Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.

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  • Additional Information
    • Affiliation:
      Imperial College Healthcare National Health Service (NHS) Trust, London, United Kingdom
      Imperial College London, London, United Kingdom
      Osaka International Cancer Institute, Osaka, Japan
      Necker University Hospital, Paris, France
      American University of Beirut, Beirut, Lebanon
      University of Miami, Miami, FL
      Washington University School of Medicine, St Louis, MO
      Memorial Sloan Kettering Cancer Center, New York, NY
      Guys and St Thomas Hospital, Kings Health Partners, London, United Kingdom
      Fundeni Clinical Institute, Bucharest, Romania
      Emergency University Hospital, Bucharest, Romania
      University College London Hospitals NHS Trust, London, United Kingdom
      National Cancer Institute, Bethesda, MD
      Universidade Federal da Bahia, Salvador, Brazil
      Weill Cornell Medical College, New York, NY
      University of Nebraska, Omaha, NE
      Mashhad University of Medical Sciences, Mashhad, Iran
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Purpose: Adult T-cell leukemia-lymphoma (ATL) is a distinct mature T-cell malignancy caused by chronic infection with human T-lymphotropic virus type 1 with diverse clinical features and prognosis. ATL remains a challenging disease as a result of its diverse clinical features, multidrug resistance of malignant cells, frequent large tumor burden, hypercalcemia, and/or frequent opportunistic infection. In 2009, we published a consensus report to define prognostic factors, clinical subclassifications, treatment strategies, and response criteria. The 2009 consensus report has become the standard reference for clinical trials in ATL and a guide for clinical management. Since the last consensus there has been progress in the understanding of the molecular pathophysiology of ATL and risk-adapted treatment approaches.Methods: Reflecting these advances, ATL researchers and clinicians joined together at the 18th International Conference on Human Retrovirology-Human T-Lymphotropic Virus and Related Retroviruses-in Tokyo, Japan, March, 2017, to review evidence for current clinical practice and to update the consensus with a new focus on the subtype classification of cutaneous ATL, CNS lesions in aggressive ATL, management of elderly or transplantation-ineligible patients, and treatment strategies that incorporate up-front allogeneic hematopoietic stem-cell transplantation and novel agents.Results: As a result of lower-quality clinical evidence, a best practice approach was adopted and consensus statements agreed on by coauthors (> 90% agreement).Conclusion: This expert consensus highlights the need for additional clinical trials to develop novel standard therapies for the treatment of ATL.
    • Journal Subset:
      Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA
    • Instrumentation:
      Disease Activity Score (DAS)
    • ISSN:
      0732-183X
    • MEDLINE Info:
      PMID: NLM30657736 NLM UID: 8309333
    • Grant Information:
      /DH_/Department of Health/United Kingdom; P30 CA008748/CA/NCI NIH HHS/United States
    • Publication Date:
      In Process
    • Publication Date:
      20200312
    • DOI:
      10.1200/JCO.18.00501
    • Accession Number:
      135109503
  • Citations
    • ABNT:
      COOK, L. B. et al. Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. Journal of Clinical Oncology, [s. l.], v. 38, n. 8, p. 677–687, 2019. DOI 10.1200/JCO.18.00501. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=135109503. Acesso em: 26 nov. 2020.
    • AMA:
      Cook LB, Fuji S, Hermine O, et al. Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. Journal of Clinical Oncology. 2019;38(8):677-687. doi:10.1200/JCO.18.00501
    • APA:
      Cook, L. B., Fuji, S., Hermine, O., Bazarbachi, A., Ramos, J. C., Ratner, L., Horwitz, S., Fields, P., Tanase, A., Bumbea, H., Cwynarski, K., Taylor, G., Waldmann, T. A., Bittencourt, A., Marcais, A., Suarez, F., Sibon, D., Phillips, A., Lunning, M., & Farid, R. (2019). Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. Journal of Clinical Oncology, 38(8), 677–687. https://doi.org/10.1200/JCO.18.00501
    • Chicago/Turabian: Author-Date:
      Cook, Lucy B., Shigeo Fuji, Olivier Hermine, Ali Bazarbachi, Juan Carlos Ramos, Lee Ratner, Steve Horwitz, et al. 2019. “Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.” Journal of Clinical Oncology 38 (8): 677–87. doi:10.1200/JCO.18.00501.
    • Harvard:
      Cook, L. B. et al. (2019) ‘Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report’, Journal of Clinical Oncology, 38(8), pp. 677–687. doi: 10.1200/JCO.18.00501.
    • Harvard: Australian:
      Cook, LB, Fuji, S, Hermine, O, Bazarbachi, A, Ramos, JC, Ratner, L, Horwitz, S, Fields, P, Tanase, A, Bumbea, H, Cwynarski, K, Taylor, G, Waldmann, TA, Bittencourt, A, Marcais, A, Suarez, F, Sibon, D, Phillips, A, Lunning, M & Farid, R 2019, ‘Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report’, Journal of Clinical Oncology, vol. 38, no. 8, pp. 677–687, viewed 26 November 2020, .
    • MLA:
      Cook, Lucy B., et al. “Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.” Journal of Clinical Oncology, vol. 38, no. 8, Mar. 2019, pp. 677–687. EBSCOhost, doi:10.1200/JCO.18.00501.
    • Chicago/Turabian: Humanities:
      Cook, Lucy B., Shigeo Fuji, Olivier Hermine, Ali Bazarbachi, Juan Carlos Ramos, Lee Ratner, Steve Horwitz, et al. “Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.” Journal of Clinical Oncology 38, no. 8 (March 10, 2019): 677–87. doi:10.1200/JCO.18.00501.
    • Vancouver/ICMJE:
      Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, et al. Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. Journal of Clinical Oncology [Internet]. 2019 Mar 10 [cited 2020 Nov 26];38(8):677–87. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=135109503