Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells

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  • Additional Information
    • Publication Information:
      USA: IEEE
    • Publication Date:
      2020
    • Abstract:
      Gallium nitride (GaN) is a compound semiconductor which has advantages to generate new functionalities and applications due to its piezoelectric, pyroelectric, and piezo-resistive properties. Recently, surface acoustic wave (SAW)-based acoustic tweezers were developed as an efficient and versatile tool to manipulate nano- and microparticles aiming for patterning, separating, and mixing biological and chemical components. Conventional piezoelectric materials to fabricate SAW devices such as lithium niobate suffer from its low thermal conductivity and incapability of fabricating multiphysical and integrated devices. This article piloted the development of a GaN-based acoustic tweezer (GaNAT) and its application in manipulating microparticles and biological cells. For the first time, the GaN SAW device was integrated with a microfluidic channel to form an acoustofluidic chip for biological applications. The GaNAT demonstrated its ability to work on high power (up to 10 W) with minimal cooling requirement while maintaining the device temperature below 32°C. Acoustofluidic modeling was successfully applied to numerically study and predict acoustic pressure field and particle trajectories within the GaNAT, which agree well with the experimental results on patterning polystyrene microspheres and two types of biological cells including fibroblast and renal tumor cells. The GaNAT allowed both cell types to maintain high viabilities of 84.5% and 92.1%, respectively.
    • Author Affiliations:
      School of Life Sciences, Northwestern Polytechnical University, Xi’an, China
      Department of Electrical and Electronic Engineering, School of Engineering, Cardiff University, Cardiff, U.K.
      Division of Cancer and Genetics, Preclinical Studies of Renal Tumors Group, School of Medicine, Cardiff University, Cardiff, U.K.
      Department of Biomedical Engineering, School of Engineering, Duke University, Durham, NC, USA
      Department of Civil Engineering, School of Engineering, Cardiff University, Cardiff, U.K.
      Department of Engineering, University of Cambridge, Cambridge, U.K.
      Division of Cancer and Genetics, Tissue Microenvironment Group, School of Medicine, Cardiff University, Cardiff, U.K.
      Division of Infection and Immunity, School of Medicine, Systems Immunity University Research Institute, Cardiff University, Cardiff, U.K.
      School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian, China
      Faculty of Engineering and Environment, Northumbria University, Newcastle Upon Tyne, U.K.
      Department of Mechanical Engineering, Northwestern Polytechnical University, Xi’an, China
    • ISSN:
      0018-9383
      1557-9646
    • Accession Number:
      10.1109/TED.2020.3002498
    • Rights:
      Copyright 1963-2012, IEEE
    • AMSID:
      9124641
    • Date of Current Version:
      2020
    • Document Subtype:
      IEEE Transaction
    • Sponsored by:
      IEEE Electron Devices Society
    • Accession Number:
      edseee.9124641
  • Citations
    • ABNT:
      SUN, C. et al. Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells. IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans. Electron Devices, [s. l.], v. 67, n. 8, p. 3355–3361, 2020. DOI 10.1109/TED.2020.3002498. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edseee&AN=edseee.9124641. Acesso em: 28 set. 2020.
    • AMA:
      Sun C, Wu F, Wallis DJ, et al. Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells. IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans Electron Devices. 2020;67(8):3355-3361. doi:10.1109/TED.2020.3002498
    • APA:
      Sun, C., Wu, F., Wallis, D. J., Shen, M. H., Yuan, F., Yang, J., Wu, J., Xie, Z., Liang, D., Wang, H., Tickle, R., Mikhaylov, R., Clayton, A., Zhou, Y., Wu, Z., Fu, Y., Xun, W., & Yang, X. (2020). Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells. IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans. Electron Devices, 67(8), 3355–3361. https://doi.org/10.1109/TED.2020.3002498
    • Chicago/Turabian: Author-Date:
      Sun, C., F. Wu, D.J. Wallis, M.H. Shen, F. Yuan, J. Yang, J. Wu, et al. 2020. “Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells.” IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans. Electron Devices 67 (8): 3355–61. doi:10.1109/TED.2020.3002498.
    • Harvard:
      Sun, C. et al. (2020) ‘Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells’, IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans. Electron Devices, 67(8), pp. 3355–3361. doi: 10.1109/TED.2020.3002498.
    • Harvard: Australian:
      Sun, C, Wu, F, Wallis, DJ, Shen, MH, Yuan, F, Yang, J, Wu, J, Xie, Z, Liang, D, Wang, H, Tickle, R, Mikhaylov, R, Clayton, A, Zhou, Y, Wu, Z, Fu, Y, Xun, W & Yang, X 2020, ‘Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells’, IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans. Electron Devices, vol. 67, no. 8, pp. 3355–3361, viewed 28 September 2020, .
    • MLA:
      Sun, C., et al. “Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells.” IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans. Electron Devices, vol. 67, no. 8, Aug. 2020, pp. 3355–3361. EBSCOhost, doi:10.1109/TED.2020.3002498.
    • Chicago/Turabian: Humanities:
      Sun, C., F. Wu, D.J. Wallis, M.H. Shen, F. Yuan, J. Yang, J. Wu, et al. “Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells.” IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans. Electron Devices 67, no. 8 (August 1, 2020): 3355–61. doi:10.1109/TED.2020.3002498.
    • Vancouver/ICMJE:
      Sun C, Wu F, Wallis DJ, Shen MH, Yuan F, Yang J, et al. Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells. IEEE Transactions on Electron Devices, Electron Devices, IEEE Transactions on, IEEE Trans Electron Devices [Internet]. 2020 Aug 1 [cited 2020 Sep 28];67(8):3355–61. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edseee&AN=edseee.9124641