Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study.

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  • Additional Information
    • Affiliation:
      Department of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland
      Department of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland; Department of Internal Medicine, Lapland Central Hospital, Finland
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Results from epidemiologic studies on the association between circulating carotenoid concentrations and the risk of prostate cancer are still inconsistent. We studied whether serum concentrations of carotenoids were associated with the risk of developing prostate cancer. The study population consisted of 997 middle-aged Finnish men (56.1 ± 6.6 yr) in the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) cohort. Serum concentrations of carotenoids were measured by high-performance liquid chromatography. Subjects were classified into tertiles according to their serum concentrations of antioxidants. Relative risks (RRs) were estimated by using the Cox proportional hazard models. During the mean follow-up time of 15 yr, a total of 68 prostate cancer cases occurred. After adjusting for age, examination yr, family history of cancer, BMI, pack-yr of smoking, alcohol consumption, education, physical activity, serum total cholesterol, and serum α-linolenic acid, men in the highest tertile of serum concentrations of β-carotene had 2.3-fold higher risk of prostate cancer as compared to those in the lowest tertile (RR = 2.29, 95% CI: 1.12–4.66; P = 0.023). α-Tocopherol and retinol were not associated with prostate cancer. This prospective study suggests that high-serum β-carotene concentrations may increase the risk of prostate cancer in middle-aged men.
    • Journal Subset:
      Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA
    • Special Interest:
      Nutrition; Oncologic Care
    • ISSN:
      0163-5581
    • MEDLINE Info:
      NLM UID: 7905040
    • Publication Date:
      20120430
    • Publication Date:
      20171010
    • DOI:
      http://dx.doi.org/10.1080/01635581.2012.658949
    • Accession Number:
      104548103
  • Citations
    • ABNT:
      KARPPI, J. et al. Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study. Nutrition & Cancer, [s. l.], v. 64, n. 3, p. 361–367, 2012. DOI 10.1080/01635581.2012.658949. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=104548103. Acesso em: 7 ago. 2020.
    • AMA:
      Karppi J, Kurl S, Laukkanen JA, Kauhanen J. Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study. Nutrition & Cancer. 2012;64(3):361-367. doi:10.1080/01635581.2012.658949
    • APA:
      Karppi, J., Kurl, S., Laukkanen, J. A., & Kauhanen, J. (2012). Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study. Nutrition & Cancer, 64(3), 361–367. https://doi.org/10.1080/01635581.2012.658949
    • Chicago/Turabian: Author-Date:
      Karppi, Jouni, Sudhir Kurl, Jari A. Laukkanen, and Jussi Kauhanen. 2012. “Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study.” Nutrition & Cancer 64 (3): 361–67. doi:10.1080/01635581.2012.658949.
    • Harvard:
      Karppi, J. et al. (2012) ‘Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study’, Nutrition & Cancer, 64(3), pp. 361–367. doi: 10.1080/01635581.2012.658949.
    • Harvard: Australian:
      Karppi, J, Kurl, S, Laukkanen, JA & Kauhanen, J 2012, ‘Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study’, Nutrition & Cancer, vol. 64, no. 3, pp. 361–367, viewed 7 August 2020, .
    • MLA:
      Karppi, Jouni, et al. “Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study.” Nutrition & Cancer, vol. 64, no. 3, Apr. 2012, pp. 361–367. EBSCOhost, doi:10.1080/01635581.2012.658949.
    • Chicago/Turabian: Humanities:
      Karppi, Jouni, Sudhir Kurl, Jari A. Laukkanen, and Jussi Kauhanen. “Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study.” Nutrition & Cancer 64, no. 3 (April 2012): 361–67. doi:10.1080/01635581.2012.658949.
    • Vancouver/ICMJE:
      Karppi J, Kurl S, Laukkanen JA, Kauhanen J. Serum β-Carotene in Relation to Risk of Prostate Cancer: The Kuopio Ischaemic Heart Disease Risk Factor Study. Nutrition & Cancer [Internet]. 2012 Apr [cited 2020 Aug 7];64(3):361–7. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=104548103