Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco-Colombia.

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  • Additional Information
    • Alternate Title:
      Relacion entre genotipos del grupo sanguíneo Duffy e infección malárica en diferentes etnias de Choco-Colombia.
    • Subject Terms:
    • Author-Supplied Keywords:
      Colombia
      Duffy Blood-Group System
      ethnic groups
      Genotypes
      malaria
      PCR-RFLP
      Plasmodium falciparum
      Plasmodium vivax
      Genotipos
      grupo etnico
      Plasmodium falciparum
      Plasmodium vivax
      Sistema del Grupo Sanguineo Duffy
      Language of Keywords: English; Spanish
    • Abstract:
      Background: The negative homozygous condition for the Duffy blood group (Fy-/Fy-) confers natural resistance to Plasmodium vivax infection. In this direction, studies carried out in Colombia are scarce Objective: To describe the relationship between Duffy genotypes in three ethnic communities in La Italia (Choco) and malaria infection.w Methodology: a descriptive, cross-sectional study in symptomatic and asymptomatic malaria subjects. Sample size : Afro American, 73; Amerindian (Embera), 74 and Mestizo, 171. Presence of Plasmodium infection was assessed by thick smear and the status of the Duffy gene by PCR and RFLP in order to identify the substitutions T-46C y A131G which origin the genotypes T/T, T/C , C/C y G/G, G/A, A/A. Results: Infection by Plasmodium was detected in 17% with 62% due to P. falciparum and 27% to P. vivax. Duffy genotypes were significantly associated to ethnicity (p=0,003). Individuals with the C/C, A/A diplotype were exclusively infected by P. falciparum, whereas other diplotypes were infected with either species. In the Amerindian and Mestizo populations, the frequency of the T-46 allele was 0,90-1,00, among Afrocolombians this was 0,50, equal to the C allele and with absence of heterozygous At locus 131, the highest frequency of the G allele was 0,30 in Amerindians and the A allele was 0,69 in Afrocolombians. Conclusions: In the Amerindian and mestizo populations studied, a predominance of the allele T-46 (FY+) was observed, but P. vivax was not the most common. Infection by P. vivax was out ruled in all FY- individuals. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Introducción: La condicion homocigotica negativa del grupo sanguineo Duffy ((Fy-/Fy-) confiere resistencia natural a Plasmodium vivax. En este sentido, los estudios realizados en Colombia son escasos. Objetivo: describir la relacion entre los genotipos Duffy en tres comunidades etnicas de La Italia (Choco), y la malaria. Metodologia: estudio descriptivo, transversal con individuos sintomaticos o asintomaticos de malaria. Tamano muestral por etnia: afrocolombiana 73; amerindia 74, mestiza171. La infeccion plasmodial se estudio por gota gruesa y el estado del gen Duffy por PCR y RFLP con el fin de identificar los cambios T-46C y A131G que originan los genotipos T/T, T/C , C/C y G/G, G/A, A/A. Resultados: se encontro infeccion plasmodial en 17% con 62% por P. falciparum y 27% por P. vivax. Se hallo relacion entre genotipos Duffy y etnia (p=0,003). Los individuos con diplotipos C/C,A/A se infectaron exclusivamente con P. falciparum, mientras que otros diplotipos por las dos especies. En amerindios y mestizos la frecuencia del alelo T-46 fue 0,90-1,00, en afrocolombianos fue 0,50, al igual que el alelo C, con ausencia de heterocigotos. En el locus 131 la maxima frecuencia del alelo G fue 0,30 en amerindios y la maxima del alelo A fue 0,69 en afrocolombianos. Conclusiones: En las poblaciones amerindia y mestiza estudiadas predomina el alelo T-46 (FY+), pero no predomina en ellas la infeccion por P. vivax. Ningun individuo FY- tuvo infeccion por P. vivax. [ABSTRACT FROM AUTHOR]
    • :
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    • Author Affiliations:
      1Universidad de Antioquia, Medellin Colombia
    • ISSN:
      0120-8322
    • Accession Number:
      82559067
  • Citations
    • ABNT:
      GONZALEZ, L. et al. Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco-Colombia. Colombia Medica, [s. l.], v. 43, n. 3, p. 189–195, 2012. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asr&AN=82559067. Acesso em: 26 nov. 2020.
    • AMA:
      Gonzalez L, Vega J, Ramirez JL, Bedoya G, Carmona-Fonseca J, Maestre A. Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco-Colombia. Colombia Medica. 2012;43(3):189-195. Accessed November 26, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asr&AN=82559067
    • APA:
      Gonzalez, L., Vega, J., Ramirez, J. L., Bedoya, G., Carmona-Fonseca, J., & Maestre, A. (2012). Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco-Colombia. Colombia Medica, 43(3), 189–195.
    • Chicago/Turabian: Author-Date:
      Gonzalez, Lina, Jorge Vega, Jose L. Ramirez, Gabriel Bedoya, Jaime Carmona-Fonseca, and Amanda Maestre. 2012. “Relationship between Duffy Blood Groups Genotypes and Malaria Infection in Different Ethnic Groups of Choco-Colombia.” Colombia Medica 43 (3): 189–95. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asr&AN=82559067.
    • Harvard:
      Gonzalez, L. et al. (2012) ‘Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco-Colombia’, Colombia Medica, 43(3), pp. 189–195. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asr&AN=82559067 (Accessed: 26 November 2020).
    • Harvard: Australian:
      Gonzalez, L, Vega, J, Ramirez, JL, Bedoya, G, Carmona-Fonseca, J & Maestre, A 2012, ‘Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco-Colombia’, Colombia Medica, vol. 43, no. 3, pp. 189–195, viewed 26 November 2020, .
    • MLA:
      Gonzalez, Lina, et al. “Relationship between Duffy Blood Groups Genotypes and Malaria Infection in Different Ethnic Groups of Choco-Colombia.” Colombia Medica, vol. 43, no. 3, July 2012, pp. 189–195. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asr&AN=82559067.
    • Chicago/Turabian: Humanities:
      Gonzalez, Lina, Jorge Vega, Jose L. Ramirez, Gabriel Bedoya, Jaime Carmona-Fonseca, and Amanda Maestre. “Relationship between Duffy Blood Groups Genotypes and Malaria Infection in Different Ethnic Groups of Choco-Colombia.” Colombia Medica 43, no. 3 (July 2012): 189–95. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asr&AN=82559067.
    • Vancouver/ICMJE:
      Gonzalez L, Vega J, Ramirez JL, Bedoya G, Carmona-Fonseca J, Maestre A. Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco-Colombia. Colombia Medica [Internet]. 2012 Jul [cited 2020 Nov 26];43(3):189–95. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asr&AN=82559067