Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years.

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  • Additional Information
    • Publication Year:
      2015
    • Subject Terms:
    • Author-Supplied Keywords:
      cohort studies
      Dutch Hunger Winter
      famine
      fetal origins
      prenatal exposure delayed effects
      undernutrition
    • Abstract:
      Nutritional conditions in early life may affect adult health, but prior studies of mortality have been limited to small samples. We evaluated the relationship between pre-/perinatal famine exposure during the Dutch Hunger Winter of 1944–1945 and mortality through age 63 years among 41,096 men born in 1944–1947 and examined at age 18 years for universal military service in the Netherlands. Of these men, 22,952 had been born around the time of the Dutch famine in 6 affected cities; the remainder served as unexposed controls. Cox proportional hazards models were used to estimate hazard ratios for death from cancer, heart disease, other natural causes, and external causes. After 1,853,023 person-years of follow-up, we recorded 1,938 deaths from cancer, 1,040 from heart disease, 1,418 from other natural causes, and 523 from external causes. We found no increase in mortality from cancer or cardiovascular disease after prenatal famine exposure. However, there were increases in mortality from other natural causes (hazard ratio = 1.24, 95% confidence interval: 1.03, 1.49) and external causes (hazard ratio = 1.46, 95% confidence interval: 1.09, 1.97) after famine exposure in the first trimester of gestation. Further follow-up of the cohort is needed to provide more accurate risk estimates of mortality from specific causes of death after nutritional disturbances during gestation and very early life. [ABSTRACT FROM PUBLISHER]
    • Abstract:
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    • ISSN:
      00029262
    • Accession Number:
      101033176
  • Citations
    • ABNT:
      EKAMPER, P. et al. Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years. American Journal of Epidemiology, [s. l.], v. 181, n. 4, p. 271, 2015. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=101033176. Acesso em: 5 jun. 2020.
    • AMA:
      Ekamper P, van Poppel F, Stein AD, Bijwaard GE, Lumey LH. Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years. American Journal of Epidemiology. 2015;181(4):271. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=101033176. Accessed June 5, 2020.
    • APA:
      Ekamper, P., van Poppel, F., Stein, A. D., Bijwaard, G. E., & Lumey, L. H. (2015). Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years. American Journal of Epidemiology, 181(4), 271.
    • Chicago/Turabian: Author-Date:
      Ekamper, Peter, Frans van Poppel, Aryeh D. Stein, Govert E. Bijwaard, and L. H. Lumey. 2015. “Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years.” American Journal of Epidemiology 181 (4): 271. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=101033176.
    • Harvard:
      Ekamper, P. et al. (2015) ‘Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years’, American Journal of Epidemiology, 181(4), p. 271. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=101033176 (Accessed: 5 June 2020).
    • Harvard: Australian:
      Ekamper, P, van Poppel, F, Stein, AD, Bijwaard, GE & Lumey, LH 2015, ‘Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years’, American Journal of Epidemiology, vol. 181, no. 4, p. 271, viewed 5 June 2020, .
    • MLA:
      Ekamper, Peter, et al. “Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years.” American Journal of Epidemiology, vol. 181, no. 4, Feb. 2015, p. 271. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=101033176.
    • Chicago/Turabian: Humanities:
      Ekamper, Peter, Frans van Poppel, Aryeh D. Stein, Govert E. Bijwaard, and L. H. Lumey. “Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years.” American Journal of Epidemiology 181, no. 4 (February 15, 2015): 271. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=101033176.
    • Vancouver/ICMJE:
      Ekamper P, van Poppel F, Stein AD, Bijwaard GE, Lumey LH. Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years. American Journal of Epidemiology [Internet]. 2015 Feb 15 [cited 2020 Jun 5];181(4):271. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=101033176