Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder.

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  • Additional Information
    • Affiliation:
      Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, Mail Unit 78, 10032, New York, NY, USA
      New York State Psychiatric Institute, 1051 Riverside Drive, 10032, New York, NY, USA
      New York-Presbyterian Hospital, Center for Autism and the Developing Brain, 21 Bloomingdale Rd, 10605, White Plains, NY, USA
      Sydney Children's Hospital, Community Health Center, High Street, 2031, Randwick, NSW, Australia
      Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street, 60612, Chicago, IL, USA
      Child Study Center, Yale University, 230 South Frontage Rd, 06519, New Haven, CT, USA
      Department of Pharmacology, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, 465 21st Avenue South, 37232, Nashville, TN, USA
      Department of Psychiatry, University of Minnesota, 2450 Riverside Ave, 55454, Minneapolis, MN, USA
      Dole Human Development Center, University of Kansas, 1000 Sunnyside Avenue, 66045, Lawrence, KS, USA
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.
    • Journal Subset:
      Biomedical; Peer Reviewed; USA
    • ISSN:
      0162-3257
    • MEDLINE Info:
      NLM UID: 7904301
    • Publication Date:
      20190606
    • Publication Date:
      20200601
    • DOI:
      10.1007/s10803-019-03989-z
    • Accession Number:
      136787193
  • Citations
    • ABNT:
      AARON, E. et al. Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder. Journal of Autism & Developmental Disorders, [s. l.], v. 49, n. 6, p. 2417–2425, 2019. DOI 10.1007/s10803-019-03989-z. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=136787193. Acesso em: 29 set. 2020.
    • AMA:
      Aaron E, Montgomery A, Ren X, et al. Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder. Journal of Autism & Developmental Disorders. 2019;49(6):2417-2425. doi:10.1007/s10803-019-03989-z
    • APA:
      Aaron, E., Montgomery, A., Ren, X., Guter, S., Anderson, G., Carneiro, A. M. D., Jacob, S., Mosconi, M., Pandey, G. N., Cook, E., & Veenstra-VanderWeele, J. (2019). Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder. Journal of Autism & Developmental Disorders, 49(6), 2417–2425. https://doi.org/10.1007/s10803-019-03989-z
    • Chicago/Turabian: Author-Date:
      Aaron, Elizabeth, Alicia Montgomery, Xinguo Ren, Stephen Guter, George Anderson, Ana M. D. Carneiro, Suma Jacob, et al. 2019. “Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder.” Journal of Autism & Developmental Disorders 49 (6): 2417–25. doi:10.1007/s10803-019-03989-z.
    • Harvard:
      Aaron, E. et al. (2019) ‘Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder’, Journal of Autism & Developmental Disorders, 49(6), pp. 2417–2425. doi: 10.1007/s10803-019-03989-z.
    • Harvard: Australian:
      Aaron, E, Montgomery, A, Ren, X, Guter, S, Anderson, G, Carneiro, AMD, Jacob, S, Mosconi, M, Pandey, GN, Cook, E & Veenstra-VanderWeele, J 2019, ‘Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder’, Journal of Autism & Developmental Disorders, vol. 49, no. 6, pp. 2417–2425, viewed 29 September 2020, .
    • MLA:
      Aaron, Elizabeth, et al. “Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder.” Journal of Autism & Developmental Disorders, vol. 49, no. 6, June 2019, pp. 2417–2425. EBSCOhost, doi:10.1007/s10803-019-03989-z.
    • Chicago/Turabian: Humanities:
      Aaron, Elizabeth, Alicia Montgomery, Xinguo Ren, Stephen Guter, George Anderson, Ana M. D. Carneiro, Suma Jacob, et al. “Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder.” Journal of Autism & Developmental Disorders 49, no. 6 (June 2019): 2417–25. doi:10.1007/s10803-019-03989-z.
    • Vancouver/ICMJE:
      Aaron E, Montgomery A, Ren X, Guter S, Anderson G, Carneiro AMD, et al. Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder. Journal of Autism & Developmental Disorders [Internet]. 2019 Jun [cited 2020 Sep 29];49(6):2417–25. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=136787193