiety Rating Scale (HAM-A)
    • ISSN:
      1741-427X
    • MEDLINE Info:
      NLM UID: 101215021
    • Publication Date:
      20200225
    • Publication Date:
      20200302
    • DOI:
      http://dx.doi.org/10.1155/2020/7504917
    • Accession Number:
      141802669
  • Citations
    • ABNT:
      DU, Y. et al. Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study. Evidence-based Complementary & Alternative Medicine (eCAM), [s. l.], p. 1–9, 2020. DOI 10.1155/2020/7504917. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=141802669. Acesso em: 15 ago. 2020.
    • AMA:
      Du Y, Zhao J, Wang Y, et al. Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study. Evidence-based Complementary & Alternative Medicine (eCAM). February 2020:1-9. doi:10.1155/2020/7504917
    • APA:
      Du, Y., Zhao, J., Wang, Y., Han, Y., Deng, L., Jia, H., Zhou, Y., Su, J., & Li, L. (2020). Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study. Evidence-Based Complementary & Alternative Medicine (ECAM), 1–9. https://doi.org/10.1155/2020/7504917
    • Chicago/Turabian: Author-Date:
      Du, Yi, Jingjie Zhao, Yongzhi Wang, Yu Han, Ligang Deng, Hongxiao Jia, Yuan Zhou, Joyce Su, and Li Li. 2020. “Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State FMRI Study.” Evidence-Based Complementary & Alternative Medicine (ECAM), February, 1–9. doi:10.1155/2020/7504917.
    • Harvard:
      Du, Y. et al. (2020) ‘Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study’, Evidence-based Complementary & Alternative Medicine (eCAM), pp. 1–9. doi: 10.1155/2020/7504917.
    • Harvard: Australian:
      Du, Y, Zhao, J, Wang, Y, Han, Y, Deng, L, Jia, H, Zhou, Y, Su, J & Li, L 2020, ‘Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study’, Evidence-based Complementary & Alternative Medicine (eCAM), pp. 1–9, viewed 15 August 2020, .
    • MLA:
      Du, Yi, et al. “Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State FMRI Study.” Evidence-Based Complementary & Alternative Medicine (ECAM), Feb. 2020, pp. 1–9. EBSCOhost, doi:10.1155/2020/7504917.
    • Chicago/Turabian: Humanities:
      Du, Yi, Jingjie Zhao, Yongzhi Wang, Yu Han, Ligang Deng, Hongxiao Jia, Yuan Zhou, Joyce Su, and Li Li. “Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State FMRI Study.” Evidence-Based Complementary & Alternative Medicine (ECAM), February 18, 2020, 1–9. doi:10.1155/2020/7504917.
    • Vancouver/ICMJE:
      Du Y, Zhao J, Wang Y, Han Y, Deng L, Jia H, et al. Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study. Evidence-based Complementary & Alternative Medicine (eCAM) [Internet]. 2020 Feb 18 [cited 2020 Aug 15];1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=141802669