High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India.

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  • Additional Information
    • Affiliation:
      Byramjee Jeejeebhoy Government Medical College–Johns Hopkins University Clinical Research Site, Pune, India.
      Johns Hopkins University School of Medicine, Baltimore, Maryland.
      Byramjee Jeejeebhoy Government Medical College, Pune, India.
      Tulane University School of Medicine, New Orleans, Louisiana.
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background: In India, antimicrobial consumption is high, yet systematically collected data on the epidemiology, risk factors, and outcomes of antimicrobial-resistant infections are limited.Methods: A prospective study of adults and children hospitalized for acute febrile illness was conducted between August 2013 and December 2015. In-hospital outcomes were recorded, and logistic regression was performed to identify independent predictors of community-onset antimicrobial-resistant infections.Results: Among 1524 patients hospitalized with acute febrile illness, 133 isolates were found among 115 patients with community-onset infections; 66 isolates (50.0%) were multidrug resistant and, of 33 isolates tested for carbapenem susceptibility, 12 (36%) were resistant. Multidrug-resistant infections were associated with recent antecedent antibiotic use (adjusted odds ratio [aOR], 4.17; 95% confidence interval [CI], 1.19-19.7) and were independently associated with mortality (aOR, 6.06; 95% CI, 1.2-55.7).Conclusion: We found a high burden of community-onset antimicrobial-resistant infection among patients with acute febrile illness in India. Multidrug-resistant infection was associated with prior antibiotic use and an increased risk of mortality.
    • Journal Subset:
      Biomedical; Editorial Board Reviewed; Peer Reviewed; USA
    • ISSN:
      0022-1899
    • MEDLINE Info:
      PMID: NLM28329303 NLM UID: 0413675
    • Publication Date:
      20170806
    • Publication Date:
      20180516
    • DOI:
      http://dx.doi.org/10.1093/infdis/jix114
    • Accession Number:
      123591459
  • Citations
    • ABNT:
      MAVE, V. et al. High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India. Journal of Infectious Diseases, [s. l.], v. 215, n. 8, p. 1312–1320, 2017. DOI 10.1093/infdis/jix114. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=123591459. Acesso em: 3 ago. 2020.
    • AMA:
      Mave V, Chandanwale A, Kagal A, et al. High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India. Journal of Infectious Diseases. 2017;215(8):1312-1320. doi:10.1093/infdis/jix114.
    • AMA11:
      Mave V, Chandanwale A, Kagal A, et al. High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India. Journal of Infectious Diseases. 2017;215(8):1312-1320. doi:10.1093/infdis/jix114
    • APA:
      Mave, V., Chandanwale, A., Kagal, A., Khadse, S., Kadam, D., Bharadwaj, R., Dohe, V., Robinson, M. L., Kinikar, A., Joshi, S., Raichur, P., McIntire, K., Kanade, S., Sachs, J., Valvi, C., Balasubramanian, U., Kulkarni, V., Milstone, A. M., Marbaniang, I., & Zenilman, J. (2017). High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India. Journal of Infectious Diseases, 215(8), 1312–1320. https://doi.org/10.1093/infdis/jix114
    • Chicago/Turabian: Author-Date:
      Mave, Vidya, Ajay Chandanwale, Anju Kagal, Sandhya Khadse, Dileep Kadam, Renu Bharadwaj, Vaishali Dohe, et al. 2017. “High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India.” Journal of Infectious Diseases 215 (8): 1312–20. doi:10.1093/infdis/jix114.
    • Harvard:
      Mave, V. et al. (2017) ‘High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India’, Journal of Infectious Diseases, 215(8), pp. 1312–1320. doi: 10.1093/infdis/jix114.
    • Harvard: Australian:
      Mave, V, Chandanwale, A, Kagal, A, Khadse, S, Kadam, D, Bharadwaj, R, Dohe, V, Robinson, ML, Kinikar, A, Joshi, S, Raichur, P, McIntire, K, Kanade, S, Sachs, J, Valvi, C, Balasubramanian, U, Kulkarni, V, Milstone, AM, Marbaniang, I & Zenilman, J 2017, ‘High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India’, Journal of Infectious Diseases, vol. 215, no. 8, pp. 1312–1320, viewed 3 August 2020, .
    • MLA:
      Mave, Vidya, et al. “High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India.” Journal of Infectious Diseases, vol. 215, no. 8, Apr. 2017, pp. 1312–1320. EBSCOhost, doi:10.1093/infdis/jix114.
    • Chicago/Turabian: Humanities:
      Mave, Vidya, Ajay Chandanwale, Anju Kagal, Sandhya Khadse, Dileep Kadam, Renu Bharadwaj, Vaishali Dohe, et al. “High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India.” Journal of Infectious Diseases 215, no. 8 (April 15, 2017): 1312–20. doi:10.1093/infdis/jix114.
    • Vancouver/ICMJE:
      Mave V, Chandanwale A, Kagal A, Khadse S, Kadam D, Bharadwaj R, et al. High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India. Journal of Infectious Diseases [Internet]. 2017 Apr 15 [cited 2020 Aug 3];215(8):1312–20. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=123591459