Hyaluronan: More than just a wrinkle filler. (English)

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Author(s): Maytin, Edward V.
  • Language:
  • Source:
    Glycobiology; Jun2016, Vol. 26 Issue 6, p553-559, 7p
  • Additional Information
    • Publication Year:
    • Author-Supplied Keywords:
      wound healing
    • Abstract:
      Dermatology is a field that strives not only to alleviate skin disease (therapeutics) but also to improve the perception of wellness (cosmetics). Thus, in this special issue of Glycobiology, it seems appropriate to discuss the biology of a glycosaminoglycan, called hyaluronic acid (hyaluronan, or HA), that has become the most popular agent today for intradermal injections to improve wrinkles and other cosmetic defects. HA is a simple linear polymer in which a simple disaccharide is repeated thousands of time, thereby creating a huge hydrophilic molecule that confers a large volume of hydration and contributes to the turgor and flexibility of healthy skin. Beyond cosmetic considerations, however, HA also has important biological and physiological functions that were largely under-appreciated until recently. New research has confirmed that HA is dynamically produced by most skin cells, not only fibroblasts (the cells that make most of the skin's extracellular matrix) but also by keratinocytes in the outer protective layer (epidermis). For both fibroblasts and keratinocytes, HA plays a regulatory role in controlling cell physiology through interaction of extracellular HAwith a major cellsurface receptor, CD44. This interaction mediates intracellular signaling both directly and indirectly, through CD44 interactions with the cytoskeleton and with EGF and TGFβ receptors. Furthermore, degradation of HA by specific hyaluronidase enzymes produces HA fragments that can help to regulate inflammatory processes. In this review, current knowledge about the role of HA in skin inflammation and wound healing are reviewed and possible future applications of such knowledge discussed. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Glycobiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
    • Accession Number:
  • Citations
    • ABNT:
      MAYTIN, E. V. Hyaluronan: More than just a wrinkle filler. (English). Glycobiology, [s. l.], v. 26, n. 6, p. 553, 2016. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=114923101. Acesso em: 7 ago. 2020.
    • AMA:
      Maytin EV. Hyaluronan: More than just a wrinkle filler. (English). Glycobiology. 2016;26(6):553. Accessed August 7, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=114923101
    • APA:
      Maytin, E. V. (2016). Hyaluronan: More than just a wrinkle filler. (English). Glycobiology, 26(6), 553.
    • Chicago/Turabian: Author-Date:
      Maytin, Edward V. 2016. “Hyaluronan: More than Just a Wrinkle Filler. (English).” Glycobiology 26 (6): 553. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=114923101.
    • Harvard:
      Maytin, E. V. (2016) ‘Hyaluronan: More than just a wrinkle filler. (English)’, Glycobiology, 26(6), p. 553. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=114923101 (Accessed: 7 August 2020).
    • Harvard: Australian:
      Maytin, EV 2016, ‘Hyaluronan: More than just a wrinkle filler. (English)’, Glycobiology, vol. 26, no. 6, p. 553, viewed 7 August 2020, .
    • MLA:
      Maytin, Edward V. “Hyaluronan: More than Just a Wrinkle Filler. (English).” Glycobiology, vol. 26, no. 6, June 2016, p. 553. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=114923101.
    • Chicago/Turabian: Humanities:
      Maytin, Edward V. “Hyaluronan: More than Just a Wrinkle Filler. (English).” Glycobiology 26, no. 6 (June 2016): 553. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=114923101.
    • Vancouver/ICMJE:
      Maytin EV. Hyaluronan: More than just a wrinkle filler. (English). Glycobiology [Internet]. 2016 Jun [cited 2020 Aug 7];26(6):553. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=114923101