Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain.

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  • Additional Information
    • Publication Year:
      2001
    • Author-Supplied Keywords:
      Agents
      Anesthesia
      Animals
      Anti-inflammatory
      DISEASE
      Effects
      ENDOSCOPY
      MEASUREMENT
      Model
      Nonsteroidal
      one-lung
      PAIN
      procedures
      research
      Therapeutic
      Toxic
      Veterinary
    • Abstract:
      Diminished tissue injury and shortened clinical recovery are benefits of using an endoscopic approach for patients needing operative procedure. In the course of developing an experimental model requiring procurement of topographically precise lung biopsy specimens, we sought to apply thoracoscopy as a research alternative to thoracotomy. In addition, we investigated the influence of thoracoscopy on postprocedure recovery practices using rabbits divided into four treatment groups. Rabbit groups 1 and 2 underwent thoracoscopy and lung biopsy while maintained by one-lung anesthesia. Additionally, group 2 had ketoprofen and bupivacaine HCl analgesics injected for treatment during postprocedure recovery. These two groups were compared to control rabbits in groups 3 and 4, which underwent inhalant anesthesia without thoracoscopy. Control group 3 also received the injection analgesic combination. During recovery, rabbit behavior was systematically assessed for evidence of pain. No behavior considered indicative of pain needing intervention was observed regardless of treatment group. Limited changes in plasma corticosterone, catecholamines, and prostaglandin E[sub 2] levels measured during recovery were difficult to associate with any treatment. Unexpectedly, significantly different mean corticosterone and catecholamines levels were detected in rabbits given the injection analgesic combination in the absence of thoracoscopic procedure, as compared to other treatment groups. The results highlight the importance of awareness that analgesic drug administration has the potential to alter homeostasis and affect interpretation of some study findings by its own guise. Correlation of the mean pain study results with plasma biochemical data supports preferential use of thoracoscopy as a refinement for limiting postprocedural pain in research models. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Investigative Surgery is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      08941939
    • Accession Number:
      4647471
  • Citations
    • ABNT:
      HAMPSHIRE, V. A. et al. Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain. Journal of Investigative Surgery, [s. l.], v. 14, n. 2, p. 109, 2001. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=4647471. Acesso em: 4 ago. 2020.
    • AMA:
      Hampshire VA, Thomas ML, Bacher JD, et al. Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain. Journal of Investigative Surgery. 2001;14(2):109. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=4647471. Accessed August 4, 2020.
    • AMA11:
      Hampshire VA, Thomas ML, Bacher JD, et al. Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain. Journal of Investigative Surgery. 2001;14(2):109. Accessed August 4, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=4647471
    • APA:
      Hampshire, V. A., Thomas, M. L., Bacher, J. D., Alling, D. W., Kindt, T. J., Wyatt, R. G., & Simpson, R. M. (2001). Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain. Journal of Investigative Surgery, 14(2), 109.
    • Chicago/Turabian: Author-Date:
      Hampshire, Victoria A., Marvin L. Thomas, John D. Bacher, David W. Alling, Thomas J. Kindt, Richard G. Wyatt, and R. Mark Simpson. 2001. “Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain.” Journal of Investigative Surgery 14 (2): 109. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=4647471.
    • Harvard:
      Hampshire, V. A. et al. (2001) ‘Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain’, Journal of Investigative Surgery, 14(2), p. 109. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=4647471 (Accessed: 4 August 2020).
    • Harvard: Australian:
      Hampshire, VA, Thomas, ML, Bacher, JD, Alling, DW, Kindt, TJ, Wyatt, RG & Simpson, RM 2001, ‘Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain’, Journal of Investigative Surgery, vol. 14, no. 2, p. 109, viewed 4 August 2020, .
    • MLA:
      Hampshire, Victoria A., et al. “Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain.” Journal of Investigative Surgery, vol. 14, no. 2, Mar. 2001, p. 109. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=4647471.
    • Chicago/Turabian: Humanities:
      Hampshire, Victoria A., Marvin L. Thomas, John D. Bacher, David W. Alling, Thomas J. Kindt, Richard G. Wyatt, and R. Mark Simpson. “Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain.” Journal of Investigative Surgery 14, no. 2 (March 2001): 109. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=4647471.
    • Vancouver/ICMJE:
      Hampshire VA, Thomas ML, Bacher JD, Alling DW, Kindt TJ, Wyatt RG, et al. Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain. Journal of Investigative Surgery [Internet]. 2001 Mar [cited 2020 Aug 4];14(2):109. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=4647471