A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue.

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  • Additional Information
    • Affiliation:
      Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, 1230 York Avenue, New York, NY, USA
      Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic
      Department of Orthopedics, Physical Medicine & Rehabilitation, University of Munich (LMU), Munich, Germany
      Department of Orthopedic Surgery, University Southern California, Los Angeles, CA, USA
      Northern Ireland Centre for Stratified Medicine, School of Biomedical Sciences, Ulster University, Londonderry, United Kingdom
      Department of Biomedicine, Aarhus University, Aarhus, Denmark
      Marian University Osteopathic Medical School, Indianapolis, IN, USA
      Department of Biological Sciences and Binghamton Biofilm Research Center, Binghamton University, Binghamton, NY, USA
      Department of Orthopedic Surgery, Spine Unit, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
      Department of Microbiology, Faculty of Medicine, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic
      Department of Pathology, Microbiology and Immunology, School of Medicine, Vanderbilt University, Nashville, TN, USA
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Purpose: Recent research shows an increasing recognition that organisms not traditionally considered infectious in nature contribute to disease processes. Propionibacterium acnes (P. acnes) is a gram-positive, aerotolerant anaerobe prevalent in the sebaceous gland-rich areas of the human skin. A ubiquitous slow-growing organism with the capacity to form biofilm, P. acnes, recognized for its role in acne vulgaris and medical device-related infections, is now also linked to a number of other human diseases. While bacterial culture and molecular techniques are used to investigate the involvement of P. acnes in such diseases, definitive demonstration of P. acnes infection requires a technique (or techniques) sensitive to the presence of biofilms and insensitive to the presence of potential contamination. Fortunately, there are imaging techniques meeting these criteria, in particular, fluorescence in situ hybridization and immunofluorescence coupled with confocal laser scanning microscopy, as well as immunohistochemistry.Methods: Our literature review considers a range of microscopy-based studies that provides definitive evidence of P. acnes colonization within tissue from a number of human diseases (acne vulgaris, degenerative disc and prostate disease and atherosclerosis), some of which are currently not considered to have an infectious etiology.Results/conclusion: We conclude that P. acnes is an opportunistic pathogen with a likely underestimated role in the development of various human diseases associated with significant morbidity and, in some cases, mortality. As such, these findings offer the potential for new studies aimed at understanding the pathological mechanisms driving the observed disease associations, as well as novel diagnostic strategies and treatment strategies, particularly for degenerative disc disease. These slides can be retrieved under Electronic Supplementary Material.
    • Journal Subset:
      Biomedical; Continental Europe; Europe; Peer Reviewed
    • Instrumentation:
      Diagnostic Interview Schedule for Children (DISC)
    • ISSN:
      0940-6719
    • MEDLINE Info:
      PMID: NLM31359216 NLM UID: 9301980
    • Publication Date:
      20200528
    • Publication Date:
      20201130
    • DOI:
      10.1007/s00586-019-06086-y
    • Accession Number:
      139827182
  • Citations
    • ABNT:
      CAPOOR, M. N. et al. A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue. European Spine Journal, [s. l.], v. 28, n. 12, p. 2951–2971, 2019. DOI 10.1007/s00586-019-06086-y. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=139827182. Acesso em: 5 dez. 2020.
    • AMA:
      Capoor MN, Birkenmaier C, Wang JC, et al. A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue. European Spine Journal. 2019;28(12):2951-2971. doi:10.1007/s00586-019-06086-y
    • APA:
      Capoor, M. N., Birkenmaier, C., Wang, J. C., McDowell, A., Ahmed, F. S., Brüggemann, H., Coscia, E., Davies, D. G., Ohrt-Nissen, S., Raz, A., Ruzicka, F., Schmitz, J. E., Fischetti, V. A., & Slaby, O. (2019). A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue. European Spine Journal, 28(12), 2951–2971. https://doi.org/10.1007/s00586-019-06086-y
    • Chicago/Turabian: Author-Date:
      Capoor, Manu N., Christof Birkenmaier, Jeffrey C. Wang, Andrew McDowell, Fahad S. Ahmed, Holger Brüggemann, Erin Coscia, et al. 2019. “A Review of Microscopy-Based Evidence for the Association of Propionibacterium Acnes Biofilms in Degenerative Disc Disease and Other Diseased Human Tissue.” European Spine Journal 28 (12): 2951–71. doi:10.1007/s00586-019-06086-y.
    • Harvard:
      Capoor, M. N. et al. (2019) ‘A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue’, European Spine Journal, 28(12), pp. 2951–2971. doi: 10.1007/s00586-019-06086-y.
    • Harvard: Australian:
      Capoor, MN, Birkenmaier, C, Wang, JC, McDowell, A, Ahmed, FS, Brüggemann, H, Coscia, E, Davies, DG, Ohrt-Nissen, S, Raz, A, Ruzicka, F, Schmitz, JE, Fischetti, VA & Slaby, O 2019, ‘A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue’, European Spine Journal, vol. 28, no. 12, pp. 2951–2971, viewed 5 December 2020, .
    • MLA:
      Capoor, Manu N., et al. “A Review of Microscopy-Based Evidence for the Association of Propionibacterium Acnes Biofilms in Degenerative Disc Disease and Other Diseased Human Tissue.” European Spine Journal, vol. 28, no. 12, Dec. 2019, pp. 2951–2971. EBSCOhost, doi:10.1007/s00586-019-06086-y.
    • Chicago/Turabian: Humanities:
      Capoor, Manu N., Christof Birkenmaier, Jeffrey C. Wang, Andrew McDowell, Fahad S. Ahmed, Holger Brüggemann, Erin Coscia, et al. “A Review of Microscopy-Based Evidence for the Association of Propionibacterium Acnes Biofilms in Degenerative Disc Disease and Other Diseased Human Tissue.” European Spine Journal 28, no. 12 (December 2019): 2951–71. doi:10.1007/s00586-019-06086-y.
    • Vancouver/ICMJE:
      Capoor MN, Birkenmaier C, Wang JC, McDowell A, Ahmed FS, Brüggemann H, et al. A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue. European Spine Journal [Internet]. 2019 Dec [cited 2020 Dec 5];28(12):2951–71. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=139827182