Use and safety of riboflavin and UV light-treated platelet transfusions in children over a five-year period: focusing on neonates.

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  • Additional Information
    • Affiliation:
      Fundació Banc de Sang i Teixits de les Illes Balears, Majorca Spain
      Grupo de Investigación en Salud Pública de las Illes Balears, Institut d'Investigació Sanitària Illes Balears (IdISBa), Majorca Spain
      Hospital Universitari Son Espases, Majorca Spain
      Clinica y Biologia de las Neoplasias Hematologicas, Institut d'Investigació Sanitària Illes Balears (IdISBa), Majorca Spain
      Fundació Banc de Sang i Teixits de les Illes Balears, Majorca, Spain
      Grupo de Investigación en Salud Pública de las Illes Balears, Institut d'Investigació Sanitària Illes Balears (IdISBa), Majorca, Spain
      Hospital Universitari Son Espases, Majorca, Spain
      Clinica y Biologia de las Neoplasias Hematologicas, Institut d'Investigació Sanitària Illes Balears (IdISBa), Majorca, Spain
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background: There are very few published reports about the use and safety of pathogen reduction technology (PRT) based on riboflavin and UV light for platelet (PLT) transfusion in children.Study Design and Methods: A two-part study was conducted: 1) a study investigating the safety of PLTs treated with riboflavin and UV light-PRT transfused to 379 children and 1,980 adults over a 5-year period; 2) an observational study evaluating the efficacy of PLT use in 132 neonates transfused with PRT-treated PLT compared with 99 neonates receiving standard PLTs over two 5-year periods.Results: The rate of adverse reactions related to transfusions with PRT-treated PLTs was found to be slightly higher in adults than in children, although not statistically significant (0.19% vs. 0.12%; p = 0.85). All PLT transfusion events in children were mild. From 2013 to 2017, 379 children received 4,236 riboflavin and UV light-treated PLTs. Hemato-oncology patients received the most PLT transfusions (61.2%), followed by critically ill children in the Pediatric Intensive Care Unit (PICU) (24.6%), and neonates in the Neonatal Intensive Care Unit (NICU) (10.5%). A significant increase in PLT transfusions was found in 132 neonates transfused with 458 PRT-treated PLTs compared with 99 neonates receiving 176 standard PLTs, measuring PLT use/patient (p = 0.031) and total PLT dose/patient (p = 0.041).Conclusions: Riboflavin and UV light-based PRT for PLTs seems to be safe for children. Neonates required a higher number of PLT transfusions when these were PRT-treated rather than standard. A long-term follow-up for chronically transfused children and randomized clinical trials are needed.
    • Journal Subset:
      Allied Health; Biomedical; Peer Reviewed; USA
    • Instrumentation:
      Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins)
    • ISSN:
      0041-1132
    • MEDLINE Info:
      PMID: NLM31587287 NLM UID: 0417360
    • Publication Date:
      20200617
    • Publication Date:
      20200617
    • DOI:
      http://dx.doi.org/10.1111/trf.15538
    • Accession Number:
      140157024
  • Citations
    • ABNT:
      JIMENEZ, M. T. et al. Use and safety of riboflavin and UV light-treated platelet transfusions in children over a five-year period: focusing on neonates. Transfusion, [s. l.], v. 59, n. 12, p. 3580–3588, 2019. DOI 10.1111/trf.15538. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=140157024. Acesso em: 2 jul. 2020.
    • AMA:
      Jimenez MT, Garcia RM, Girona LE, Jimenez-Marco T, Garcia-Recio M, Girona-Llobera E. Use and safety of riboflavin and UV light-treated platelet transfusions in children over a five-year period: focusing on neonates. Transfusion. 2019;59(12):3580-3588. doi:10.1111/trf.15538.
    • AMA11:
      Jimenez MT, Garcia RM, Girona LE, Jimenez-Marco T, Garcia-Recio M, Girona-Llobera E. Use and safety of riboflavin and UV light-treated platelet transfusions in children over a five-year period: focusing on neonates. Transfusion. 2019;59(12):3580-3588. doi:10.1111/trf.15538
    • APA:
      Jimenez, M. T., Garcia, R. M., Girona, L. E., Jimenez-Marco, T., Garcia-Recio, M., & Girona-Llobera, E. (2019). Use and safety of riboflavin and UV light-treated platelet transfusions in children over a five-year period: focusing on neonates. Transfusion, 59(12), 3580–3588. https://doi.org/10.1111/trf.15538
    • Chicago/Turabian: Author-Date:
      Jimenez, Marco, Teresa, Recio, Marta Garcia, Llobera, Enrique Girona, Teresa Jimenez-Marco, Marta Garcia-Recio, and Enrique Girona-Llobera. 2019. “Use and Safety of Riboflavin and UV Light-Treated Platelet Transfusions in Children over a Five-Year Period: Focusing on Neonates.” Transfusion 59 (12): 3580–88. doi:10.1111/trf.15538.
    • Harvard:
      Jimenez, M. T. et al. (2019) ‘Use and safety of riboflavin and UV light-treated platelet transfusions in children over a five-year period: focusing on neonates’, Transfusion, 59(12), pp. 3580–3588. doi: 10.1111/trf.15538.
    • Harvard: Australian:
      Jimenez, MT, Garcia, RM, Girona, LE, Jimenez-Marco, T, Garcia-Recio, M & Girona-Llobera, E 2019, ‘Use and safety of riboflavin and UV light-treated platelet transfusions in children over a five-year period: focusing on neonates’, Transfusion, vol. 59, no. 12, pp. 3580–3588, viewed 2 July 2020, .
    • MLA:
      Jimenez, Marco, Teresa, et al. “Use and Safety of Riboflavin and UV Light-Treated Platelet Transfusions in Children over a Five-Year Period: Focusing on Neonates.” Transfusion, vol. 59, no. 12, Dec. 2019, pp. 3580–3588. EBSCOhost, doi:10.1111/trf.15538.
    • Chicago/Turabian: Humanities:
      Jimenez, Marco, Teresa, Recio, Marta Garcia, Llobera, Enrique Girona, Teresa Jimenez-Marco, Marta Garcia-Recio, and Enrique Girona-Llobera. “Use and Safety of Riboflavin and UV Light-Treated Platelet Transfusions in Children over a Five-Year Period: Focusing on Neonates.” Transfusion 59, no. 12 (December 2019): 3580–88. doi:10.1111/trf.15538.
    • Vancouver/ICMJE:
      Jimenez MT, Garcia RM, Girona LE, Jimenez-Marco T, Garcia-Recio M, Girona-Llobera E. Use and safety of riboflavin and UV light-treated platelet transfusions in children over a five-year period: focusing on neonates. Transfusion [Internet]. 2019 Dec [cited 2020 Jul 2];59(12):3580–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=140157024