An exploration of outcome criteria in nocturnal enuresis treatment.

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  • Additional Information
    • Publication Year:
      2004
    • Author-Supplied Keywords:
      dryness scale
      nocturnal enuresis
      outcome criteria
      outcome criteria.
    • Abstract:
      Objective: Standard treatment of muscle-infiltrated transitional cell carcinoma (TCC) of the urothelium consists of radical cystectomy. In some cases there is a delay between the initial diagnosis and a definitive treatment being administered. The objective of this study was to determine the effect of the time window between evidence of muscle invasion and radical cystectomy on the pathological stage and progression-free survival. Material and Methods: Between February 1992 and August 2002, 239 radical cystectomies were carried out as a result of TCC of the bladder. In a total of 189 patients (79%), cystectomy was carried out due to muscle-infiltrated TCC with no evidence of distant metastases (≥T2, M0). The time between the diagnosis of muscle invasion and cystectomy was determined for all of these patients, who were then divided into two groups on the basis of a 3-month cut-off period. Univariate and multivariate analyses were used to determine the effect of the time period on clinical factors and progression-free survival. Results: The average age of the patients was 63 (range 35-80) years. A median follow-up of 40 months showed a progression-free survival rate of 49% after 5 years. The average time between the diagnosis of muscle invasion and cystectomy was 1.8 (0.3-12.1) months. For a time window of >3 months, 30/42 patients (72%) showed signs of extravesical tumor growth and/or tumor-positive lymph nodes, compared to 89/147 patients (60%) ( p = 0.198) for a time window of ≤3 months. In terms of the distribution of tumor stages according to the time groups, there were significantly more pT4 stage tumors in patients with delayed cystectomy ( p = 0.009). Patients with a time interval of ≤3 months between diagnosis of muscle invasion and cystectomy had a significantly better progression-free survival rate (55%) than those with a longer time window (34%) ( p = 0.04). In contrast to lymph node status, clinical stage, pathological tumor stage and differentiation level, the prognostic relevance of the time window fell just short of the significance level in Cox's multivariate regression analysis ( p = 0.057). Lymph node status ( p < 0.001) and pathological tumor stage ( p = 0.05) were the only independent prognostic parameters which could be used to predict progression-free survival. Conclusion: Patients with a time window of >3 months between diagnosis of muscle invasion and radical cystectomy were associated with an advanced pathological stage and a poorer progression-free survival. These results underline the need for early cystectomy within the 3-month period between diagnosis of muscle invasion and cystectomy. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Scandinavian Journal of Urology & Nephrology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      00365599
    • Accession Number:
      13078146
  • Citations
    • ABNT:
      BUTLER, R. J. et al. An exploration of outcome criteria in nocturnal enuresis treatment. Scandinavian Journal of Urology & Nephrology, [s. l.], v. 38, n. 3, p. 196, 2004. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=13078146. Acesso em: 30 set. 2020.
    • AMA:
      Butler RJ, Robinson JC, Holland P, Doherty-Williams D. An exploration of outcome criteria in nocturnal enuresis treatment. Scandinavian Journal of Urology & Nephrology. 2004;38(3):196. Accessed September 30, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=13078146
    • APA:
      Butler, R. J., Robinson, J. C., Holland, P., & Doherty-Williams, D. (2004). An exploration of outcome criteria in nocturnal enuresis treatment. Scandinavian Journal of Urology & Nephrology, 38(3), 196.
    • Chicago/Turabian: Author-Date:
      Butler, Richard J., Joanne C. Robinson, Philip Holland, and Dianne Doherty-Williams. 2004. “An Exploration of Outcome Criteria in Nocturnal Enuresis Treatment.” Scandinavian Journal of Urology & Nephrology 38 (3): 196. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=13078146.
    • Harvard:
      Butler, R. J. et al. (2004) ‘An exploration of outcome criteria in nocturnal enuresis treatment’, Scandinavian Journal of Urology & Nephrology, 38(3), p. 196. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=13078146 (Accessed: 30 September 2020).
    • Harvard: Australian:
      Butler, RJ, Robinson, JC, Holland, P & Doherty-Williams, D 2004, ‘An exploration of outcome criteria in nocturnal enuresis treatment’, Scandinavian Journal of Urology & Nephrology, vol. 38, no. 3, p. 196, viewed 30 September 2020, .
    • MLA:
      Butler, Richard J., et al. “An Exploration of Outcome Criteria in Nocturnal Enuresis Treatment.” Scandinavian Journal of Urology & Nephrology, vol. 38, no. 3, June 2004, p. 196. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=13078146.
    • Chicago/Turabian: Humanities:
      Butler, Richard J., Joanne C. Robinson, Philip Holland, and Dianne Doherty-Williams. “An Exploration of Outcome Criteria in Nocturnal Enuresis Treatment.” Scandinavian Journal of Urology & Nephrology 38, no. 3 (June 2004): 196. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=13078146.
    • Vancouver/ICMJE:
      Butler RJ, Robinson JC, Holland P, Doherty-Williams D. An exploration of outcome criteria in nocturnal enuresis treatment. Scandinavian Journal of Urology & Nephrology [Internet]. 2004 Jun [cited 2020 Sep 30];38(3):196. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=13078146