A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia

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  • Additional Information
    • Affiliation:
      1 Wellcome Trust Centre for Human Genetics, Oxford
      2 Department of Physiology, University of Oxford, Oxford
      3 Department of Human Genetics, University of Pittsburgh, Pittsburgh
    • Keywords:
      Developmental dyslexia
      Reading disability
      Quantitative-trait locus
      Chromosome 6p21.3
      Variance components
      Sib-pair methods
    • Subject Terms:
    • Abstract:
      Summary Recent application of nonparametric-linkage analysis to reading disability has implicated a putative quantitative-trait locus (QTL) on the short arm of chromosome 6. In the present study, we use QTL methods to evaluate linkage to the 6p25-21.3 region in a sample of 181 sib pairs from 82 nuclear families that were selected on the basis of a dyslexic proband. We have assessed linkage directly for several quantitative measures that should correlate with different components of the phenotype, rather than using a single composite measure or employing categorical definitions of subtypes. Our measures include the traditional IQ/reading discrepancy score, as well as tests of word recognition, irregular-word reading, and nonword reading. Pointwise analysis by means of sib-pair trait differences suggests the presence, in 6p21.3, of a QTL influencing multiple components of dyslexia, in particular the reading of irregular words ( P=.0016) and nonwords ( P=.0024). A complementary statistical approach involving estimation of variance components supports these findings (irregular words, P=.007; nonwords, P=.0004). Multipoint analyses place the QTL within the D6S422-D6S291 interval, with a peak around markers D6S276 and D6S105 consistently identified by approaches based on trait differences (irregular words, P=.00035; nonwords, P=.0035) and variance components (irregular words, P=.007; nonwords, P=.0038). Our findings indicate that the QTL affects both phonological and orthographic skills and is not specific to phoneme awareness, as has been previously suggested. Further studies will be necessary to obtain a more precise localization of this QTL, which may lead to the isolation of one of the genes involved in developmental dyslexia.
    • ISSN:
      0002-9297
    • Accession Number:
      10.1086/302190
    • Accession Number:
      S000292970761667X
    • Copyright:
      Copyright @ 1999 The American Society of Human Genetics Published by Elsevier Inc. All rights reserved.
  • Citations
    • ABNT:
      FISHER, S. E. et al. A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia. The American Journal of Human Genetics, [s. l.], v. 64, n. 1, p. 146–156, 1999. DOI 10.1086/302190. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S000292970761667X. Acesso em: 11 jul. 2020.
    • AMA:
      Fisher SE, Marlow AJ, Lamb J, et al. A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia. The American Journal of Human Genetics. 1999;64(1):146-156. doi:10.1086/302190.
    • AMA11:
      Fisher SE, Marlow AJ, Lamb J, et al. A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia. The American Journal of Human Genetics. 1999;64(1):146-156. doi:10.1086/302190
    • APA:
      Fisher, S. E., Marlow, A. J., Lamb, J., Maestrini, E., Williams, D. F., Richardson, A. J., Weeks, D. E., Stein, J. F., & Monaco, A. P. (1999). A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia. The American Journal of Human Genetics, 64(1), 146–156. https://doi.org/10.1086/302190
    • Chicago/Turabian: Author-Date:
      Fisher, Simon E., Angela J. Marlow, Janine Lamb, Elena Maestrini, Dianne F. Williams, Alex J. Richardson, Daniel E. Weeks, John F. Stein, and Anthony P. Monaco. 1999. “A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia.” The American Journal of Human Genetics 64 (1): 146–56. doi:10.1086/302190.
    • Harvard:
      Fisher, S. E. et al. (1999) ‘A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia’, The American Journal of Human Genetics, 64(1), pp. 146–156. doi: 10.1086/302190.
    • Harvard: Australian:
      Fisher, SE, Marlow, AJ, Lamb, J, Maestrini, E, Williams, DF, Richardson, AJ, Weeks, DE, Stein, JF & Monaco, AP 1999, ‘A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia’, The American Journal of Human Genetics, vol. 64, no. 1, pp. 146–156, viewed 11 July 2020, .
    • MLA:
      Fisher, Simon E., et al. “A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia.” The American Journal of Human Genetics, vol. 64, no. 1, Jan. 1999, pp. 146–156. EBSCOhost, doi:10.1086/302190.
    • Chicago/Turabian: Humanities:
      Fisher, Simon E., Angela J. Marlow, Janine Lamb, Elena Maestrini, Dianne F. Williams, Alex J. Richardson, Daniel E. Weeks, John F. Stein, and Anthony P. Monaco. “A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia.” The American Journal of Human Genetics 64, no. 1 (January 1, 1999): 146–56. doi:10.1086/302190.
    • Vancouver/ICMJE:
      Fisher SE, Marlow AJ, Lamb J, Maestrini E, Williams DF, Richardson AJ, et al. A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia. The American Journal of Human Genetics [Internet]. 1999 Jan 1 [cited 2020 Jul 11];64(1):146–56. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S000292970761667X