Novel Example of a Direct-Agglutinating Anti-Ku.

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  • Additional Information
    • Affiliation:
      Immunohematology Reference Laboratory—Orlando, Orlando, Florida
      Scientific Medical and Technical Administration, OneBlood, Inc, Orlando, Florida
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background Several Kell-system antibodies are known to cause direct agglutination. Also, some specificities, such as anti-Ku, have been reported to react only via the indirect antiglobulin test (IAT). Methods Herein, we describe the case of a 61-year-old alloimmunized white woman who presented to an outside hospital with a gastrointestinal (GI) bleed and a "possible anti-Ku" was reported with 3+ reactivity at PEG-IAT and at Ficin-IAT; in addition to an unidentified cold antibody. Subsequently, when the patient presented to a second outside hospital, an anti-Ku that caused 3+ to 4+ reactions at saline-immediate spin (IS) was identified. The reactivity was evaluated with 0.01-M dithiothreitol (DTT) treatment of the plasma. Results It was determined that the strong agglutination with saline-IS was caused by immunoglobulin (Ig)M anti-Ku. Conclusion To our knowledge, this is the first reported case of an IgM anti-Ku.
    • Journal Subset:
      Allied Health; Peer Reviewed; USA
    • ISSN:
      0007-5027
    • MEDLINE Info:
      NLM UID: 0250641
    • Publication Date:
      20200109
    • Publication Date:
      20200109
    • DOI:
      http://dx.doi.org/10.1093/labmed/lmz021
    • Accession Number:
      141054917
  • Citations
    • ABNT:
      GANNETT, M. S.; GAMMON, R. R. Novel Example of a Direct-Agglutinating Anti-Ku. Laboratory Medicine, [s. l.], v. 51, n. 1, p. 47–49, 2020. DOI 10.1093/labmed/lmz021. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=141054917. Acesso em: 2 jul. 2020.
    • AMA:
      Gannett MS, Gammon RR. Novel Example of a Direct-Agglutinating Anti-Ku. Laboratory Medicine. 2020;51(1):47-49. doi:10.1093/labmed/lmz021.
    • AMA11:
      Gannett MS, Gammon RR. Novel Example of a Direct-Agglutinating Anti-Ku. Laboratory Medicine. 2020;51(1):47-49. doi:10.1093/labmed/lmz021
    • APA:
      Gannett, M. S., & Gammon, R. R. (2020). Novel Example of a Direct-Agglutinating Anti-Ku. Laboratory Medicine, 51(1), 47–49. https://doi.org/10.1093/labmed/lmz021
    • Chicago/Turabian: Author-Date:
      Gannett, Michael Sel, and Richard R Gammon. 2020. “Novel Example of a Direct-Agglutinating Anti-Ku.” Laboratory Medicine 51 (1): 47–49. doi:10.1093/labmed/lmz021.
    • Harvard:
      Gannett, M. S. and Gammon, R. R. (2020) ‘Novel Example of a Direct-Agglutinating Anti-Ku’, Laboratory Medicine, 51(1), pp. 47–49. doi: 10.1093/labmed/lmz021.
    • Harvard: Australian:
      Gannett, MS & Gammon, RR 2020, ‘Novel Example of a Direct-Agglutinating Anti-Ku’, Laboratory Medicine, vol. 51, no. 1, pp. 47–49, viewed 2 July 2020, .
    • MLA:
      Gannett, Michael Sel, and Richard R. Gammon. “Novel Example of a Direct-Agglutinating Anti-Ku.” Laboratory Medicine, vol. 51, no. 1, Feb. 2020, pp. 47–49. EBSCOhost, doi:10.1093/labmed/lmz021.
    • Chicago/Turabian: Humanities:
      Gannett, Michael Sel, and Richard R Gammon. “Novel Example of a Direct-Agglutinating Anti-Ku.” Laboratory Medicine 51, no. 1 (February 2020): 47–49. doi:10.1093/labmed/lmz021.
    • Vancouver/ICMJE:
      Gannett MS, Gammon RR. Novel Example of a Direct-Agglutinating Anti-Ku. Laboratory Medicine [Internet]. 2020 Feb [cited 2020 Jul 2];51(1):47–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=141054917