Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines.

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  • Additional Information
    • Affiliation:
      Duke University School of Medicine, Durham, USA
      Department of Radiology, Duke University Medical Center, USA
      Department of Orthopedic Surgery, Duke University Medical Center, USA
      Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor - UCLA Medical Center, USA
      Department of Animal Science, Iowa State University, USA
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Purpose: We compared fractional anisotropy and radial diffusivity measurements between pediatric canines affected with mucopolysaccharidosis I and pediatric control canines. We hypothesized that lower fractional anisotropy and higher radial diffusivity values, consistent with dysmyelination, would be present in the mucopolysaccharidosis I cohort. Methods: Six canine brains, three affected with mucopolysaccharidosis I and three unaffected, were euthanized at 7 weeks and imaged using a 7T small-animal magnetic resonance imaging system. Average fractional anisotropy and radial diffusivity values were calculated for four white-matter regions based on 100 regions of interest per region per specimen. A 95% confidence interval was calculated for each mean value. Results: No difference was seen in fractional anisotropy or radial diffusivity values between mucopolysaccharidosis affected and unaffected brains in any region. In particular, the 95% confidence intervals for mucopolysaccharidosis affected and unaffected canines frequently overlapped for both fractional anisotropy and radial diffusivity measurements. In addition, in some brain regions a large range of fractional anisotropy and radial diffusivity values were seen within the same cohort. Conclusion: The fractional anisotropy and radial diffusivity values of white matter did not differ between pediatric mucopolysaccharidosis affected canines and pediatric control canines. Possible explanations include: (a) a lack of white matter tissue differences between mucopolysaccharidosis affected and unaffected brains at early disease stages; (b) diffusion tensor imaging does not detect any existing differences; (c) inflammatory processes such as astrogliosis produce changes that offset the decreased fractional anisotropy values and increased radial diffusivity values that are expected in dysmyelination; and (d) our sample size was insufficient to detect differences. Further studies correlating diffusion tensor imaging findings to histology are warranted.
    • Journal Subset:
      Biomedical; Continental Europe; Europe
    • ISSN:
      1971-4009
    • MEDLINE Info:
      NLM UID: 101295103
    • Publication Date:
      20170922
    • Publication Date:
      20170922
    • DOI:
      http://dx.doi.org/10.1177/1971400917718844
    • Accession Number:
      125227453
  • Citations
    • ABNT:
      MIDDLETON, D. M. et al. Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines. Neuroradiology Journal, [s. l.], v. 30, n. 5, p. 454–460, 2017. DOI 10.1177/1971400917718844. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=125227453. Acesso em: 14 ago. 2020.
    • AMA:
      Middleton DM, Li JY, Chen SD, et al. Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines. Neuroradiology Journal. 2017;30(5):454-460. doi:10.1177/1971400917718844
    • APA:
      Middleton, D. M., Li, J. Y., Chen, S. D., White, L. E., Dickson, P. I., Ellinwood, N. M., & Provenzale, J. M. (2017). Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines. Neuroradiology Journal, 30(5), 454–460. https://doi.org/10.1177/1971400917718844
    • Chicago/Turabian: Author-Date:
      Middleton, Dana M., Jonathan Y. Li, Steven D. Chen, Leonard E. White, Patricia I. Dickson, N. Matthew Ellinwood, and James M. Provenzale. 2017. “Quantitative Diffusion Tensor Imaging Analysis Does Not Distinguish Pediatric Canines with Mucopolysaccharidosis I from Control Canines.” Neuroradiology Journal 30 (5): 454–60. doi:10.1177/1971400917718844.
    • Harvard:
      Middleton, D. M. et al. (2017) ‘Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines’, Neuroradiology Journal, 30(5), pp. 454–460. doi: 10.1177/1971400917718844.
    • Harvard: Australian:
      Middleton, DM, Li, JY, Chen, SD, White, LE, Dickson, PI, Ellinwood, NM & Provenzale, JM 2017, ‘Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines’, Neuroradiology Journal, vol. 30, no. 5, pp. 454–460, viewed 14 August 2020, .
    • MLA:
      Middleton, Dana M., et al. “Quantitative Diffusion Tensor Imaging Analysis Does Not Distinguish Pediatric Canines with Mucopolysaccharidosis I from Control Canines.” Neuroradiology Journal, vol. 30, no. 5, Oct. 2017, pp. 454–460. EBSCOhost, doi:10.1177/1971400917718844.
    • Chicago/Turabian: Humanities:
      Middleton, Dana M., Jonathan Y. Li, Steven D. Chen, Leonard E. White, Patricia I. Dickson, N. Matthew Ellinwood, and James M. Provenzale. “Quantitative Diffusion Tensor Imaging Analysis Does Not Distinguish Pediatric Canines with Mucopolysaccharidosis I from Control Canines.” Neuroradiology Journal 30, no. 5 (October 2017): 454–60. doi:10.1177/1971400917718844.
    • Vancouver/ICMJE:
      Middleton DM, Li JY, Chen SD, White LE, Dickson PI, Ellinwood NM, et al. Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines. Neuroradiology Journal [Internet]. 2017 Oct [cited 2020 Aug 14];30(5):454–60. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=125227453