In-vivo cortical thickness estimation from high-resolution T1w MRI scans in healthy and mucopolysaccharidosis affected dogs

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  • Additional Information
    • Publication Information:
      IEEE
    • Publication Date:
      2019
    • Abstract:
      Cortical thickness measurement estimated from high-resolution anatomical MRI scans may serve as a marker of cortical atrophy in clinical research applications. Most of the working algorithms and pipelines are optimized for human in-vivo data analyses that offer robust and reproducible measures. As animal-models are widely utilized in many preclinical phases of clinical trials the need for an optimized automated MRI data analysis to yield reliable data is warranted. We present a processing pipeline optimized for cortical thickness estimation of canine brains in native and template spaces. Preliminary results of 5 healthy and 5 mucopolysaccharidosis (MPS) dogs demonstrate single-canine mean/median cortical thickness in range of 2.69-3.58mm in native space and 3.26-4.15mm in template space. Our MRI generated values exceed previous histological measurements (observed mean about 2mm) in limited literature reports. Randomly selected manual measures corroborated the ranges defined by estimated cortical thickness probability density functions. Geometric transformations between native and template spaces change absolute mean/median cortical thickness values, but do not change the data nature and properties since the Pearson correlation coefficients between different space estimates were 0.84 for mean values and 0.89 for median values. No significant difference in total cortical thickness between MPS and age-and gender-matched dogs was observed.
    • Contents Note:
      Conference Acronym: EMBC
    • Author Affiliations:
      Department of Pediatrics, University of Minnesota, Minneapolis, MN, 55414, USA
      Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, USA
      Department of Animal Science, Iowa State University, Ames, IA, 50011, USA
    • ISBN:
      978-1-5386-1311-5
    • ISSN:
      1558-4615
    • Relation:
      2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
    • Accession Number:
      10.1109/EMBC.2019.8856826
    • Rights:
      Copyright 2019, IEEE
    • AMSID:
      8856826
    • Conference Acronym:
      EMBC
    • Date of Current Version:
      2019
    • Document Subtype:
      IEEE Conference
    • Notes:
      Conference Location: Berlin, Germany, Germany

      Conference Start Date: 23 July 2019

      Conference End Date: 27 July 2019
    • Accession Number:
      edseee.8856826
  • Citations
    • ABNT:
      LABOUNEK, R. et al. In-vivo cortical thickness estimation from high-resolution T1w MRI scans in healthy and mucopolysaccharidosis affected dogs. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE, [s. l.], p. 2848–2851, 2019. DOI 10.1109/EMBC.2019.8856826. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edseee&AN=edseee.8856826. Acesso em: 2 dez. 2020.
    • AMA:
      Labounek R, Mai K, Mueller B, Ellinwood NM, Dickson P, Nestrasil I. In-vivo cortical thickness estimation from high-resolution T1w MRI scans in healthy and mucopolysaccharidosis affected dogs. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE. July 2019:2848-2851. doi:10.1109/EMBC.2019.8856826
    • APA:
      Labounek, R., Mai, K., Mueller, B., Ellinwood, N. M., Dickson, P., & Nestrasil, I. (2019). In-vivo cortical thickness estimation from high-resolution T1w MRI scans in healthy and mucopolysaccharidosis affected dogs. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE, 2848–2851. https://doi.org/10.1109/EMBC.2019.8856826
    • Chicago/Turabian: Author-Date:
      Labounek, Rene, Khoi Mai, Bryon Mueller, N. Matthew Ellinwood, Patricia Dickson, and Igor Nestrasil. 2019. “In-Vivo Cortical Thickness Estimation from High-Resolution T1w MRI Scans in Healthy and Mucopolysaccharidosis Affected Dogs.” 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE, July, 2848–51. doi:10.1109/EMBC.2019.8856826.
    • Harvard:
      Labounek, R. et al. (2019) ‘In-vivo cortical thickness estimation from high-resolution T1w MRI scans in healthy and mucopolysaccharidosis affected dogs’, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE, pp. 2848–2851. doi: 10.1109/EMBC.2019.8856826.
    • Harvard: Australian:
      Labounek, R, Mai, K, Mueller, B, Ellinwood, NM, Dickson, P & Nestrasil, I 2019, ‘In-vivo cortical thickness estimation from high-resolution T1w MRI scans in healthy and mucopolysaccharidosis affected dogs’, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE, pp. 2848–2851, viewed 2 December 2020, .
    • MLA:
      Labounek, Rene, et al. “In-Vivo Cortical Thickness Estimation from High-Resolution T1w MRI Scans in Healthy and Mucopolysaccharidosis Affected Dogs.” 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE, July 2019, pp. 2848–2851. EBSCOhost, doi:10.1109/EMBC.2019.8856826.
    • Chicago/Turabian: Humanities:
      Labounek, Rene, Khoi Mai, Bryon Mueller, N. Matthew Ellinwood, Patricia Dickson, and Igor Nestrasil. “In-Vivo Cortical Thickness Estimation from High-Resolution T1w MRI Scans in Healthy and Mucopolysaccharidosis Affected Dogs.” 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE, July 1, 2019, 2848–51. doi:10.1109/EMBC.2019.8856826.
    • Vancouver/ICMJE:
      Labounek R, Mai K, Mueller B, Ellinwood NM, Dickson P, Nestrasil I. In-vivo cortical thickness estimation from high-resolution T1w MRI scans in healthy and mucopolysaccharidosis affected dogs. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE [Internet]. 2019 Jul 1 [cited 2020 Dec 2];2848–51. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edseee&AN=edseee.8856826