The Genetic Background of Metabolic Trait Clusters in Children and Adolescents.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101150318 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8518 (Electronic) Linking ISSN: 15404196 NLM ISO Abbreviation: Metab Syndr Relat Disord Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2003-
    • Subject Terms:
    • Abstract:
      Background: It is well known that metabolic risk factors of cardiovascular diseases are correlated, but the background of this clustering in children is more poorly known than in adults. Thus, we studied the contribution of genetic and environmental factors to the clustering of metabolic traits in childhood and adolescence.
      Data and Methods: Nine metabolic traits were measured in 214 complete twin pairs aged 3-18 years in the Autonomous Region of Madeira, Portugal, in 2007 and 2008. The variation of and covariations between the traits were decomposed into genetic and environmental components by using classical genetic twin modeling.
      Results: A model, including additive genetic and environmental factors unique for each twin individual, explained the variation of metabolic factors well. Under this model, the heritability estimates varied from 0.47 (systolic blood pressure in children under 12 years of age) to 0.91 (high-density lipoprotein [HDL] cholesterol in adolescents 12 years of age or older). The most systematic correlations were found between adiposity (body mass index and waist circumference) and blood lipids (HDL cholesterol, low-density lipoprotein cholesterol, and triglycerides), as well as blood pressure. These correlations were mainly explained by common genetic factors.
      Conclusions: Our results suggest that obesity, in particular, is behind the clustering of metabolic factors in children and adolescents. Both general and abdominal obesity partly share the same genetic background as blood lipids and blood pressure. Obesity prevention early in childhood is important in reducing the risk of metabolic diseases in adulthood.
    • Contributed Indexing:
      Keywords: adolescents*; children*; genetics*; metabolic syndrome*; twins*
    • Accession Number:
      0 (Cholesterol, HDL)
      0 (Cholesterol, LDL)
    • Publication Date:
      Date Created: 20170721 Date Completed: 20180607 Latest Revision: 20180806
    • Publication Date:
      20200527
    • Accession Number:
      10.1089/met.2017.0013
    • Accession Number:
      28727943
  • Citations
    • ABNT:
      SILVENTOINEN, K. et al. The Genetic Background of Metabolic Trait Clusters in Children and Adolescents. Metabolic syndrome and related disorders, [s. l.], v. 15, n. 7, p. 329–336, 2017. DOI 10.1089/met.2017.0013. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mnh&AN=28727943. Acesso em: 5 ago. 2020.
    • AMA:
      Silventoinen K, Gouveia É, Jelenkovic A, et al. The Genetic Background of Metabolic Trait Clusters in Children and Adolescents. Metabolic syndrome and related disorders. 2017;15(7):329-336. doi:10.1089/met.2017.0013.
    • AMA11:
      Silventoinen K, Gouveia É, Jelenkovic A, et al. The Genetic Background of Metabolic Trait Clusters in Children and Adolescents. Metabolic syndrome and related disorders. 2017;15(7):329-336. doi:10.1089/met.2017.0013
    • APA:
      Silventoinen, K., Gouveia, É., Jelenkovic, A., Maia, J., Antunes, A. M., Pinheiro de Carvalho, M. A. A., Brehm, A. M., Thomis, M., Lefevre, J., Kaprio, J., & Freitas, D. (2017). The Genetic Background of Metabolic Trait Clusters in Children and Adolescents. Metabolic Syndrome and Related Disorders, 15(7), 329–336. https://doi.org/10.1089/met.2017.0013
    • Chicago/Turabian: Author-Date:
      Silventoinen, Karri, Élvio Gouveia, Aline Jelenkovic, José Maia, António M Antunes, Miguel A A Pinheiro de Carvalho, António M Brehm, et al. 2017. “The Genetic Background of Metabolic Trait Clusters in Children and Adolescents.” Metabolic Syndrome and Related Disorders 15 (7): 329–36. doi:10.1089/met.2017.0013.
    • Harvard:
      Silventoinen, K. et al. (2017) ‘The Genetic Background of Metabolic Trait Clusters in Children and Adolescents’, Metabolic syndrome and related disorders, 15(7), pp. 329–336. doi: 10.1089/met.2017.0013.
    • Harvard: Australian:
      Silventoinen, K, Gouveia, É, Jelenkovic, A, Maia, J, Antunes, AM, Pinheiro de Carvalho, MAA, Brehm, AM, Thomis, M, Lefevre, J, Kaprio, J & Freitas, D 2017, ‘The Genetic Background of Metabolic Trait Clusters in Children and Adolescents’, Metabolic syndrome and related disorders, vol. 15, no. 7, pp. 329–336, viewed 5 August 2020, .
    • MLA:
      Silventoinen, Karri, et al. “The Genetic Background of Metabolic Trait Clusters in Children and Adolescents.” Metabolic Syndrome and Related Disorders, vol. 15, no. 7, Sept. 2017, pp. 329–336. EBSCOhost, doi:10.1089/met.2017.0013.
    • Chicago/Turabian: Humanities:
      Silventoinen, Karri, Élvio Gouveia, Aline Jelenkovic, José Maia, António M Antunes, Miguel A A Pinheiro de Carvalho, António M Brehm, et al. “The Genetic Background of Metabolic Trait Clusters in Children and Adolescents.” Metabolic Syndrome and Related Disorders 15, no. 7 (September 2017): 329–36. doi:10.1089/met.2017.0013.
    • Vancouver/ICMJE:
      Silventoinen K, Gouveia É, Jelenkovic A, Maia J, Antunes AM, Pinheiro de Carvalho MAA, et al. The Genetic Background of Metabolic Trait Clusters in Children and Adolescents. Metabolic syndrome and related disorders [Internet]. 2017 Sep [cited 2020 Aug 5];15(7):329–36. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mnh&AN=28727943